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Gene: THRAP3 |
Gene summary for THRAP3 |
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Gene information | Species | Human | Gene symbol | THRAP3 | Gene ID | 9967 |
Gene name | thyroid hormone receptor associated protein 3 | |
Gene Alias | BCLAF2 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q9Y2W1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9967 | THRAP3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.63e-08 | 5.73e-01 | -0.1954 |
9967 | THRAP3 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.63e-03 | 7.64e-01 | -0.2602 |
9967 | THRAP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.00e-02 | 5.13e-01 | -0.059 |
9967 | THRAP3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.56e-05 | 1.12e+00 | 0.3487 |
9967 | THRAP3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.84e-03 | 5.39e-01 | 0.281 |
9967 | THRAP3 | A002-C-010 | Human | Colorectum | FAP | 1.92e-03 | -1.85e-01 | 0.242 |
9967 | THRAP3 | A015-C-203 | Human | Colorectum | FAP | 1.45e-23 | -3.12e-01 | -0.1294 |
9967 | THRAP3 | A015-C-204 | Human | Colorectum | FAP | 5.84e-04 | -1.95e-01 | -0.0228 |
9967 | THRAP3 | A014-C-040 | Human | Colorectum | FAP | 6.58e-04 | -3.19e-01 | -0.1184 |
9967 | THRAP3 | A002-C-201 | Human | Colorectum | FAP | 9.63e-11 | -3.15e-01 | 0.0324 |
9967 | THRAP3 | A002-C-203 | Human | Colorectum | FAP | 5.96e-07 | -1.87e-01 | 0.2786 |
9967 | THRAP3 | A001-C-119 | Human | Colorectum | FAP | 2.12e-03 | -4.78e-02 | -0.1557 |
9967 | THRAP3 | A001-C-108 | Human | Colorectum | FAP | 8.24e-14 | -1.66e-01 | -0.0272 |
9967 | THRAP3 | A002-C-205 | Human | Colorectum | FAP | 5.34e-18 | -2.18e-01 | -0.1236 |
9967 | THRAP3 | A001-C-104 | Human | Colorectum | FAP | 9.88e-03 | -8.36e-02 | 0.0184 |
9967 | THRAP3 | A015-C-005 | Human | Colorectum | FAP | 1.39e-02 | -2.04e-01 | -0.0336 |
9967 | THRAP3 | A015-C-006 | Human | Colorectum | FAP | 1.40e-12 | -7.38e-03 | -0.0994 |
9967 | THRAP3 | A015-C-106 | Human | Colorectum | FAP | 4.26e-11 | -1.84e-01 | -0.0511 |
9967 | THRAP3 | A002-C-114 | Human | Colorectum | FAP | 4.02e-14 | -2.71e-01 | -0.1561 |
9967 | THRAP3 | A015-C-104 | Human | Colorectum | FAP | 3.21e-22 | -1.45e-01 | -0.1899 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0048024 | Colorectum | AD | regulation of mRNA splicing, via spliceosome | 50/3918 | 101/18723 | 1.62e-10 | 1.56e-08 | 50 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THRAP3 | SNV | Missense_Mutation | c.428N>G | p.Ser143Cys | p.S143C | Q9Y2W1 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-DM-A1D0-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
THRAP3 | SNV | Missense_Mutation | rs756574594 | c.2767N>A | p.Ala923Thr | p.A923T | Q9Y2W1 | protein_coding | tolerated(0.97) | probably_damaging(0.935) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THRAP3 | SNV | Missense_Mutation | novel | c.83C>T | p.Ser28Leu | p.S28L | Q9Y2W1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.995) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
THRAP3 | SNV | Missense_Mutation | novel | c.1065N>T | p.Glu355Asp | p.E355D | Q9Y2W1 | protein_coding | deleterious(0.01) | possibly_damaging(0.763) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
THRAP3 | SNV | Missense_Mutation | novel | c.1786G>T | p.Asp596Tyr | p.D596Y | Q9Y2W1 | protein_coding | deleterious(0.01) | probably_damaging(0.935) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
THRAP3 | insertion | Frame_Shift_Ins | novel | c.2263_2264insA | p.Thr757AsnfsTer6 | p.T757Nfs*6 | Q9Y2W1 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
THRAP3 | SNV | Missense_Mutation | rs148045717 | c.68N>A | p.Arg23His | p.R23H | Q9Y2W1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THRAP3 | SNV | Missense_Mutation | novel | c.449C>A | p.Ser150Tyr | p.S150Y | Q9Y2W1 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THRAP3 | SNV | Missense_Mutation | c.2089N>G | p.Lys697Glu | p.K697E | Q9Y2W1 | protein_coding | tolerated(0.26) | probably_damaging(0.993) | TCGA-AJ-A23M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | unknown | PD | |
THRAP3 | SNV | Missense_Mutation | novel | c.50G>A | p.Arg17Lys | p.R17K | Q9Y2W1 | protein_coding | possibly_damaging(0.555) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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