![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TGFBR3 |
Gene summary for TGFBR3 |
![]() |
Gene information | Species | Human | Gene symbol | TGFBR3 | Gene ID | 7049 |
Gene name | transforming growth factor beta receptor 3 | |
Gene Alias | BGCAN | |
Cytomap | 1p22.1 | |
Gene Type | protein-coding | GO ID | GO:0001568 | UniProtAcc | A0A0A8KWK3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7049 | TGFBR3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.48e-11 | 4.28e-01 | 0.294 |
7049 | TGFBR3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.47e-06 | 1.40e+00 | 0.3487 |
7049 | TGFBR3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.61e-05 | 5.21e-01 | 0.281 |
7049 | TGFBR3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.17e-20 | 8.14e-01 | 0.3859 |
7049 | TGFBR3 | A002-C-010 | Human | Colorectum | FAP | 2.94e-07 | 3.51e-01 | 0.242 |
7049 | TGFBR3 | A002-C-021 | Human | Colorectum | FAP | 5.95e-12 | 4.77e-01 | 0.1171 |
7049 | TGFBR3 | CRC-3-11773 | Human | Colorectum | CRC | 8.42e-07 | 5.28e-01 | 0.2564 |
7049 | TGFBR3 | S41 | Human | Liver | Cirrhotic | 1.36e-02 | 6.64e-01 | -0.0343 |
7049 | TGFBR3 | HCC1_Meng | Human | Liver | HCC | 1.19e-02 | -1.57e-01 | 0.0246 |
7049 | TGFBR3 | HCC2_Meng | Human | Liver | HCC | 2.97e-07 | -5.08e-02 | 0.0107 |
7049 | TGFBR3 | S014 | Human | Liver | HCC | 9.09e-18 | 9.80e-01 | 0.2254 |
7049 | TGFBR3 | S015 | Human | Liver | HCC | 3.01e-14 | 1.11e+00 | 0.2375 |
7049 | TGFBR3 | S016 | Human | Liver | HCC | 9.83e-24 | 1.12e+00 | 0.2243 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00510982 | Colorectum | MSS | regulation of binding | 113/3467 | 363/18723 | 3.55e-09 | 2.41e-07 | 113 |
GO:00341012 | Colorectum | MSS | erythrocyte homeostasis | 49/3467 | 129/18723 | 1.58e-07 | 7.19e-06 | 49 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:00022622 | Colorectum | MSS | myeloid cell homeostasis | 55/3467 | 157/18723 | 6.35e-07 | 2.34e-05 | 55 |
GO:00488722 | Colorectum | MSS | homeostasis of number of cells | 82/3467 | 272/18723 | 2.02e-06 | 6.28e-05 | 82 |
GO:00302182 | Colorectum | MSS | erythrocyte differentiation | 44/3467 | 120/18723 | 2.03e-06 | 6.28e-05 | 44 |
GO:00610082 | Colorectum | MSS | hepaticobiliary system development | 51/3467 | 150/18723 | 4.33e-06 | 1.23e-04 | 51 |
GO:00018892 | Colorectum | MSS | liver development | 50/3467 | 147/18723 | 5.28e-06 | 1.44e-04 | 50 |
GO:00433932 | Colorectum | MSS | regulation of protein binding | 62/3467 | 196/18723 | 6.44e-06 | 1.69e-04 | 62 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
GO:00434342 | Colorectum | MSS | response to peptide hormone | 104/3467 | 414/18723 | 4.58e-04 | 5.43e-03 | 104 |
GO:00506731 | Colorectum | MSS | epithelial cell proliferation | 108/3467 | 437/18723 | 6.76e-04 | 7.30e-03 | 108 |
GO:00486381 | Colorectum | MSS | regulation of developmental growth | 84/3467 | 330/18723 | 1.01e-03 | 1.01e-02 | 84 |
GO:00486391 | Colorectum | MSS | positive regulation of developmental growth | 49/3467 | 174/18723 | 1.17e-03 | 1.13e-02 | 49 |
GO:00459272 | Colorectum | MSS | positive regulation of growth | 68/3467 | 259/18723 | 1.24e-03 | 1.19e-02 | 68 |
GO:00973051 | Colorectum | MSS | response to alcohol | 66/3467 | 253/18723 | 1.73e-03 | 1.54e-02 | 66 |
GO:00311001 | Colorectum | MSS | animal organ regeneration | 25/3467 | 76/18723 | 1.91e-03 | 1.66e-02 | 25 |
GO:00704822 | Colorectum | MSS | response to oxygen levels | 85/3467 | 347/18723 | 3.08e-03 | 2.34e-02 | 85 |
GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TGFBR3 | SNV | Missense_Mutation | novel | c.1049G>T | p.Arg350Ile | p.R350I | Q03167 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TGFBR3 | deletion | Frame_Shift_Del | c.830delN | p.Lys277SerfsTer6 | p.K277Sfs*6 | Q03167 | protein_coding | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TGFBR3 | SNV | Missense_Mutation | rs373781090 | c.2240N>T | p.Thr747Met | p.T747M | Q03167 | protein_coding | deleterious(0.03) | probably_damaging(0.944) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TGFBR3 | SNV | Missense_Mutation | rs148843052 | c.494N>A | p.Arg165Gln | p.R165Q | Q03167 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TGFBR3 | SNV | Missense_Mutation | novel | c.1627C>A | p.Leu543Met | p.L543M | Q03167 | protein_coding | tolerated(0.32) | possibly_damaging(0.462) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TGFBR3 | SNV | Missense_Mutation | novel | c.1027A>G | p.Thr343Ala | p.T343A | Q03167 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TGFBR3 | SNV | Missense_Mutation | novel | c.1244N>G | p.Glu415Gly | p.E415G | Q03167 | protein_coding | tolerated(0.33) | benign(0.154) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TGFBR3 | SNV | Missense_Mutation | novel | c.680N>A | p.Pro227His | p.P227H | Q03167 | protein_coding | tolerated(0.25) | benign(0.014) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TGFBR3 | SNV | Missense_Mutation | c.635A>G | p.Tyr212Cys | p.Y212C | Q03167 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TGFBR3 | SNV | Missense_Mutation | c.1691G>A | p.Arg564Gln | p.R564Q | Q03167 | protein_coding | tolerated(0.35) | possibly_damaging(0.655) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CYTOKINES | 16634800 | ||
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | DEXAMETHASONE | DEXAMETHASONE | 8143777 | |
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | RANTES | 14637022 | ||
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | BFGF | 1556106 | ||
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | antidepressants | 23092981 | ||
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | GM-CSF | REGRAMOSTIM | 12471017 | |
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | TG-C | |||
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | TGF-BETA 2 | 1744125 | ||
7049 | TGFBR3 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | RETINOIC ACID | 8143777 |
Page: 1 |