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Gene: TFPI |
Gene summary for TFPI |
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Gene information | Species | Human | Gene symbol | TFPI | Gene ID | 7035 |
Gene name | tissue factor pathway inhibitor | |
Gene Alias | EPI | |
Cytomap | 2q32.1 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | P10646 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7035 | TFPI | AEH-subject2 | Human | Endometrium | AEH | 2.29e-05 | -9.00e-02 | -0.2525 |
7035 | TFPI | AEH-subject3 | Human | Endometrium | AEH | 1.70e-04 | -1.45e-01 | -0.2576 |
7035 | TFPI | AEH-subject4 | Human | Endometrium | AEH | 3.62e-02 | -3.74e-02 | -0.2657 |
7035 | TFPI | EEC-subject1 | Human | Endometrium | EEC | 4.70e-07 | -1.47e-01 | -0.2682 |
7035 | TFPI | EEC-subject2 | Human | Endometrium | EEC | 3.89e-10 | -1.56e-01 | -0.2607 |
7035 | TFPI | EEC-subject3 | Human | Endometrium | EEC | 5.38e-05 | -3.19e-02 | -0.2525 |
7035 | TFPI | EEC-subject5 | Human | Endometrium | EEC | 7.78e-06 | -1.41e-01 | -0.249 |
7035 | TFPI | GSM5276934 | Human | Endometrium | EEC | 1.00e-18 | 5.41e-01 | -0.0913 |
7035 | TFPI | GSM5276935 | Human | Endometrium | EEC | 4.30e-04 | -1.30e-01 | -0.123 |
7035 | TFPI | GSM5276937 | Human | Endometrium | EEC | 2.01e-19 | 5.60e-01 | -0.0897 |
7035 | TFPI | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.41e-05 | -1.42e-01 | -0.1869 |
7035 | TFPI | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 9.87e-05 | -1.56e-01 | -0.1875 |
7035 | TFPI | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.46e-06 | -1.56e-01 | -0.1883 |
7035 | TFPI | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 8.71e-07 | -1.56e-01 | -0.1934 |
7035 | TFPI | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.89e-07 | -1.56e-01 | -0.1917 |
7035 | TFPI | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.91e-09 | -1.12e-01 | -0.1916 |
7035 | TFPI | LZE2T | Human | Esophagus | ESCC | 4.49e-03 | 3.59e-01 | 0.082 |
7035 | TFPI | LZE8T | Human | Esophagus | ESCC | 3.38e-17 | 9.25e-01 | 0.067 |
7035 | TFPI | P4T-E | Human | Esophagus | ESCC | 3.84e-21 | 9.49e-01 | 0.1323 |
7035 | TFPI | P8T-E | Human | Esophagus | ESCC | 1.72e-16 | 5.06e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206016 | Endometrium | AEH | wound healing | 91/2100 | 422/18723 | 4.85e-10 | 4.61e-08 | 91 |
GO:004854516 | Endometrium | AEH | response to steroid hormone | 76/2100 | 339/18723 | 2.15e-09 | 1.77e-07 | 76 |
GO:005254716 | Endometrium | AEH | regulation of peptidase activity | 85/2100 | 461/18723 | 2.47e-06 | 7.11e-05 | 85 |
GO:00323557 | Endometrium | AEH | response to estradiol | 34/2100 | 141/18723 | 1.13e-05 | 2.53e-04 | 34 |
GO:007138310 | Endometrium | AEH | cellular response to steroid hormone stimulus | 44/2100 | 204/18723 | 1.41e-05 | 3.01e-04 | 44 |
GO:005254816 | Endometrium | AEH | regulation of endopeptidase activity | 76/2100 | 432/18723 | 4.42e-05 | 7.43e-04 | 76 |
GO:000223710 | Endometrium | AEH | response to molecule of bacterial origin | 65/2100 | 363/18723 | 9.00e-05 | 1.30e-03 | 65 |
GO:003249610 | Endometrium | AEH | response to lipopolysaccharide | 62/2100 | 343/18723 | 9.82e-05 | 1.41e-03 | 62 |
GO:004586116 | Endometrium | AEH | negative regulation of proteolysis | 63/2100 | 351/18723 | 1.07e-04 | 1.53e-03 | 63 |
GO:00075967 | Endometrium | AEH | blood coagulation | 43/2100 | 217/18723 | 1.42e-04 | 1.89e-03 | 43 |
GO:00075997 | Endometrium | AEH | hemostasis | 43/2100 | 222/18723 | 2.39e-04 | 2.86e-03 | 43 |
GO:00508177 | Endometrium | AEH | coagulation | 43/2100 | 222/18723 | 2.39e-04 | 2.86e-03 | 43 |
GO:005134610 | Endometrium | AEH | negative regulation of hydrolase activity | 65/2100 | 379/18723 | 3.18e-04 | 3.57e-03 | 65 |
GO:005087815 | Endometrium | AEH | regulation of body fluid levels | 64/2100 | 379/18723 | 5.40e-04 | 5.44e-03 | 64 |
GO:190303410 | Endometrium | AEH | regulation of response to wounding | 32/2100 | 167/18723 | 1.69e-03 | 1.36e-02 | 32 |
GO:00610419 | Endometrium | AEH | regulation of wound healing | 27/2100 | 134/18723 | 1.77e-03 | 1.41e-02 | 27 |
GO:00712229 | Endometrium | AEH | cellular response to lipopolysaccharide | 37/2100 | 209/18723 | 3.30e-03 | 2.31e-02 | 37 |
GO:00712169 | Endometrium | AEH | cellular response to biotic stimulus | 42/2100 | 246/18723 | 3.65e-03 | 2.50e-02 | 42 |
GO:001046610 | Endometrium | AEH | negative regulation of peptidase activity | 43/2100 | 262/18723 | 6.78e-03 | 3.95e-02 | 43 |
GO:00712199 | Endometrium | AEH | cellular response to molecule of bacterial origin | 37/2100 | 221/18723 | 8.34e-03 | 4.56e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04610 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046101 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFPI | SNV | Missense_Mutation | novel | c.508N>A | p.Glu170Lys | p.E170K | P10646 | protein_coding | deleterious(0) | possibly_damaging(0.85) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFPI | SNV | Missense_Mutation | novel | c.404G>A | p.Arg135Gln | p.R135Q | P10646 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TFPI | deletion | Frame_Shift_Del | c.307delN | p.Met103CysfsTer11 | p.M103Cfs*11 | P10646 | protein_coding | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TFPI | deletion | Frame_Shift_Del | novel | c.807delA | p.Gly270ValfsTer11 | p.G270Vfs*11 | P10646 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TFPI | SNV | Missense_Mutation | c.401N>T | p.Cys134Phe | p.C134F | P10646 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
TFPI | SNV | Missense_Mutation | c.596N>T | p.Thr199Ile | p.T199I | P10646 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-55-8097-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TFPI | SNV | Missense_Mutation | c.157N>C | p.Phe53Leu | p.F53L | P10646 | protein_coding | tolerated(0.15) | possibly_damaging(0.577) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TFPI | SNV | Missense_Mutation | c.372C>A | p.Phe124Leu | p.F124L | P10646 | protein_coding | tolerated(0.09) | benign(0.038) | TCGA-43-A474-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
TFPI | deletion | Frame_Shift_Del | c.307delA | p.Met103CysfsTer11 | p.M103Cfs*11 | P10646 | protein_coding | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TFPI | SNV | Missense_Mutation | novel | c.742N>G | p.Ser248Gly | p.S248G | P10646 | protein_coding | tolerated(0.22) | possibly_damaging(0.829) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | PI-88 | MUPARFOSTAT | 11292191 | |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | CHONDROITIN SULFATE | 10959709 | ||
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | AZITHROMYCIN | AZITHROMYCIN | 16113783 | |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | HEPARIN | HEPARIN | 11150580 | |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | NN-7415 | |||
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | LOVASTATIN | LOVASTATIN | 7600119 | |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | CREMOPHOR | 9352228 | ||
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | ATORVASTATIN | ATORVASTATIN | 15792677 | |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | FULVESTRANT | FULVESTRANT | 17029634 | |
7035 | TFPI | CELL SURFACE, DRUGGABLE GENOME, PROTEASE INHIBITOR | CHONDROITIN | 7974391 |
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