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Gene: TFCP2L1 |
Gene summary for TFCP2L1 |
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Gene information | Species | Human | Gene symbol | TFCP2L1 | Gene ID | 29842 |
Gene name | transcription factor CP2 like 1 | |
Gene Alias | CRTR1 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NZI6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29842 | TFCP2L1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.09e-15 | -5.47e-01 | 0.0155 |
29842 | TFCP2L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.56e-13 | 6.91e-01 | -0.1954 |
29842 | TFCP2L1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.87e-02 | 7.34e-01 | -0.2602 |
29842 | TFCP2L1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.27e-05 | 5.52e-01 | -0.1464 |
29842 | TFCP2L1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.10e-12 | -5.48e-01 | 0.294 |
29842 | TFCP2L1 | F007 | Human | Colorectum | FAP | 7.22e-09 | -6.05e-01 | 0.1176 |
29842 | TFCP2L1 | A002-C-010 | Human | Colorectum | FAP | 1.39e-14 | -5.26e-01 | 0.242 |
29842 | TFCP2L1 | A001-C-207 | Human | Colorectum | FAP | 3.30e-11 | -5.73e-01 | 0.1278 |
29842 | TFCP2L1 | A015-C-203 | Human | Colorectum | FAP | 3.53e-30 | -4.13e-01 | -0.1294 |
29842 | TFCP2L1 | A015-C-204 | Human | Colorectum | FAP | 5.27e-09 | -4.43e-01 | -0.0228 |
29842 | TFCP2L1 | A014-C-040 | Human | Colorectum | FAP | 3.93e-04 | -3.49e-01 | -0.1184 |
29842 | TFCP2L1 | A002-C-201 | Human | Colorectum | FAP | 1.24e-22 | -6.14e-01 | 0.0324 |
29842 | TFCP2L1 | A002-C-203 | Human | Colorectum | FAP | 9.96e-20 | -6.02e-01 | 0.2786 |
29842 | TFCP2L1 | A001-C-119 | Human | Colorectum | FAP | 7.86e-09 | -4.87e-01 | -0.1557 |
29842 | TFCP2L1 | A001-C-108 | Human | Colorectum | FAP | 7.30e-29 | -6.29e-01 | -0.0272 |
29842 | TFCP2L1 | A002-C-021 | Human | Colorectum | FAP | 4.12e-02 | -2.84e-01 | 0.1171 |
29842 | TFCP2L1 | A002-C-205 | Human | Colorectum | FAP | 8.98e-32 | -6.77e-01 | -0.1236 |
29842 | TFCP2L1 | A001-C-104 | Human | Colorectum | FAP | 4.48e-12 | -5.02e-01 | 0.0184 |
29842 | TFCP2L1 | A015-C-006 | Human | Colorectum | FAP | 2.31e-24 | -7.65e-01 | -0.0994 |
29842 | TFCP2L1 | A015-C-106 | Human | Colorectum | FAP | 3.38e-17 | -4.29e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00459271 | Colorectum | SER | positive regulation of growth | 56/2897 | 259/18723 | 5.10e-03 | 3.91e-02 | 56 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00020642 | Colorectum | MSS | epithelial cell development | 81/3467 | 220/18723 | 1.02e-10 | 1.06e-08 | 81 |
GO:00075681 | Colorectum | MSS | aging | 90/3467 | 339/18723 | 1.51e-04 | 2.19e-03 | 90 |
GO:00459272 | Colorectum | MSS | positive regulation of growth | 68/3467 | 259/18723 | 1.24e-03 | 1.19e-02 | 68 |
GO:00020644 | Colorectum | FAP | epithelial cell development | 62/2622 | 220/18723 | 2.74e-08 | 2.54e-06 | 62 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
GO:00459273 | Colorectum | FAP | positive regulation of growth | 66/2622 | 259/18723 | 6.11e-07 | 3.05e-05 | 66 |
GO:00075682 | Colorectum | FAP | aging | 69/2622 | 339/18723 | 7.66e-04 | 8.12e-03 | 69 |
GO:0021700 | Colorectum | FAP | developmental maturation | 57/2622 | 280/18723 | 2.08e-03 | 1.72e-02 | 57 |
GO:0007028 | Colorectum | FAP | cytoplasm organization | 5/2622 | 10/18723 | 7.32e-03 | 4.38e-02 | 5 |
GO:00020645 | Colorectum | CRC | epithelial cell development | 55/2078 | 220/18723 | 4.63e-09 | 1.16e-06 | 55 |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
GO:00459274 | Colorectum | CRC | positive regulation of growth | 51/2078 | 259/18723 | 3.23e-05 | 8.27e-04 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFCP2L1 | SNV | Missense_Mutation | novel | c.723N>T | p.Glu241Asp | p.E241D | Q9NZI6 | protein_coding | tolerated(0.13) | possibly_damaging(0.651) | TCGA-60-2695-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFCP2L1 | SNV | Missense_Mutation | c.217N>G | p.Gln73Glu | p.Q73E | Q9NZI6 | protein_coding | deleterious(0.04) | possibly_damaging(0.58) | TCGA-66-2786-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TFCP2L1 | SNV | Missense_Mutation | c.1396G>A | p.Glu466Lys | p.E466K | Q9NZI6 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-BA-6873-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
TFCP2L1 | SNV | Missense_Mutation | rs137971940 | c.812N>T | p.Pro271Leu | p.P271L | Q9NZI6 | protein_coding | tolerated(0.19) | possibly_damaging(0.631) | TCGA-CV-5440-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
TFCP2L1 | SNV | Missense_Mutation | c.134N>T | p.Pro45Leu | p.P45L | Q9NZI6 | protein_coding | tolerated(0.48) | benign(0.119) | TCGA-CV-5978-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TFCP2L1 | SNV | Missense_Mutation | novel | c.190N>C | p.Glu64Gln | p.E64Q | Q9NZI6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EJ-A6RA-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | PD |
TFCP2L1 | SNV | Missense_Mutation | rs747701705 | c.233N>A | p.Arg78Gln | p.R78Q | Q9NZI6 | protein_coding | tolerated(0.09) | possibly_damaging(0.627) | TCGA-YL-A8SH-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
TFCP2L1 | SNV | Missense_Mutation | c.673N>T | p.Arg225Trp | p.R225W | Q9NZI6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TFCP2L1 | SNV | Missense_Mutation | c.1028G>A | p.Arg343Gln | p.R343Q | Q9NZI6 | protein_coding | deleterious(0.02) | possibly_damaging(0.482) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TFCP2L1 | SNV | Missense_Mutation | novel | c.95N>G | p.Glu32Gly | p.E32G | Q9NZI6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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