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Gene: TEAD4 |
Gene summary for TEAD4 |
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Gene information | Species | Human | Gene symbol | TEAD4 | Gene ID | 7004 |
Gene name | TEA domain transcription factor 4 | |
Gene Alias | EFTR-2 | |
Cytomap | 12p13.33 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q15561 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7004 | TEAD4 | LZE24T | Human | Esophagus | ESCC | 7.33e-09 | 1.17e-01 | 0.0596 |
7004 | TEAD4 | P2T-E | Human | Esophagus | ESCC | 1.97e-11 | 2.60e-01 | 0.1177 |
7004 | TEAD4 | P4T-E | Human | Esophagus | ESCC | 2.10e-13 | 4.18e-01 | 0.1323 |
7004 | TEAD4 | P5T-E | Human | Esophagus | ESCC | 2.34e-13 | 3.08e-01 | 0.1327 |
7004 | TEAD4 | P8T-E | Human | Esophagus | ESCC | 1.18e-06 | 1.17e-01 | 0.0889 |
7004 | TEAD4 | P9T-E | Human | Esophagus | ESCC | 7.36e-09 | 2.46e-01 | 0.1131 |
7004 | TEAD4 | P10T-E | Human | Esophagus | ESCC | 3.66e-05 | 8.56e-02 | 0.116 |
7004 | TEAD4 | P11T-E | Human | Esophagus | ESCC | 1.24e-03 | 1.39e-01 | 0.1426 |
7004 | TEAD4 | P12T-E | Human | Esophagus | ESCC | 5.39e-14 | 3.53e-01 | 0.1122 |
7004 | TEAD4 | P15T-E | Human | Esophagus | ESCC | 9.99e-04 | 1.40e-01 | 0.1149 |
7004 | TEAD4 | P16T-E | Human | Esophagus | ESCC | 1.09e-04 | 9.63e-02 | 0.1153 |
7004 | TEAD4 | P17T-E | Human | Esophagus | ESCC | 4.15e-08 | 2.31e-01 | 0.1278 |
7004 | TEAD4 | P19T-E | Human | Esophagus | ESCC | 6.36e-09 | 5.30e-01 | 0.1662 |
7004 | TEAD4 | P20T-E | Human | Esophagus | ESCC | 1.68e-08 | 3.27e-01 | 0.1124 |
7004 | TEAD4 | P21T-E | Human | Esophagus | ESCC | 1.01e-29 | 4.46e-01 | 0.1617 |
7004 | TEAD4 | P22T-E | Human | Esophagus | ESCC | 1.27e-14 | 3.42e-01 | 0.1236 |
7004 | TEAD4 | P23T-E | Human | Esophagus | ESCC | 3.30e-16 | 4.46e-01 | 0.108 |
7004 | TEAD4 | P24T-E | Human | Esophagus | ESCC | 5.18e-32 | 9.02e-01 | 0.1287 |
7004 | TEAD4 | P26T-E | Human | Esophagus | ESCC | 2.71e-13 | 2.56e-01 | 0.1276 |
7004 | TEAD4 | P27T-E | Human | Esophagus | ESCC | 7.28e-09 | 2.18e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00353297 | Esophagus | ESCC | hippo signaling | 26/8552 | 40/18723 | 1.08e-02 | 3.66e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEAD4 | SNV | Missense_Mutation | novel | c.770N>G | p.Tyr257Cys | p.Y257C | protein_coding | deleterious(0.05) | probably_damaging(0.921) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TEAD4 | SNV | Missense_Mutation | novel | c.445G>A | p.Ala149Thr | p.A149T | protein_coding | tolerated(0.56) | benign(0.142) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TEAD4 | SNV | Missense_Mutation | novel | c.34G>A | p.Glu12Lys | p.E12K | protein_coding | tolerated_low_confidence(0.24) | benign(0.053) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
TEAD4 | SNV | Missense_Mutation | novel | c.1199N>T | p.Thr400Ile | p.T400I | protein_coding | deleterious(0.03) | possibly_damaging(0.684) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TEAD4 | SNV | Missense_Mutation | rs762656664 | c.787N>A | p.Glu263Lys | p.E263K | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TEAD4 | SNV | Missense_Mutation | c.455G>A | p.Arg152Gln | p.R152Q | protein_coding | tolerated(0.68) | benign(0.005) | TCGA-G3-A3CJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | ||
TEAD4 | SNV | Missense_Mutation | novel | c.277N>A | p.Arg93Ser | p.R93S | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TEAD4 | SNV | Missense_Mutation | novel | c.628C>T | p.Pro210Ser | p.P210S | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-78-7161-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
TEAD4 | SNV | Missense_Mutation | novel | c.219G>T | p.Lys73Asn | p.K73N | protein_coding | deleterious(0.01) | possibly_damaging(0.901) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TEAD4 | SNV | Missense_Mutation | novel | c.451G>T | p.Ala151Ser | p.A151S | protein_coding | tolerated(0.66) | benign(0.01) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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