![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: STYK1 |
Gene summary for STYK1 |
![]() |
Gene information | Species | Human | Gene symbol | STYK1 | Gene ID | 55359 |
Gene name | serine/threonine/tyrosine kinase 1 | |
Gene Alias | NOK | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q6J9G0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55359 | STYK1 | CCI_1 | Human | Cervix | CC | 1.50e-10 | 7.46e-01 | 0.528 |
55359 | STYK1 | CCI_2 | Human | Cervix | CC | 2.16e-02 | 3.46e-01 | 0.5249 |
55359 | STYK1 | CCI_3 | Human | Cervix | CC | 3.64e-06 | 5.62e-01 | 0.516 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STYK1 | SNV | Missense_Mutation | novel | c.167A>T | p.Gln56Leu | p.Q56L | Q6J9G0 | protein_coding | deleterious(0.03) | benign(0.026) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
STYK1 | insertion | Frame_Shift_Ins | novel | c.8_9insATCAGATATA | p.Met3IlefsTer15 | p.M3Ifs*15 | Q6J9G0 | protein_coding | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
STYK1 | SNV | Missense_Mutation | c.437T>C | p.Leu146Pro | p.L146P | Q6J9G0 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-RC-A7S9-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STYK1 | SNV | Missense_Mutation | novel | c.553A>T | p.Thr185Ser | p.T185S | Q6J9G0 | protein_coding | tolerated(0.54) | possibly_damaging(0.867) | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | c.1232N>A | p.Arg411Lys | p.R411K | Q6J9G0 | protein_coding | tolerated(0.63) | benign(0.01) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STYK1 | SNV | Missense_Mutation | c.321N>T | p.Gln107His | p.Q107H | Q6J9G0 | protein_coding | deleterious(0) | benign(0.33) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STYK1 | SNV | Missense_Mutation | c.1232G>C | p.Arg411Thr | p.R411T | Q6J9G0 | protein_coding | tolerated(0.44) | benign(0.01) | TCGA-21-1078-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
STYK1 | SNV | Missense_Mutation | novel | c.117N>G | p.Ile39Met | p.I39M | Q6J9G0 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
STYK1 | SNV | Missense_Mutation | novel | c.1258N>G | p.Ser420Gly | p.S420G | Q6J9G0 | protein_coding | deleterious(0) | benign(0.054) | TCGA-34-5241-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | c.193G>T | p.Ala65Ser | p.A65S | Q6J9G0 | protein_coding | tolerated(0.64) | benign(0.003) | TCGA-37-4135-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |