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Gene: STX3 |
Gene summary for STX3 |
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Gene information | Species | Human | Gene symbol | STX3 | Gene ID | 6809 |
Gene name | syntaxin 3 | |
Gene Alias | DIAR12 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q13277 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6809 | STX3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.44e-09 | 4.41e-01 | 0.0155 |
6809 | STX3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.16e-08 | 6.40e-01 | -0.1808 |
6809 | STX3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.00e-13 | 8.11e-01 | -0.0811 |
6809 | STX3 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.61e-08 | 5.87e-01 | -0.1088 |
6809 | STX3 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.60e-21 | 8.10e-01 | -0.1954 |
6809 | STX3 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.30e-05 | 1.01e+00 | -0.2602 |
6809 | STX3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.51e-05 | 8.92e-01 | -0.2196 |
6809 | STX3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.45e-08 | 6.73e-01 | -0.1526 |
6809 | STX3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.58e-07 | 5.01e-01 | -0.1464 |
6809 | STX3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.53e-16 | 9.19e-01 | -0.059 |
6809 | STX3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.96e-08 | 9.60e-01 | -0.1706 |
6809 | STX3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.26e-03 | 6.97e-01 | -0.2061 |
6809 | STX3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.78e-04 | 4.76e-01 | 0.096 |
6809 | STX3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.41e-03 | 6.49e-01 | 0.0131 |
6809 | STX3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.75e-07 | 9.81e-01 | 0.0171 |
6809 | STX3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.70e-06 | 5.72e-01 | 0.0338 |
6809 | STX3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.19e-17 | 6.95e-01 | 0.0674 |
6809 | STX3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.50e-10 | 7.24e-01 | 0.0588 |
6809 | STX3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.47e-24 | 8.65e-01 | 0.294 |
6809 | STX3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.21e-13 | 7.29e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:1905477 | Colorectum | AD | positive regulation of protein localization to membrane | 46/3918 | 106/18723 | 1.47e-07 | 6.64e-06 | 46 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:1903078 | Colorectum | AD | positive regulation of protein localization to plasma membrane | 28/3918 | 62/18723 | 1.57e-05 | 3.34e-04 | 28 |
GO:1904377 | Colorectum | AD | positive regulation of protein localization to cell periphery | 30/3918 | 69/18723 | 1.98e-05 | 4.05e-04 | 30 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0022406 | Colorectum | AD | membrane docking | 31/3918 | 86/18723 | 8.67e-04 | 8.45e-03 | 31 |
GO:0140056 | Colorectum | AD | organelle localization by membrane tethering | 28/3918 | 77/18723 | 1.29e-03 | 1.14e-02 | 28 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0034394 | Colorectum | AD | protein localization to cell surface | 24/3918 | 68/18723 | 4.33e-03 | 2.97e-02 | 24 |
GO:0099072 | Colorectum | AD | regulation of postsynaptic membrane neurotransmitter receptor levels | 22/3918 | 62/18723 | 5.72e-03 | 3.64e-02 | 22 |
GO:0098877 | Colorectum | AD | neurotransmitter receptor transport to plasma membrane | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041305 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0413012 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa04130 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa041301 | Liver | Cirrhotic | SNARE interactions in vesicular transport | 18/2530 | 33/8465 | 2.64e-03 | 1.10e-02 | 6.76e-03 | 18 |
hsa041302 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa041303 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa041304 | Oral cavity | OSCC | SNARE interactions in vesicular transport | 28/3704 | 33/8465 | 1.31e-06 | 7.18e-06 | 3.66e-06 | 28 |
hsa0413011 | Oral cavity | OSCC | SNARE interactions in vesicular transport | 28/3704 | 33/8465 | 1.31e-06 | 7.18e-06 | 3.66e-06 | 28 |
hsa0413021 | Oral cavity | LP | SNARE interactions in vesicular transport | 22/2418 | 33/8465 | 6.00e-06 | 4.76e-05 | 3.07e-05 | 22 |
hsa0413031 | Oral cavity | LP | SNARE interactions in vesicular transport | 22/2418 | 33/8465 | 6.00e-06 | 4.76e-05 | 3.07e-05 | 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STX3 | SNV | Missense_Mutation | c.200N>G | p.Pro67Arg | p.P67R | Q13277 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A1GM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
STX3 | SNV | Missense_Mutation | rs780429309 | c.395C>T | p.Thr132Ile | p.T132I | Q13277 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STX3 | SNV | Missense_Mutation | c.452G>A | p.Arg151Gln | p.R151Q | Q13277 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
STX3 | SNV | Missense_Mutation | rs376160845 | c.655G>A | p.Ala219Thr | p.A219T | Q13277 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STX3 | SNV | Missense_Mutation | rs747357728 | c.404N>G | p.Asn135Ser | p.N135S | Q13277 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-50-5072-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
STX3 | SNV | Missense_Mutation | c.650N>T | p.Asp217Val | p.D217V | Q13277 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-A492-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STX3 | SNV | Missense_Mutation | c.222N>C | p.Lys74Asn | p.K74N | Q13277 | protein_coding | deleterious(0.04) | benign(0.339) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STX3 | SNV | Missense_Mutation | c.854N>T | p.Ser285Phe | p.S285F | Q13277 | protein_coding | tolerated(0.18) | probably_damaging(0.986) | TCGA-91-6840-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STX3 | SNV | Missense_Mutation | novel | c.223N>C | p.Asp75His | p.D75H | Q13277 | protein_coding | deleterious(0.04) | possibly_damaging(0.811) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STX3 | SNV | Missense_Mutation | novel | c.679N>C | p.Glu227Gln | p.E227Q | Q13277 | protein_coding | deleterious(0) | possibly_damaging(0.556) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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