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Gene: STOML2 |
Gene summary for STOML2 |
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Gene information | Species | Human | Gene symbol | STOML2 | Gene ID | 30968 |
Gene name | stomatin like 2 | |
Gene Alias | HSPC108 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9UJZ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
30968 | STOML2 | GSM4909281 | Human | Breast | IDC | 4.34e-09 | 3.78e-01 | 0.21 |
30968 | STOML2 | GSM4909282 | Human | Breast | IDC | 1.61e-38 | 6.86e-01 | -0.0288 |
30968 | STOML2 | GSM4909285 | Human | Breast | IDC | 6.64e-19 | 4.19e-01 | 0.21 |
30968 | STOML2 | GSM4909288 | Human | Breast | IDC | 3.62e-09 | 4.12e-01 | 0.0988 |
30968 | STOML2 | GSM4909290 | Human | Breast | IDC | 2.28e-09 | 4.83e-01 | 0.2096 |
30968 | STOML2 | GSM4909292 | Human | Breast | IDC | 6.33e-10 | 7.66e-01 | 0.1236 |
30968 | STOML2 | GSM4909293 | Human | Breast | IDC | 5.19e-04 | 2.61e-01 | 0.1581 |
30968 | STOML2 | GSM4909296 | Human | Breast | IDC | 7.03e-11 | 8.27e-02 | 0.1524 |
30968 | STOML2 | GSM4909297 | Human | Breast | IDC | 1.70e-14 | -7.85e-02 | 0.1517 |
30968 | STOML2 | GSM4909304 | Human | Breast | IDC | 3.72e-07 | 3.50e-01 | 0.1636 |
30968 | STOML2 | GSM4909311 | Human | Breast | IDC | 2.73e-25 | -2.03e-01 | 0.1534 |
30968 | STOML2 | GSM4909312 | Human | Breast | IDC | 1.40e-08 | 5.91e-02 | 0.1552 |
30968 | STOML2 | GSM4909316 | Human | Breast | IDC | 3.61e-04 | 2.39e-03 | 0.21 |
30968 | STOML2 | GSM4909319 | Human | Breast | IDC | 3.17e-39 | -8.15e-02 | 0.1563 |
30968 | STOML2 | GSM4909320 | Human | Breast | IDC | 4.24e-07 | -3.95e-03 | 0.1575 |
30968 | STOML2 | GSM4909321 | Human | Breast | IDC | 3.41e-12 | -8.52e-02 | 0.1559 |
30968 | STOML2 | brca1 | Human | Breast | Precancer | 9.20e-09 | 3.94e-01 | -0.0338 |
30968 | STOML2 | brca2 | Human | Breast | Precancer | 3.19e-05 | 2.65e-01 | -0.024 |
30968 | STOML2 | brca3 | Human | Breast | Precancer | 6.80e-04 | 2.79e-01 | -0.0263 |
30968 | STOML2 | NCCBC14 | Human | Breast | DCIS | 3.36e-06 | -1.56e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:00061199 | Breast | Precancer | oxidative phosphorylation | 53/1080 | 141/18723 | 1.15e-29 | 2.04e-26 | 53 |
GO:00090608 | Breast | Precancer | aerobic respiration | 58/1080 | 189/18723 | 5.69e-27 | 7.62e-24 | 58 |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00453338 | Breast | Precancer | cellular respiration | 59/1080 | 230/18723 | 5.97e-23 | 5.32e-20 | 59 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:19026008 | Breast | Precancer | proton transmembrane transport | 39/1080 | 157/18723 | 4.18e-15 | 1.18e-12 | 39 |
GO:00159857 | Breast | Precancer | energy coupled proton transport, down electrochemical gradient | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00159867 | Breast | Precancer | ATP synthesis coupled proton transport | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00427766 | Breast | Precancer | mitochondrial ATP synthesis coupled proton transport | 13/1080 | 19/18723 | 1.43e-12 | 2.74e-10 | 13 |
GO:00067547 | Breast | Precancer | ATP biosynthetic process | 21/1080 | 57/18723 | 2.31e-12 | 4.26e-10 | 21 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00092067 | Breast | Precancer | purine ribonucleoside triphosphate biosynthetic process | 22/1080 | 68/18723 | 1.41e-11 | 1.88e-09 | 22 |
GO:00091457 | Breast | Precancer | purine nucleoside triphosphate biosynthetic process | 22/1080 | 69/18723 | 1.95e-11 | 2.43e-09 | 22 |
GO:00092017 | Breast | Precancer | ribonucleoside triphosphate biosynthetic process | 22/1080 | 74/18723 | 9.18e-11 | 1.00e-08 | 22 |
GO:00091448 | Breast | Precancer | purine nucleoside triphosphate metabolic process | 24/1080 | 88/18723 | 9.66e-11 | 1.03e-08 | 24 |
GO:00092057 | Breast | Precancer | purine ribonucleoside triphosphate metabolic process | 23/1080 | 82/18723 | 1.27e-10 | 1.34e-08 | 23 |
GO:00091427 | Breast | Precancer | nucleoside triphosphate biosynthetic process | 23/1080 | 85/18723 | 2.82e-10 | 2.69e-08 | 23 |
GO:00091997 | Breast | Precancer | ribonucleoside triphosphate metabolic process | 23/1080 | 89/18723 | 7.65e-10 | 6.66e-08 | 23 |
GO:00091418 | Breast | Precancer | nucleoside triphosphate metabolic process | 26/1080 | 112/18723 | 7.72e-10 | 6.66e-08 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STOML2 | SNV | Missense_Mutation | rs763483882 | c.215N>A | p.Arg72Gln | p.R72Q | Q9UJZ1 | protein_coding | tolerated(0.09) | benign(0.094) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
STOML2 | insertion | In_Frame_Ins | novel | c.116_117insACT | p.Leu39dup | p.L39dup | Q9UJZ1 | protein_coding | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
STOML2 | insertion | Frame_Shift_Ins | novel | c.116_117insA | p.Phe40ValfsTer49 | p.F40Vfs*49 | Q9UJZ1 | protein_coding | TCGA-KB-A93J-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
STOML2 | deletion | Frame_Shift_Del | novel | c.566_567delCT | p.Ser189TyrfsTer19 | p.S189Yfs*19 | Q9UJZ1 | protein_coding | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR | ||
STOML2 | SNV | Missense_Mutation | c.125C>T | p.Pro42Leu | p.P42L | Q9UJZ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EL-A3T9-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
STOML2 | SNV | Missense_Mutation | novel | c.331N>T | p.Asp111Tyr | p.D111Y | Q9UJZ1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STOML2 | SNV | Missense_Mutation | novel | c.602G>T | p.Arg201Leu | p.R201L | Q9UJZ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EM-A2CJ-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STOML2 | insertion | Frame_Shift_Ins | novel | c.133_134insT | p.Glu45ValfsTer44 | p.E45Vfs*44 | Q9UJZ1 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
STOML2 | insertion | In_Frame_Ins | novel | c.331_332insCTTCAA | p.Asp111delinsAlaSerAsn | p.D111delinsASN | Q9UJZ1 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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