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Gene: STK26 |
Gene summary for STK26 |
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Gene information | Species | Human | Gene symbol | STK26 | Gene ID | 51765 |
Gene name | serine/threonine kinase 26 | |
Gene Alias | MASK | |
Cytomap | Xq26.2 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q9P289 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51765 | STK26 | LZE4T | Human | Esophagus | ESCC | 7.99e-04 | 1.10e-01 | 0.0811 |
51765 | STK26 | LZE7T | Human | Esophagus | ESCC | 1.26e-08 | 5.19e-01 | 0.0667 |
51765 | STK26 | LZE24T | Human | Esophagus | ESCC | 5.72e-17 | 4.34e-01 | 0.0596 |
51765 | STK26 | LZE21T | Human | Esophagus | ESCC | 5.90e-04 | 1.81e-01 | 0.0655 |
51765 | STK26 | LZE6T | Human | Esophagus | ESCC | 1.33e-14 | 2.53e-01 | 0.0845 |
51765 | STK26 | P2T-E | Human | Esophagus | ESCC | 8.46e-17 | 3.59e-01 | 0.1177 |
51765 | STK26 | P4T-E | Human | Esophagus | ESCC | 7.48e-17 | 3.53e-01 | 0.1323 |
51765 | STK26 | P5T-E | Human | Esophagus | ESCC | 1.43e-12 | 1.40e-01 | 0.1327 |
51765 | STK26 | P8T-E | Human | Esophagus | ESCC | 2.41e-14 | 1.28e-01 | 0.0889 |
51765 | STK26 | P9T-E | Human | Esophagus | ESCC | 1.20e-09 | 2.23e-01 | 0.1131 |
51765 | STK26 | P10T-E | Human | Esophagus | ESCC | 8.24e-18 | 1.91e-01 | 0.116 |
51765 | STK26 | P12T-E | Human | Esophagus | ESCC | 9.81e-23 | 4.27e-01 | 0.1122 |
51765 | STK26 | P15T-E | Human | Esophagus | ESCC | 5.28e-07 | 9.05e-02 | 0.1149 |
51765 | STK26 | P16T-E | Human | Esophagus | ESCC | 4.15e-05 | 1.07e-02 | 0.1153 |
51765 | STK26 | P17T-E | Human | Esophagus | ESCC | 4.01e-08 | 1.49e-01 | 0.1278 |
51765 | STK26 | P20T-E | Human | Esophagus | ESCC | 2.09e-10 | 1.89e-01 | 0.1124 |
51765 | STK26 | P21T-E | Human | Esophagus | ESCC | 2.48e-09 | 1.12e-01 | 0.1617 |
51765 | STK26 | P22T-E | Human | Esophagus | ESCC | 1.44e-28 | 3.65e-01 | 0.1236 |
51765 | STK26 | P23T-E | Human | Esophagus | ESCC | 1.07e-08 | 3.65e-01 | 0.108 |
51765 | STK26 | P24T-E | Human | Esophagus | ESCC | 1.74e-12 | 2.27e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
GO:0031669110 | Esophagus | ESCC | cellular response to nutrient levels | 148/8552 | 215/18723 | 4.58e-12 | 1.76e-10 | 148 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:0009267110 | Esophagus | ESCC | cellular response to starvation | 110/8552 | 156/18723 | 2.63e-10 | 7.37e-09 | 110 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:00703018 | Esophagus | ESCC | cellular response to hydrogen peroxide | 68/8552 | 98/18723 | 1.70e-06 | 2.03e-05 | 68 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:003647320 | Esophagus | ESCC | cell death in response to oxidative stress | 59/8552 | 95/18723 | 9.12e-04 | 4.65e-03 | 59 |
GO:00300339 | Esophagus | ESCC | microvillus assembly | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:190288220 | Esophagus | ESCC | regulation of response to oxidative stress | 58/8552 | 98/18723 | 4.86e-03 | 1.88e-02 | 58 |
GO:190040720 | Esophagus | ESCC | regulation of cellular response to oxidative stress | 52/8552 | 89/18723 | 1.04e-02 | 3.56e-02 | 52 |
GO:190320120 | Esophagus | ESCC | regulation of oxidative stress-induced cell death | 44/8552 | 74/18723 | 1.18e-02 | 3.94e-02 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK26 | SNV | Missense_Mutation | novel | c.518N>G | p.Gln173Arg | p.Q173R | Q9P289 | protein_coding | tolerated(0.23) | benign(0.304) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK26 | SNV | Missense_Mutation | novel | c.536T>G | p.Phe179Cys | p.F179C | Q9P289 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK26 | SNV | Missense_Mutation | novel | c.77N>C | p.Lys26Thr | p.K26T | Q9P289 | protein_coding | tolerated(0.05) | benign(0.202) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
STK26 | SNV | Missense_Mutation | c.737C>A | p.Ser246Tyr | p.S246Y | Q9P289 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
STK26 | SNV | Missense_Mutation | novel | c.878N>T | p.Arg293Ile | p.R293I | Q9P289 | protein_coding | deleterious(0.01) | benign(0.125) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK26 | SNV | Missense_Mutation | c.697A>C | p.Lys233Gln | p.K233Q | Q9P289 | protein_coding | deleterious(0) | benign(0.374) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK26 | SNV | Missense_Mutation | rs777461974 | c.86N>A | p.Arg29His | p.R29H | Q9P289 | protein_coding | deleterious(0.05) | benign(0.102) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
STK26 | SNV | Missense_Mutation | novel | c.484N>A | p.Asp162Asn | p.D162N | Q9P289 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
STK26 | SNV | Missense_Mutation | c.1024G>T | p.Ala342Ser | p.A342S | Q9P289 | protein_coding | tolerated(0.22) | benign(0) | TCGA-50-6593-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
STK26 | SNV | Missense_Mutation | novel | c.273N>C | p.Lys91Asn | p.K91N | Q9P289 | protein_coding | deleterious(0.01) | possibly_damaging(0.587) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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