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Gene: STK11IP |
Gene summary for STK11IP |
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Gene information | Species | Human | Gene symbol | STK11IP | Gene ID | 114790 |
Gene name | serine/threonine kinase 11 interacting protein | |
Gene Alias | LIP1 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0008104 | UniProtAcc | C9JQV3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114790 | STK11IP | LZE24T | Human | Esophagus | ESCC | 8.56e-05 | 1.40e-01 | 0.0596 |
114790 | STK11IP | P2T-E | Human | Esophagus | ESCC | 1.56e-11 | 1.22e-01 | 0.1177 |
114790 | STK11IP | P8T-E | Human | Esophagus | ESCC | 2.61e-07 | 9.85e-02 | 0.0889 |
114790 | STK11IP | P10T-E | Human | Esophagus | ESCC | 6.74e-03 | 1.13e-01 | 0.116 |
114790 | STK11IP | P11T-E | Human | Esophagus | ESCC | 1.23e-02 | 2.06e-01 | 0.1426 |
114790 | STK11IP | P15T-E | Human | Esophagus | ESCC | 1.27e-09 | 1.18e-01 | 0.1149 |
114790 | STK11IP | P16T-E | Human | Esophagus | ESCC | 2.44e-07 | 1.59e-01 | 0.1153 |
114790 | STK11IP | P20T-E | Human | Esophagus | ESCC | 1.15e-03 | 9.78e-02 | 0.1124 |
114790 | STK11IP | P21T-E | Human | Esophagus | ESCC | 2.10e-05 | 1.37e-01 | 0.1617 |
114790 | STK11IP | P22T-E | Human | Esophagus | ESCC | 1.67e-02 | 5.09e-02 | 0.1236 |
114790 | STK11IP | P24T-E | Human | Esophagus | ESCC | 4.48e-03 | 6.87e-02 | 0.1287 |
114790 | STK11IP | P26T-E | Human | Esophagus | ESCC | 1.24e-03 | 8.75e-02 | 0.1276 |
114790 | STK11IP | P27T-E | Human | Esophagus | ESCC | 1.52e-06 | 1.30e-01 | 0.1055 |
114790 | STK11IP | P28T-E | Human | Esophagus | ESCC | 4.29e-03 | 1.15e-01 | 0.1149 |
114790 | STK11IP | P30T-E | Human | Esophagus | ESCC | 1.13e-02 | 1.72e-01 | 0.137 |
114790 | STK11IP | P32T-E | Human | Esophagus | ESCC | 3.19e-05 | 8.26e-02 | 0.1666 |
114790 | STK11IP | P37T-E | Human | Esophagus | ESCC | 1.36e-05 | 1.02e-01 | 0.1371 |
114790 | STK11IP | P40T-E | Human | Esophagus | ESCC | 2.09e-04 | 1.25e-01 | 0.109 |
114790 | STK11IP | P47T-E | Human | Esophagus | ESCC | 1.22e-02 | 5.03e-02 | 0.1067 |
114790 | STK11IP | P48T-E | Human | Esophagus | ESCC | 4.24e-03 | 6.53e-02 | 0.0959 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK11IP | SNV | Missense_Mutation | novel | c.1840C>A | p.Leu614Ile | p.L614I | protein_coding | deleterious(0.03) | benign(0.078) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
STK11IP | SNV | Missense_Mutation | novel | c.2372G>A | p.Arg791Gln | p.R791Q | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
STK11IP | SNV | Missense_Mutation | novel | c.529G>A | p.Ala177Thr | p.A177T | protein_coding | tolerated(0.2) | benign(0.052) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
STK11IP | SNV | Missense_Mutation | novel | c.2027G>A | p.Gly676Asp | p.G676D | protein_coding | deleterious(0.03) | probably_damaging(0.912) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
STK11IP | SNV | Missense_Mutation | novel | c.1762N>A | p.Ala588Thr | p.A588T | protein_coding | tolerated(0.08) | probably_damaging(0.96) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK11IP | SNV | Missense_Mutation | rs368637601 | c.1886N>A | p.Arg629His | p.R629H | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK11IP | SNV | Missense_Mutation | rs766821244 | c.3223N>A | p.Gly1075Arg | p.G1075R | protein_coding | tolerated(0.33) | benign(0.104) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK11IP | SNV | Missense_Mutation | novel | c.458N>A | p.Gly153Asp | p.G153D | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK11IP | SNV | Missense_Mutation | c.946N>C | p.Phe316Leu | p.F316L | protein_coding | tolerated(0.18) | benign(0.046) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
STK11IP | SNV | Missense_Mutation | c.1835N>A | p.Pro612His | p.P612H | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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