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Gene: STARD3 |
Gene summary for STARD3 |
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Gene information | Species | Human | Gene symbol | STARD3 | Gene ID | 10948 |
Gene name | StAR related lipid transfer domain containing 3 | |
Gene Alias | CAB1 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | Q14849 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10948 | STARD3 | GSM4909291 | Human | Breast | IDC | 3.20e-28 | 7.82e-01 | 0.1753 |
10948 | STARD3 | GSM4909292 | Human | Breast | IDC | 1.35e-13 | 9.25e-01 | 0.1236 |
10948 | STARD3 | GSM4909293 | Human | Breast | IDC | 8.68e-35 | 6.07e-01 | 0.1581 |
10948 | STARD3 | GSM4909294 | Human | Breast | IDC | 1.66e-02 | 2.35e-01 | 0.2022 |
10948 | STARD3 | GSM4909319 | Human | Breast | IDC | 9.90e-04 | -3.32e-02 | 0.1563 |
10948 | STARD3 | M2 | Human | Breast | IDC | 4.76e-18 | 1.00e+00 | 0.21 |
10948 | STARD3 | NCCBC14 | Human | Breast | DCIS | 2.15e-03 | 2.99e-01 | 0.2021 |
10948 | STARD3 | NCCBC5 | Human | Breast | DCIS | 1.72e-07 | 4.09e-01 | 0.2046 |
10948 | STARD3 | P2 | Human | Breast | IDC | 5.58e-07 | 4.57e-01 | 0.21 |
10948 | STARD3 | DCIS2 | Human | Breast | DCIS | 3.71e-13 | 2.94e-02 | 0.0085 |
10948 | STARD3 | LZE4T | Human | Esophagus | ESCC | 9.73e-12 | 2.22e-01 | 0.0811 |
10948 | STARD3 | LZE5T | Human | Esophagus | ESCC | 2.93e-02 | 2.12e-01 | 0.0514 |
10948 | STARD3 | LZE7T | Human | Esophagus | ESCC | 3.56e-07 | 6.05e-01 | 0.0667 |
10948 | STARD3 | LZE8T | Human | Esophagus | ESCC | 3.20e-04 | 2.29e-01 | 0.067 |
10948 | STARD3 | LZE20T | Human | Esophagus | ESCC | 4.47e-02 | 1.19e-01 | 0.0662 |
10948 | STARD3 | LZE22T | Human | Esophagus | ESCC | 2.36e-05 | 4.23e-01 | 0.068 |
10948 | STARD3 | LZE24T | Human | Esophagus | ESCC | 2.92e-24 | 7.11e-01 | 0.0596 |
10948 | STARD3 | LZE6T | Human | Esophagus | ESCC | 1.13e-04 | 4.10e-01 | 0.0845 |
10948 | STARD3 | P1T-E | Human | Esophagus | ESCC | 2.96e-09 | 4.73e-01 | 0.0875 |
10948 | STARD3 | P2T-E | Human | Esophagus | ESCC | 3.19e-29 | 4.53e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:00066944 | Breast | IDC | steroid biosynthetic process | 25/1434 | 173/18723 | 1.56e-03 | 1.56e-02 | 25 |
GO:000683923 | Breast | DCIS | mitochondrial transport | 51/1390 | 254/18723 | 5.04e-11 | 6.79e-09 | 51 |
GO:000669411 | Breast | DCIS | steroid biosynthetic process | 23/1390 | 173/18723 | 4.63e-03 | 3.52e-02 | 23 |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:005165010 | Esophagus | HGIN | establishment of vesicle localization | 35/2587 | 161/18723 | 3.89e-03 | 3.54e-02 | 35 |
GO:005164810 | Esophagus | HGIN | vesicle localization | 37/2587 | 177/18723 | 6.03e-03 | 4.87e-02 | 37 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00069038 | Esophagus | ESCC | vesicle targeting | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:19026524 | Esophagus | ESCC | secondary alcohol metabolic process | 87/8552 | 147/18723 | 6.58e-04 | 3.50e-03 | 87 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00990222 | Esophagus | ESCC | vesicle tethering | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:00082034 | Esophagus | ESCC | cholesterol metabolic process | 79/8552 | 137/18723 | 3.11e-03 | 1.29e-02 | 79 |
GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049794 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa049795 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STARD3 | SNV | Missense_Mutation | novel | c.997N>A | p.Val333Met | p.V333M | Q14849 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
STARD3 | SNV | Missense_Mutation | novel | c.289G>T | p.Asp97Tyr | p.D97Y | Q14849 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STARD3 | SNV | Missense_Mutation | rs201876420 | c.1021N>A | p.Val341Met | p.V341M | Q14849 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-CV-7104-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STARD3 | SNV | Missense_Mutation | novel | c.901N>T | p.Ile301Phe | p.I301F | Q14849 | protein_coding | tolerated(0.23) | possibly_damaging(0.513) | TCGA-UF-A7J9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STARD3 | SNV | Missense_Mutation | c.1049T>C | p.Val350Ala | p.V350A | Q14849 | protein_coding | tolerated(0.08) | possibly_damaging(0.642) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
STARD3 | SNV | Missense_Mutation | rs149648909 | c.128N>A | p.Arg43Gln | p.R43Q | Q14849 | protein_coding | tolerated(0.12) | benign(0.255) | TCGA-HU-8238-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | didox | SD |
STARD3 | SNV | Missense_Mutation | c.67G>T | p.Gly23Cys | p.G23C | Q14849 | protein_coding | deleterious(0.01) | benign(0.371) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
STARD3 | SNV | Missense_Mutation | c.484N>A | p.Ala162Thr | p.A162T | Q14849 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
STARD3 | SNV | Missense_Mutation | c.79N>G | p.Ser27Ala | p.S27A | Q14849 | protein_coding | deleterious(0.01) | benign(0.079) | TCGA-KS-A4I9-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | cytomel | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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