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Gene: STARD10 |
Gene summary for STARD10 |
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Gene information | Species | Human | Gene symbol | STARD10 | Gene ID | 10809 |
Gene name | StAR related lipid transfer domain containing 10 | |
Gene Alias | CGI-52 | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R5L8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10809 | STARD10 | GSM4909285 | Human | Breast | IDC | 1.04e-07 | -2.86e-01 | 0.21 |
10809 | STARD10 | GSM4909290 | Human | Breast | IDC | 2.14e-19 | 6.43e-01 | 0.2096 |
10809 | STARD10 | GSM4909291 | Human | Breast | IDC | 1.52e-07 | 4.50e-01 | 0.1753 |
10809 | STARD10 | GSM4909294 | Human | Breast | IDC | 2.16e-04 | 4.22e-01 | 0.2022 |
10809 | STARD10 | GSM4909296 | Human | Breast | IDC | 4.57e-03 | -1.78e-01 | 0.1524 |
10809 | STARD10 | GSM4909297 | Human | Breast | IDC | 1.42e-06 | 1.02e-01 | 0.1517 |
10809 | STARD10 | GSM4909301 | Human | Breast | IDC | 8.87e-24 | 6.83e-01 | 0.1577 |
10809 | STARD10 | GSM4909304 | Human | Breast | IDC | 7.61e-93 | 1.32e+00 | 0.1636 |
10809 | STARD10 | GSM4909309 | Human | Breast | IDC | 1.51e-02 | 1.42e-01 | 0.0483 |
10809 | STARD10 | GSM4909311 | Human | Breast | IDC | 2.19e-14 | -1.62e-01 | 0.1534 |
10809 | STARD10 | GSM4909313 | Human | Breast | IDC | 4.32e-12 | 4.63e-01 | 0.0391 |
10809 | STARD10 | GSM4909315 | Human | Breast | IDC | 3.93e-12 | 5.55e-01 | 0.21 |
10809 | STARD10 | GSM4909316 | Human | Breast | IDC | 3.37e-19 | 7.85e-01 | 0.21 |
10809 | STARD10 | GSM4909317 | Human | Breast | IDC | 7.24e-28 | 7.22e-01 | 0.1355 |
10809 | STARD10 | GSM4909318 | Human | Breast | IDC | 5.88e-25 | 1.10e+00 | 0.2031 |
10809 | STARD10 | GSM4909319 | Human | Breast | IDC | 1.49e-36 | 4.42e-01 | 0.1563 |
10809 | STARD10 | GSM4909320 | Human | Breast | IDC | 7.75e-18 | 5.49e-01 | 0.1575 |
10809 | STARD10 | GSM4909321 | Human | Breast | IDC | 4.67e-30 | 7.49e-01 | 0.1559 |
10809 | STARD10 | M1 | Human | Breast | IDC | 2.15e-27 | 7.95e-01 | 0.1577 |
10809 | STARD10 | NCCBC11 | Human | Breast | DCIS | 3.37e-14 | 6.06e-01 | 0.1232 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
GO:00108764 | Stomach | SIM | lipid localization | 30/708 | 448/18723 | 1.87e-03 | 2.08e-02 | 30 |
GO:00068693 | Stomach | SIM | lipid transport | 27/708 | 398/18723 | 2.58e-03 | 2.55e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STARD10 | SNV | Missense_Mutation | rs757623133 | c.334G>A | p.Ala112Thr | p.A112T | Q9Y365 | protein_coding | tolerated(0.08) | benign(0.364) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
STARD10 | SNV | Missense_Mutation | c.442N>C | p.Tyr148His | p.Y148H | Q9Y365 | protein_coding | tolerated(0.43) | benign(0.03) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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