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Gene: SOX9 |
Gene summary for SOX9 |
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Gene information | Species | Human | Gene symbol | SOX9 | Gene ID | 6662 |
Gene name | SRY-box transcription factor 9 | |
Gene Alias | CMD1 | |
Cytomap | 17q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P48436 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6662 | SOX9 | GSM4909280 | Human | Breast | Precancer | 8.81e-06 | 5.75e-01 | 0.0305 |
6662 | SOX9 | GSM4909282 | Human | Breast | IDC | 4.00e-24 | 6.87e-01 | -0.0288 |
6662 | SOX9 | GSM4909285 | Human | Breast | IDC | 2.14e-04 | 2.36e-01 | 0.21 |
6662 | SOX9 | GSM4909286 | Human | Breast | IDC | 2.55e-04 | 1.64e-01 | 0.1081 |
6662 | SOX9 | GSM4909287 | Human | Breast | IDC | 9.55e-05 | 3.29e-01 | 0.2057 |
6662 | SOX9 | GSM4909295 | Human | Breast | IDC | 7.27e-10 | 5.86e-01 | 0.0898 |
6662 | SOX9 | GSM4909296 | Human | Breast | IDC | 1.79e-05 | -2.39e-01 | 0.1524 |
6662 | SOX9 | GSM4909297 | Human | Breast | IDC | 1.59e-07 | -3.16e-01 | 0.1517 |
6662 | SOX9 | GSM4909298 | Human | Breast | IDC | 1.34e-24 | 6.51e-01 | 0.1551 |
6662 | SOX9 | GSM4909299 | Human | Breast | IDC | 6.81e-06 | 4.30e-01 | 0.035 |
6662 | SOX9 | GSM4909300 | Human | Breast | IDC | 1.22e-02 | 4.14e-01 | 0.0334 |
6662 | SOX9 | GSM4909301 | Human | Breast | IDC | 1.64e-02 | -2.69e-01 | 0.1577 |
6662 | SOX9 | GSM4909311 | Human | Breast | IDC | 4.78e-16 | -2.44e-01 | 0.1534 |
6662 | SOX9 | GSM4909312 | Human | Breast | IDC | 1.84e-04 | -1.48e-01 | 0.1552 |
6662 | SOX9 | GSM4909313 | Human | Breast | IDC | 1.41e-02 | 2.76e-01 | 0.0391 |
6662 | SOX9 | GSM4909319 | Human | Breast | IDC | 3.49e-23 | -3.80e-01 | 0.1563 |
6662 | SOX9 | GSM4909320 | Human | Breast | IDC | 9.99e-07 | -4.23e-01 | 0.1575 |
6662 | SOX9 | GSM4909321 | Human | Breast | IDC | 1.51e-16 | -3.69e-01 | 0.1559 |
6662 | SOX9 | NCCBC14 | Human | Breast | DCIS | 9.01e-07 | 1.76e-01 | 0.2021 |
6662 | SOX9 | NCCBC5 | Human | Breast | DCIS | 2.85e-10 | -3.52e-01 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421769 | Breast | Precancer | regulation of protein catabolic process | 47/1080 | 391/18723 | 1.50e-06 | 5.58e-05 | 47 |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00106348 | Breast | Precancer | positive regulation of epithelial cell migration | 25/1080 | 176/18723 | 2.75e-05 | 6.21e-04 | 25 |
GO:00106319 | Breast | Precancer | epithelial cell migration | 40/1080 | 357/18723 | 4.57e-05 | 9.71e-04 | 40 |
GO:00901329 | Breast | Precancer | epithelium migration | 40/1080 | 360/18723 | 5.51e-05 | 1.14e-03 | 40 |
GO:00506736 | Breast | Precancer | epithelial cell proliferation | 46/1080 | 437/18723 | 6.02e-05 | 1.23e-03 | 46 |
GO:00901309 | Breast | Precancer | tissue migration | 40/1080 | 365/18723 | 7.48e-05 | 1.47e-03 | 40 |
GO:00712147 | Breast | Precancer | cellular response to abiotic stimulus | 37/1080 | 331/18723 | 9.12e-05 | 1.73e-03 | 37 |
GO:01040047 | Breast | Precancer | cellular response to environmental stimulus | 37/1080 | 331/18723 | 9.12e-05 | 1.73e-03 | 37 |
GO:00488729 | Breast | Precancer | homeostasis of number of cells | 32/1080 | 272/18723 | 1.03e-04 | 1.89e-03 | 32 |
GO:00018898 | Breast | Precancer | liver development | 21/1080 | 147/18723 | 1.08e-04 | 1.96e-03 | 21 |
GO:00610088 | Breast | Precancer | hepaticobiliary system development | 21/1080 | 150/18723 | 1.45e-04 | 2.49e-03 | 21 |
GO:00106329 | Breast | Precancer | regulation of epithelial cell migration | 33/1080 | 292/18723 | 1.74e-04 | 2.86e-03 | 33 |
GO:00506786 | Breast | Precancer | regulation of epithelial cell proliferation | 40/1080 | 381/18723 | 1.88e-04 | 3.03e-03 | 40 |
GO:00016678 | Breast | Precancer | ameboidal-type cell migration | 47/1080 | 475/18723 | 2.19e-04 | 3.35e-03 | 47 |
GO:00486087 | Breast | Precancer | reproductive structure development | 43/1080 | 424/18723 | 2.36e-04 | 3.56e-03 | 43 |
GO:00098969 | Breast | Precancer | positive regulation of catabolic process | 48/1080 | 492/18723 | 2.62e-04 | 3.84e-03 | 48 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00614587 | Breast | Precancer | reproductive system development | 43/1080 | 427/18723 | 2.75e-04 | 4.00e-03 | 43 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa040241 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa040242 | Colorectum | CRC | cAMP signaling pathway | 47/1091 | 225/8465 | 4.57e-04 | 4.77e-03 | 3.23e-03 | 47 |
hsa040243 | Colorectum | CRC | cAMP signaling pathway | 47/1091 | 225/8465 | 4.57e-04 | 4.77e-03 | 3.23e-03 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX9 | insertion | Frame_Shift_Ins | novel | c.1134_1135dupGG | p.Ala379GlyfsTer5 | p.A379Gfs*5 | P48436 | protein_coding | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.1481_1482insC | p.Gln496ProfsTer82 | p.Q496Pfs*82 | P48436 | protein_coding | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.866_867insC | p.Asp290ArgfsTer6 | p.D290Rfs*6 | P48436 | protein_coding | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.767_768dupGG | p.Arg257GlyfsTer23 | p.R257Gfs*23 | P48436 | protein_coding | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.766_770dupGGGCG | p.Pro258GlyfsTer23 | p.P258Gfs*23 | P48436 | protein_coding | TCGA-AD-6890-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.183_184insA | p.Glu63GlyfsTer189 | p.E63Gfs*189 | P48436 | protein_coding | TCGA-AY-6386-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fu | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.1183_1184insCG | p.His396ArgfsTer8 | p.H396Rfs*8 | P48436 | protein_coding | TCGA-AY-A54L-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.764_765insG | p.Arg257AlafsTer39 | p.R257Afs*39 | P48436 | protein_coding | TCGA-AZ-4681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.1237_1238insTG | p.His413LeufsTer58 | p.H413Lfs*58 | P48436 | protein_coding | TCGA-CA-5255-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | ||
SOX9 | insertion | Frame_Shift_Ins | novel | c.1348_1351dupTCCT | p.Tyr451PhefsTer128 | p.Y451Ffs*128 | P48436 | protein_coding | TCGA-CK-4947-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Other, specify in notes | folinic | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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