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Gene: SOS1 |
Gene summary for SOS1 |
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Gene information | Species | Human | Gene symbol | SOS1 | Gene ID | 6654 |
Gene name | SOS Ras/Rac guanine nucleotide exchange factor 1 | |
Gene Alias | GF1 | |
Cytomap | 2p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q07889 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6654 | SOS1 | CCI_1 | Human | Cervix | CC | 1.84e-05 | 1.14e+00 | 0.528 |
6654 | SOS1 | CCI_2 | Human | Cervix | CC | 8.82e-14 | 1.52e+00 | 0.5249 |
6654 | SOS1 | CCI_3 | Human | Cervix | CC | 8.21e-15 | 9.67e-01 | 0.516 |
6654 | SOS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.20e-24 | -6.35e-01 | 0.0155 |
6654 | SOS1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.97e-05 | -6.82e-01 | 0.0216 |
6654 | SOS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.65e-03 | 4.39e-01 | -0.1954 |
6654 | SOS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.96e-02 | -4.07e-01 | -0.1207 |
6654 | SOS1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.04e-02 | -6.04e-01 | 0.0451 |
6654 | SOS1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.00e-04 | -3.24e-01 | 0.0528 |
6654 | SOS1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.22e-02 | -2.04e-01 | 0.294 |
6654 | SOS1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.48e-03 | 7.77e-01 | 0.3487 |
6654 | SOS1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.83e-07 | -3.96e-01 | 0.3005 |
6654 | SOS1 | F007 | Human | Colorectum | FAP | 4.05e-02 | -2.61e-01 | 0.1176 |
6654 | SOS1 | A001-C-207 | Human | Colorectum | FAP | 4.50e-05 | -2.67e-01 | 0.1278 |
6654 | SOS1 | A015-C-203 | Human | Colorectum | FAP | 1.40e-37 | -5.92e-01 | -0.1294 |
6654 | SOS1 | A015-C-204 | Human | Colorectum | FAP | 1.12e-11 | -4.84e-01 | -0.0228 |
6654 | SOS1 | A014-C-040 | Human | Colorectum | FAP | 1.71e-06 | -4.92e-01 | -0.1184 |
6654 | SOS1 | A002-C-201 | Human | Colorectum | FAP | 3.40e-22 | -5.24e-01 | 0.0324 |
6654 | SOS1 | A001-C-119 | Human | Colorectum | FAP | 3.30e-18 | -7.46e-01 | -0.1557 |
6654 | SOS1 | A001-C-108 | Human | Colorectum | FAP | 1.95e-23 | -4.59e-01 | -0.0272 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:00509007 | Cervix | CC | leukocyte migration | 78/2311 | 369/18723 | 1.09e-06 | 3.80e-05 | 78 |
GO:00420988 | Cervix | CC | T cell proliferation | 49/2311 | 199/18723 | 1.32e-06 | 4.49e-05 | 49 |
GO:00020111 | Cervix | CC | morphogenesis of an epithelial sheet | 21/2311 | 57/18723 | 1.91e-06 | 5.97e-05 | 21 |
GO:004887210 | Cervix | CC | homeostasis of number of cells | 61/2311 | 272/18723 | 2.17e-06 | 6.55e-05 | 61 |
GO:00421297 | Cervix | CC | regulation of T cell proliferation | 43/2311 | 171/18723 | 3.21e-06 | 8.77e-05 | 43 |
GO:00380933 | Cervix | CC | Fc receptor signaling pathway | 19/2311 | 50/18723 | 3.42e-06 | 9.17e-05 | 19 |
GO:19021056 | Cervix | CC | regulation of leukocyte differentiation | 61/2311 | 279/18723 | 5.16e-06 | 1.29e-04 | 61 |
GO:00706637 | Cervix | CC | regulation of leukocyte proliferation | 55/2311 | 245/18723 | 6.51e-06 | 1.56e-04 | 55 |
GO:00506705 | Cervix | CC | regulation of lymphocyte proliferation | 51/2311 | 225/18723 | 1.05e-05 | 2.32e-04 | 51 |
GO:00329444 | Cervix | CC | regulation of mononuclear cell proliferation | 51/2311 | 227/18723 | 1.36e-05 | 2.73e-04 | 51 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520820 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0491520 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa0401210 | Cervix | CC | ErbB signaling pathway | 28/1267 | 85/8465 | 2.40e-05 | 1.82e-04 | 1.08e-04 | 28 |
hsa0521010 | Cervix | CC | Colorectal cancer | 27/1267 | 86/8465 | 8.60e-05 | 5.57e-04 | 3.30e-04 | 27 |
hsa052148 | Cervix | CC | Glioma | 24/1267 | 75/8465 | 1.51e-04 | 9.20e-04 | 5.44e-04 | 24 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa04664 | Cervix | CC | Fc epsilon RI signaling pathway | 22/1267 | 68/8465 | 2.35e-04 | 1.31e-03 | 7.77e-04 | 22 |
hsa015223 | Cervix | CC | Endocrine resistance | 28/1267 | 98/8465 | 3.82e-04 | 1.87e-03 | 1.11e-03 | 28 |
hsa0472214 | Cervix | CC | Neurotrophin signaling pathway | 32/1267 | 119/8465 | 5.01e-04 | 2.42e-03 | 1.43e-03 | 32 |
hsa052157 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0491212 | Cervix | CC | GnRH signaling pathway | 26/1267 | 93/8465 | 8.72e-04 | 3.87e-03 | 2.29e-03 | 26 |
hsa0521310 | Cervix | CC | Endometrial cancer | 18/1267 | 58/8465 | 1.46e-03 | 6.30e-03 | 3.73e-03 | 18 |
hsa052234 | Cervix | CC | Non-small cell lung cancer | 21/1267 | 72/8465 | 1.48e-03 | 6.32e-03 | 3.74e-03 | 21 |
hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa052119 | Cervix | CC | Renal cell carcinoma | 20/1267 | 69/8465 | 2.07e-03 | 8.17e-03 | 4.83e-03 | 20 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOS1 | SNV | Missense_Mutation | c.371N>G | p.His124Arg | p.H124R | Q07889 | protein_coding | tolerated(0.19) | benign(0.164) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SOS1 | SNV | Missense_Mutation | novel | c.2144N>G | p.Glu715Gly | p.E715G | Q07889 | protein_coding | tolerated(0.06) | possibly_damaging(0.692) | TCGA-DM-A282-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOS1 | SNV | Missense_Mutation | c.239N>G | p.His80Arg | p.H80R | Q07889 | protein_coding | tolerated(0.2) | benign(0.034) | TCGA-F4-6463-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOS1 | SNV | Missense_Mutation | c.278C>A | p.Ala93Asp | p.A93D | Q07889 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOS1 | SNV | Missense_Mutation | c.1496T>A | p.Val499Glu | p.V499E | Q07889 | protein_coding | deleterious(0) | possibly_damaging(0.663) | TCGA-AG-4008-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
SOS1 | SNV | Missense_Mutation | rs777373438 | c.3697N>A | p.Leu1233Ile | p.L1233I | Q07889 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.952) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SOS1 | SNV | Missense_Mutation | rs374497013 | c.3610N>G | p.Ile1204Val | p.I1204V | Q07889 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-CI-6622-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
SOS1 | SNV | Missense_Mutation | c.1727G>A | p.Arg576Lys | p.R576K | Q07889 | protein_coding | tolerated(0.35) | benign(0.429) | TCGA-DC-6682-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOS1 | SNV | Missense_Mutation | novel | c.1474G>A | p.Glu492Lys | p.E492K | Q07889 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
SOS1 | SNV | Missense_Mutation | novel | c.1175C>T | p.Ser392Phe | p.S392F | Q07889 | protein_coding | deleterious(0.01) | possibly_damaging(0.807) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6654 | SOS1 | KINASE | 385612239 | |||
6654 | SOS1 | KINASE | IL-6 | 9815779 |
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