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Gene: SOCS4 |
Gene summary for SOCS4 |
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Gene information | Species | Human | Gene symbol | SOCS4 | Gene ID | 122809 |
Gene name | suppressor of cytokine signaling 4 | |
Gene Alias | SOCS7 | |
Cytomap | 14q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q5H9R6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
122809 | SOCS4 | LZE4T | Human | Esophagus | ESCC | 1.01e-08 | 2.32e-01 | 0.0811 |
122809 | SOCS4 | LZE5T | Human | Esophagus | ESCC | 2.25e-02 | 4.18e-01 | 0.0514 |
122809 | SOCS4 | LZE7T | Human | Esophagus | ESCC | 2.95e-04 | 1.83e-01 | 0.0667 |
122809 | SOCS4 | LZE20T | Human | Esophagus | ESCC | 4.27e-03 | 1.05e-01 | 0.0662 |
122809 | SOCS4 | LZE24T | Human | Esophagus | ESCC | 9.43e-10 | 1.57e-01 | 0.0596 |
122809 | SOCS4 | LZE6T | Human | Esophagus | ESCC | 8.16e-03 | 1.40e-01 | 0.0845 |
122809 | SOCS4 | P1T-E | Human | Esophagus | ESCC | 1.63e-05 | 1.74e-01 | 0.0875 |
122809 | SOCS4 | P2T-E | Human | Esophagus | ESCC | 8.84e-10 | 1.50e-01 | 0.1177 |
122809 | SOCS4 | P4T-E | Human | Esophagus | ESCC | 7.40e-17 | 3.39e-01 | 0.1323 |
122809 | SOCS4 | P5T-E | Human | Esophagus | ESCC | 1.47e-08 | 1.58e-01 | 0.1327 |
122809 | SOCS4 | P8T-E | Human | Esophagus | ESCC | 5.23e-12 | 2.01e-01 | 0.0889 |
122809 | SOCS4 | P9T-E | Human | Esophagus | ESCC | 3.05e-10 | 1.34e-01 | 0.1131 |
122809 | SOCS4 | P10T-E | Human | Esophagus | ESCC | 8.50e-18 | 3.37e-01 | 0.116 |
122809 | SOCS4 | P11T-E | Human | Esophagus | ESCC | 6.45e-03 | 1.30e-01 | 0.1426 |
122809 | SOCS4 | P12T-E | Human | Esophagus | ESCC | 4.25e-12 | 2.17e-01 | 0.1122 |
122809 | SOCS4 | P15T-E | Human | Esophagus | ESCC | 2.06e-22 | 4.60e-01 | 0.1149 |
122809 | SOCS4 | P16T-E | Human | Esophagus | ESCC | 8.05e-06 | 1.05e-01 | 0.1153 |
122809 | SOCS4 | P17T-E | Human | Esophagus | ESCC | 4.15e-07 | 2.66e-01 | 0.1278 |
122809 | SOCS4 | P20T-E | Human | Esophagus | ESCC | 3.09e-04 | 9.84e-02 | 0.1124 |
122809 | SOCS4 | P21T-E | Human | Esophagus | ESCC | 7.91e-06 | 1.64e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:0032434111 | Esophagus | ESCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 107/8552 | 134/18723 | 4.06e-16 | 2.93e-14 | 107 |
GO:2000058111 | Esophagus | ESCC | regulation of ubiquitin-dependent protein catabolic process | 125/8552 | 164/18723 | 1.17e-15 | 7.76e-14 | 125 |
GO:1903364111 | Esophagus | ESCC | positive regulation of cellular protein catabolic process | 117/8552 | 155/18723 | 3.25e-14 | 1.66e-12 | 117 |
GO:1901800110 | Esophagus | ESCC | positive regulation of proteasomal protein catabolic process | 91/8552 | 114/18723 | 6.74e-14 | 3.34e-12 | 91 |
GO:1903052110 | Esophagus | ESCC | positive regulation of proteolysis involved in cellular protein catabolic process | 101/8552 | 133/18723 | 9.58e-13 | 4.19e-11 | 101 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0051348111 | Esophagus | ESCC | negative regulation of transferase activity | 177/8552 | 268/18723 | 1.08e-11 | 4.00e-10 | 177 |
GO:0032436111 | Esophagus | ESCC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 72/8552 | 90/18723 | 2.30e-11 | 7.87e-10 | 72 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0491014 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0491041 | Liver | HCC | Insulin signaling pathway | 95/4020 | 137/8465 | 1.53e-07 | 1.97e-06 | 1.10e-06 | 95 |
hsa04917 | Liver | HCC | Prolactin signaling pathway | 43/4020 | 70/8465 | 1.30e-02 | 3.19e-02 | 1.78e-02 | 43 |
hsa0491051 | Liver | HCC | Insulin signaling pathway | 95/4020 | 137/8465 | 1.53e-07 | 1.97e-06 | 1.10e-06 | 95 |
hsa049171 | Liver | HCC | Prolactin signaling pathway | 43/4020 | 70/8465 | 1.30e-02 | 3.19e-02 | 1.78e-02 | 43 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOCS4 | SNV | Missense_Mutation | c.950N>G | p.Asp317Gly | p.D317G | Q8WXH5 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SOCS4 | SNV | Missense_Mutation | c.250C>T | p.His84Tyr | p.H84Y | Q8WXH5 | protein_coding | deleterious(0.04) | possibly_damaging(0.842) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
SOCS4 | SNV | Missense_Mutation | rs749753893 | c.986N>A | p.Arg329His | p.R329H | Q8WXH5 | protein_coding | deleterious(0) | benign(0.107) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
SOCS4 | insertion | Frame_Shift_Ins | novel | c.119_120insA | p.Ser43GlufsTer2 | p.S43Efs*2 | Q8WXH5 | protein_coding | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | ||
SOCS4 | SNV | Missense_Mutation | novel | c.957N>T | p.Leu319Phe | p.L319F | Q8WXH5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SOCS4 | insertion | Nonsense_Mutation | novel | c.113_114insCAGATTCTAATGTTATAAA | p.Trp39ArgfsTer3 | p.W39Rfs*3 | Q8WXH5 | protein_coding | TCGA-DJ-A3VK-01 | Thyroid | thyroid carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
SOCS4 | insertion | Nonsense_Mutation | novel | c.113_114insCAGATTCTAATGTTATAAATACTGCTT | p.Ser38_Trp39insArgPheTerCysTyrLysTyrCysPhe | p.S38_W39insRF*CYKYCF | Q8WXH5 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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