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Gene: SNX15 |
Gene summary for SNX15 |
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Gene information | Species | Human | Gene symbol | SNX15 | Gene ID | 29907 |
Gene name | sorting nexin 15 | |
Gene Alias | HSAF001435 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | E5KQS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29907 | SNX15 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.44e-05 | 1.62e-01 | -0.1808 |
29907 | SNX15 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.67e-02 | 1.27e-01 | -0.0811 |
29907 | SNX15 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.38e-10 | 2.49e-01 | -0.1088 |
29907 | SNX15 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.00e-27 | 4.68e-01 | -0.1954 |
29907 | SNX15 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.94e-01 | -0.2602 |
29907 | SNX15 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.91e-05 | 2.13e-01 | -0.1207 |
29907 | SNX15 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.73e-04 | 2.58e-01 | -0.1526 |
29907 | SNX15 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.44e-12 | 2.36e-01 | -0.1464 |
29907 | SNX15 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.52e-13 | 2.52e-01 | -0.1001 |
29907 | SNX15 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.17e-15 | 3.32e-01 | -0.059 |
29907 | SNX15 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.72e-05 | 3.10e-01 | -0.1706 |
29907 | SNX15 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.03e-03 | 1.93e-01 | -0.2061 |
29907 | SNX15 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.34e-04 | 3.36e-01 | -0.1462 |
29907 | SNX15 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.71e-06 | 2.90e-01 | -0.0842 |
29907 | SNX15 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.84e-09 | 2.28e-01 | 0.096 |
29907 | SNX15 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-02 | 1.93e-01 | 0.0446 |
29907 | SNX15 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.26e-01 | 0.0528 |
29907 | SNX15 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 2.06e-01 | 0.0171 |
29907 | SNX15 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.05e-06 | 1.48e-01 | 0.0674 |
29907 | SNX15 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.39e-03 | 2.90e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX15 | SNV | Missense_Mutation | c.688N>G | p.His230Asp | p.H230D | Q9NRS6 | protein_coding | deleterious(0.03) | benign(0.053) | TCGA-66-2755-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SNX15 | SNV | Missense_Mutation | novel | c.179N>C | p.Gly60Ala | p.G60A | Q9NRS6 | protein_coding | tolerated(0.1) | possibly_damaging(0.698) | TCGA-85-A4JC-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
SNX15 | SNV | Missense_Mutation | novel | c.61C>G | p.His21Asp | p.H21D | Q9NRS6 | protein_coding | deleterious(0.01) | possibly_damaging(0.858) | TCGA-D6-A4ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
SNX15 | SNV | Missense_Mutation | novel | c.94N>C | p.Ala32Pro | p.A32P | Q9NRS6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
SNX15 | SNV | Missense_Mutation | rs771422309 | c.370N>T | p.Arg124Trp | p.R124W | Q9NRS6 | protein_coding | deleterious(0) | benign(0.096) | TCGA-EJ-5507-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
SNX15 | SNV | Missense_Mutation | c.443C>T | p.Thr148Ile | p.T148I | Q9NRS6 | protein_coding | tolerated(0.18) | benign(0.265) | TCGA-CD-5813-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SNX15 | SNV | Missense_Mutation | rs760147028 | c.151N>T | p.Arg51Trp | p.R51W | Q9NRS6 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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