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Gene: SNRPA |
Gene summary for SNRPA |
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Gene information | Species | Human | Gene symbol | SNRPA | Gene ID | 6626 |
Gene name | small nuclear ribonucleoprotein polypeptide A | |
Gene Alias | Mud1 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P09012 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6626 | SNRPA | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.68e-03 | 1.22e-01 | 0.0155 |
6626 | SNRPA | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.37e-03 | 3.61e-01 | -0.1207 |
6626 | SNRPA | HTA11_696_2000001011 | Human | Colorectum | AD | 2.43e-11 | 4.19e-01 | -0.1464 |
6626 | SNRPA | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.65e-07 | 5.73e-01 | -0.059 |
6626 | SNRPA | HTA11_866_3004761011 | Human | Colorectum | AD | 1.52e-02 | 2.79e-01 | 0.096 |
6626 | SNRPA | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.01e-04 | 4.71e-01 | 0.0446 |
6626 | SNRPA | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.89e-14 | 4.41e-01 | 0.0674 |
6626 | SNRPA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.59e-02 | 2.65e-01 | 0.294 |
6626 | SNRPA | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.11e-08 | 4.65e-01 | 0.3859 |
6626 | SNRPA | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.90e-03 | 1.97e-01 | 0.3005 |
6626 | SNRPA | LZE4T | Human | Esophagus | ESCC | 1.67e-05 | 3.09e-01 | 0.0811 |
6626 | SNRPA | LZE7T | Human | Esophagus | ESCC | 5.37e-17 | 1.03e+00 | 0.0667 |
6626 | SNRPA | LZE8T | Human | Esophagus | ESCC | 3.34e-08 | 4.53e-01 | 0.067 |
6626 | SNRPA | LZE22T | Human | Esophagus | ESCC | 1.33e-03 | 8.12e-01 | 0.068 |
6626 | SNRPA | LZE24T | Human | Esophagus | ESCC | 4.35e-13 | 5.41e-01 | 0.0596 |
6626 | SNRPA | LZE6T | Human | Esophagus | ESCC | 1.51e-08 | 5.13e-01 | 0.0845 |
6626 | SNRPA | P1T-E | Human | Esophagus | ESCC | 5.07e-08 | 8.69e-01 | 0.0875 |
6626 | SNRPA | P2T-E | Human | Esophagus | ESCC | 3.03e-45 | 9.68e-01 | 0.1177 |
6626 | SNRPA | P4T-E | Human | Esophagus | ESCC | 2.34e-35 | 1.29e+00 | 0.1323 |
6626 | SNRPA | P5T-E | Human | Esophagus | ESCC | 1.56e-64 | 1.29e+00 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00003981 | Colorectum | SER | mRNA splicing, via spliceosome | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNRPA | SNV | Missense_Mutation | rs771537539 | c.454N>T | p.Arg152Cys | p.R152C | P09012 | protein_coding | deleterious(0.04) | possibly_damaging(0.63) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
SNRPA | SNV | Missense_Mutation | rs750149923 | c.809N>T | p.Thr270Met | p.T270M | P09012 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNRPA | SNV | Missense_Mutation | novel | c.728N>A | p.Arg243Gln | p.R243Q | P09012 | protein_coding | deleterious(0) | benign(0.013) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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