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Gene: SLC6A8 |
Gene summary for SLC6A8 |
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Gene information | Species | Human | Gene symbol | SLC6A8 | Gene ID | 6535 |
Gene name | solute carrier family 6 member 8 | |
Gene Alias | CCDS1 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P48029 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6535 | SLC6A8 | CA_HPV_2 | Human | Cervix | CC | 3.30e-03 | 2.14e-01 | 0.0391 |
6535 | SLC6A8 | CA_HPV_3 | Human | Cervix | CC | 5.53e-03 | 8.31e-02 | 0.0414 |
6535 | SLC6A8 | Tumor | Human | Cervix | CC | 2.45e-20 | 5.13e-01 | 0.1241 |
6535 | SLC6A8 | sample1 | Human | Cervix | CC | 4.13e-07 | 4.99e-01 | 0.0959 |
6535 | SLC6A8 | sample3 | Human | Cervix | CC | 5.03e-43 | 7.97e-01 | 0.1387 |
6535 | SLC6A8 | T1 | Human | Cervix | CC | 1.89e-11 | 4.60e-01 | 0.0918 |
6535 | SLC6A8 | T3 | Human | Cervix | CC | 2.05e-36 | 7.67e-01 | 0.1389 |
6535 | SLC6A8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.75e-17 | 1.02e+00 | -0.1808 |
6535 | SLC6A8 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.53e-02 | 2.91e-01 | -0.1954 |
6535 | SLC6A8 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.53e-05 | 1.30e+00 | -0.2602 |
6535 | SLC6A8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.14e-05 | 1.34e+00 | -0.2196 |
6535 | SLC6A8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.63e-03 | 3.36e-01 | -0.1207 |
6535 | SLC6A8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.08e-09 | 4.10e-01 | -0.1464 |
6535 | SLC6A8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.63e-04 | 3.36e-01 | -0.059 |
6535 | SLC6A8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.10e-06 | 1.19e+00 | -0.2061 |
6535 | SLC6A8 | LZE2T | Human | Esophagus | ESCC | 1.09e-05 | 6.54e-01 | 0.082 |
6535 | SLC6A8 | LZE4T | Human | Esophagus | ESCC | 9.08e-12 | 3.03e-01 | 0.0811 |
6535 | SLC6A8 | LZE7T | Human | Esophagus | ESCC | 3.55e-14 | 9.95e-01 | 0.0667 |
6535 | SLC6A8 | LZE20T | Human | Esophagus | ESCC | 1.45e-06 | 6.72e-01 | 0.0662 |
6535 | SLC6A8 | LZE22T | Human | Esophagus | ESCC | 1.16e-02 | 3.99e-01 | 0.068 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:000657521 | Liver | HCC | cellular modified amino acid metabolic process | 119/7958 | 188/18723 | 6.47e-09 | 1.67e-07 | 119 |
GO:00065756 | Oral cavity | OSCC | cellular modified amino acid metabolic process | 91/7305 | 188/18723 | 5.33e-03 | 2.07e-02 | 91 |
GO:00065758 | Skin | cSCC | cellular modified amino acid metabolic process | 73/4864 | 188/18723 | 7.11e-05 | 6.85e-04 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC6A8 | SNV | Missense_Mutation | novel | c.695N>C | p.Asn232Thr | p.N232T | P48029 | protein_coding | deleterious(0) | benign(0.405) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC6A8 | SNV | Missense_Mutation | novel | c.1595N>C | p.Met532Thr | p.M532T | P48029 | protein_coding | tolerated(0.55) | benign(0.017) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC6A8 | SNV | Missense_Mutation | novel | c.518G>A | p.Gly173Asp | p.G173D | P48029 | protein_coding | tolerated(0.61) | benign(0.013) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC6A8 | SNV | Missense_Mutation | c.863N>T | p.Gly288Val | p.G288V | P48029 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-6776-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC6A8 | SNV | Missense_Mutation | novel | c.985A>T | p.Ser329Cys | p.S329C | P48029 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-5931-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SLC6A8 | SNV | Missense_Mutation | c.517G>A | p.Gly173Ser | p.G173S | P48029 | protein_coding | tolerated(0.22) | benign(0.141) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
SLC6A8 | SNV | Missense_Mutation | c.1674N>T | p.Glu558Asp | p.E558D | P48029 | protein_coding | tolerated(0.59) | benign(0.056) | TCGA-93-7347-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC6A8 | SNV | Missense_Mutation | novel | c.1530N>T | p.Met510Ile | p.M510I | P48029 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-43-8118-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
SLC6A8 | SNV | Missense_Mutation | c.1371C>G | p.Ile457Met | p.I457M | P48029 | protein_coding | tolerated(0.06) | possibly_damaging(0.557) | TCGA-46-3765-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC6A8 | SNV | Missense_Mutation | rs782582776 | c.1602C>G | p.Ile534Met | p.I534M | P48029 | protein_coding | tolerated(0.07) | possibly_damaging(0.506) | TCGA-CV-5978-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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