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Gene: SLC52A2 |
Gene summary for SLC52A2 |
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Gene information | Species | Human | Gene symbol | SLC52A2 | Gene ID | 79581 |
Gene name | solute carrier family 52 member 2 | |
Gene Alias | BVVLS2 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006766 | UniProtAcc | Q9HAB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79581 | SLC52A2 | GSM4909281 | Human | Breast | IDC | 6.45e-21 | 5.74e-01 | 0.21 |
79581 | SLC52A2 | GSM4909285 | Human | Breast | IDC | 4.13e-09 | 3.13e-01 | 0.21 |
79581 | SLC52A2 | GSM4909311 | Human | Breast | IDC | 5.96e-07 | 7.38e-02 | 0.1534 |
79581 | SLC52A2 | GSM4909312 | Human | Breast | IDC | 4.84e-09 | 3.93e-01 | 0.1552 |
79581 | SLC52A2 | GSM4909317 | Human | Breast | IDC | 2.94e-04 | 3.35e-01 | 0.1355 |
79581 | SLC52A2 | GSM4909319 | Human | Breast | IDC | 2.56e-16 | 1.24e-01 | 0.1563 |
79581 | SLC52A2 | GSM4909321 | Human | Breast | IDC | 7.53e-03 | 2.24e-01 | 0.1559 |
79581 | SLC52A2 | brca1 | Human | Breast | Precancer | 6.20e-03 | 2.94e-01 | -0.0338 |
79581 | SLC52A2 | brca2 | Human | Breast | Precancer | 2.85e-06 | 2.65e-01 | -0.024 |
79581 | SLC52A2 | NCCBC5 | Human | Breast | DCIS | 3.16e-03 | 2.77e-02 | 0.2046 |
79581 | SLC52A2 | P1 | Human | Breast | IDC | 1.23e-02 | -1.15e-01 | 0.1527 |
79581 | SLC52A2 | DCIS2 | Human | Breast | DCIS | 1.14e-30 | 8.19e-02 | 0.0085 |
79581 | SLC52A2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.24e-02 | 3.26e-01 | -0.1808 |
79581 | SLC52A2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.05e-04 | 4.10e-01 | -0.0811 |
79581 | SLC52A2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.80e-04 | 2.51e-01 | -0.1954 |
79581 | SLC52A2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.38e-03 | 5.98e-01 | -0.2196 |
79581 | SLC52A2 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.04e-04 | 2.37e-01 | -0.1464 |
79581 | SLC52A2 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.13e-05 | 2.02e-01 | -0.1001 |
79581 | SLC52A2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.57e-09 | 5.41e-01 | -0.059 |
79581 | SLC52A2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.70e-07 | 2.91e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00521269 | Breast | Precancer | movement in host environment | 29/1080 | 175/18723 | 2.59e-07 | 1.28e-05 | 29 |
GO:00517019 | Breast | Precancer | biological process involved in interaction with host | 31/1080 | 203/18723 | 6.52e-07 | 2.71e-05 | 31 |
GO:00444099 | Breast | Precancer | entry into host | 25/1080 | 151/18723 | 1.74e-06 | 6.19e-05 | 25 |
GO:00467189 | Breast | Precancer | viral entry into host cell | 24/1080 | 144/18723 | 2.46e-06 | 8.35e-05 | 24 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:005212614 | Breast | IDC | movement in host environment | 32/1434 | 175/18723 | 3.33e-06 | 1.22e-04 | 32 |
GO:005170114 | Breast | IDC | biological process involved in interaction with host | 35/1434 | 203/18723 | 4.72e-06 | 1.63e-04 | 35 |
GO:004440914 | Breast | IDC | entry into host | 28/1434 | 151/18723 | 1.02e-05 | 2.82e-04 | 28 |
GO:004671814 | Breast | IDC | viral entry into host cell | 27/1434 | 144/18723 | 1.18e-05 | 3.14e-04 | 27 |
GO:001603224 | Breast | DCIS | viral process | 73/1390 | 415/18723 | 3.40e-12 | 6.88e-10 | 73 |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:005212624 | Breast | DCIS | movement in host environment | 31/1390 | 175/18723 | 4.93e-06 | 1.45e-04 | 31 |
GO:005170124 | Breast | DCIS | biological process involved in interaction with host | 34/1390 | 203/18723 | 6.30e-06 | 1.78e-04 | 34 |
GO:004440924 | Breast | DCIS | entry into host | 27/1390 | 151/18723 | 1.65e-05 | 4.00e-04 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC52A2 | SNV | Missense_Mutation | rs781928955 | c.577N>A | p.Ala193Thr | p.A193T | Q9HAB3 | protein_coding | tolerated(0.25) | benign(0.37) | TCGA-CN-6992-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
SLC52A2 | SNV | Missense_Mutation | novel | c.1141N>G | p.Leu381Val | p.L381V | Q9HAB3 | protein_coding | tolerated(0.08) | benign(0.168) | TCGA-CR-7390-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC52A2 | SNV | Missense_Mutation | novel | c.1003N>C | p.Ser335Pro | p.S335P | Q9HAB3 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC52A2 | SNV | Missense_Mutation | rs782269382 | c.556G>A | p.Asp186Asn | p.D186N | Q9HAB3 | protein_coding | tolerated(0.58) | benign(0) | TCGA-EJ-A8FN-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
SLC52A2 | SNV | Missense_Mutation | rs781928955 | c.577G>A | p.Ala193Thr | p.A193T | Q9HAB3 | protein_coding | tolerated(0.25) | benign(0.37) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC52A2 | SNV | Missense_Mutation | rs560681538 | c.425N>A | p.Arg142His | p.R142H | Q9HAB3 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC52A2 | SNV | Missense_Mutation | c.749N>C | p.Leu250Pro | p.L250P | Q9HAB3 | protein_coding | deleterious(0.03) | probably_damaging(0.942) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC52A2 | SNV | Missense_Mutation | c.1129N>A | p.Leu377Met | p.L377M | Q9HAB3 | protein_coding | deleterious(0.03) | benign(0.053) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC52A2 | SNV | Missense_Mutation | novel | c.1235N>C | p.Ile412Thr | p.I412T | Q9HAB3 | protein_coding | tolerated(0.14) | benign(0.056) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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