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Gene: SLC4A11 |
Gene summary for SLC4A11 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLC4A11 | Gene ID | 83959 |
Gene name | solute carrier family 4 member 11 | |
Gene Alias | BTR1 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NBS3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83959 | SLC4A11 | LZE7T | Human | Esophagus | ESCC | 6.67e-06 | 3.53e-01 | 0.0667 |
83959 | SLC4A11 | P2T-E | Human | Esophagus | ESCC | 5.76e-04 | -1.03e-01 | 0.1177 |
83959 | SLC4A11 | P4T-E | Human | Esophagus | ESCC | 9.57e-05 | 6.49e-03 | 0.1323 |
83959 | SLC4A11 | P8T-E | Human | Esophagus | ESCC | 4.58e-10 | 9.88e-02 | 0.0889 |
83959 | SLC4A11 | P9T-E | Human | Esophagus | ESCC | 1.25e-02 | -6.78e-02 | 0.1131 |
83959 | SLC4A11 | P10T-E | Human | Esophagus | ESCC | 6.48e-07 | -3.07e-02 | 0.116 |
83959 | SLC4A11 | P12T-E | Human | Esophagus | ESCC | 8.03e-12 | 2.30e-01 | 0.1122 |
83959 | SLC4A11 | P16T-E | Human | Esophagus | ESCC | 1.08e-07 | -1.16e-02 | 0.1153 |
83959 | SLC4A11 | P22T-E | Human | Esophagus | ESCC | 1.60e-04 | -1.20e-01 | 0.1236 |
83959 | SLC4A11 | P23T-E | Human | Esophagus | ESCC | 1.14e-05 | 1.47e-01 | 0.108 |
83959 | SLC4A11 | P24T-E | Human | Esophagus | ESCC | 4.92e-06 | -8.38e-02 | 0.1287 |
83959 | SLC4A11 | P26T-E | Human | Esophagus | ESCC | 2.01e-14 | 4.02e-01 | 0.1276 |
83959 | SLC4A11 | P27T-E | Human | Esophagus | ESCC | 6.84e-08 | 1.92e-01 | 0.1055 |
83959 | SLC4A11 | P28T-E | Human | Esophagus | ESCC | 5.02e-14 | 2.50e-01 | 0.1149 |
83959 | SLC4A11 | P30T-E | Human | Esophagus | ESCC | 4.22e-05 | 2.64e-01 | 0.137 |
83959 | SLC4A11 | P31T-E | Human | Esophagus | ESCC | 7.58e-05 | 1.36e-01 | 0.1251 |
83959 | SLC4A11 | P32T-E | Human | Esophagus | ESCC | 1.80e-02 | -1.30e-01 | 0.1666 |
83959 | SLC4A11 | P40T-E | Human | Esophagus | ESCC | 4.16e-02 | 3.57e-02 | 0.109 |
83959 | SLC4A11 | P42T-E | Human | Esophagus | ESCC | 4.34e-04 | -1.92e-02 | 0.1175 |
83959 | SLC4A11 | P47T-E | Human | Esophagus | ESCC | 2.16e-04 | -9.02e-02 | 0.1067 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:00069707 | Esophagus | ESCC | response to osmotic stress | 57/8552 | 84/18723 | 3.26e-05 | 2.70e-04 | 57 |
GO:005188110 | Esophagus | ESCC | regulation of mitochondrial membrane potential | 51/8552 | 74/18723 | 4.42e-05 | 3.51e-04 | 51 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:00714707 | Esophagus | ESCC | cellular response to osmotic stress | 31/8552 | 41/18723 | 9.32e-05 | 6.68e-04 | 31 |
GO:200073614 | Esophagus | ESCC | regulation of stem cell differentiation | 39/8552 | 58/18723 | 7.43e-04 | 3.86e-03 | 39 |
GO:0006971 | Esophagus | ESCC | hypotonic response | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:190260018 | Esophagus | ESCC | proton transmembrane transport | 88/8552 | 157/18723 | 5.62e-03 | 2.10e-02 | 88 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC4A11 | SNV | Missense_Mutation | novel | c.934N>T | p.Leu312Phe | p.L312F | Q8NBS3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC4A11 | SNV | Missense_Mutation | novel | c.748G>A | p.Ala250Thr | p.A250T | Q8NBS3 | protein_coding | tolerated(0.93) | benign(0.02) | TCGA-AJ-A3BD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SLC4A11 | SNV | Missense_Mutation | rs766567944 | c.2492N>A | p.Arg831His | p.R831H | Q8NBS3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SLC4A11 | SNV | Missense_Mutation | novel | c.2059N>A | p.Gly687Ser | p.G687S | Q8NBS3 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SLC4A11 | SNV | Missense_Mutation | novel | c.604N>T | p.Leu202Phe | p.L202F | Q8NBS3 | protein_coding | tolerated(0.21) | benign(0.041) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
SLC4A11 | SNV | Missense_Mutation | novel | c.466N>A | p.Asp156Asn | p.D156N | Q8NBS3 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC4A11 | SNV | Missense_Mutation | c.1564G>A | p.Ala522Thr | p.A522T | Q8NBS3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC4A11 | SNV | Missense_Mutation | rs544270581 | c.2620N>A | p.Gly874Ser | p.G874S | Q8NBS3 | protein_coding | deleterious(0.02) | possibly_damaging(0.828) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC4A11 | SNV | Missense_Mutation | novel | c.1733N>T | p.Ala578Val | p.A578V | Q8NBS3 | protein_coding | tolerated(0.4) | benign(0.044) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC4A11 | SNV | Missense_Mutation | novel | c.1504G>A | p.Ala502Thr | p.A502T | Q8NBS3 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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