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Gene: SLC38A5 |
Gene summary for SLC38A5 |
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Gene information | Species | Human | Gene symbol | SLC38A5 | Gene ID | 92745 |
Gene name | solute carrier family 38 member 5 | |
Gene Alias | JM24 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A024QYY0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92745 | SLC38A5 | P2T-E | Human | Esophagus | ESCC | 3.95e-02 | -5.43e-02 | 0.1177 |
92745 | SLC38A5 | P4T-E | Human | Esophagus | ESCC | 4.76e-16 | 4.61e-01 | 0.1323 |
92745 | SLC38A5 | P5T-E | Human | Esophagus | ESCC | 3.01e-02 | 2.06e-01 | 0.1327 |
92745 | SLC38A5 | P9T-E | Human | Esophagus | ESCC | 2.45e-04 | 1.80e-01 | 0.1131 |
92745 | SLC38A5 | P10T-E | Human | Esophagus | ESCC | 6.62e-26 | 5.48e-01 | 0.116 |
92745 | SLC38A5 | P11T-E | Human | Esophagus | ESCC | 3.20e-19 | 1.67e+00 | 0.1426 |
92745 | SLC38A5 | P12T-E | Human | Esophagus | ESCC | 3.76e-07 | 1.54e-01 | 0.1122 |
92745 | SLC38A5 | P21T-E | Human | Esophagus | ESCC | 1.75e-61 | 1.30e+00 | 0.1617 |
92745 | SLC38A5 | P24T-E | Human | Esophagus | ESCC | 4.39e-12 | 3.30e-01 | 0.1287 |
92745 | SLC38A5 | P26T-E | Human | Esophagus | ESCC | 1.16e-19 | 5.59e-01 | 0.1276 |
92745 | SLC38A5 | P27T-E | Human | Esophagus | ESCC | 3.10e-19 | 7.97e-01 | 0.1055 |
92745 | SLC38A5 | P31T-E | Human | Esophagus | ESCC | 2.03e-33 | 7.49e-01 | 0.1251 |
92745 | SLC38A5 | P37T-E | Human | Esophagus | ESCC | 1.30e-39 | 1.20e+00 | 0.1371 |
92745 | SLC38A5 | P44T-E | Human | Esophagus | ESCC | 4.33e-04 | 4.56e-01 | 0.1096 |
92745 | SLC38A5 | P49T-E | Human | Esophagus | ESCC | 1.56e-08 | 1.11e+00 | 0.1768 |
92745 | SLC38A5 | P52T-E | Human | Esophagus | ESCC | 8.93e-06 | 3.57e-01 | 0.1555 |
92745 | SLC38A5 | P62T-E | Human | Esophagus | ESCC | 2.98e-31 | 9.36e-01 | 0.1302 |
92745 | SLC38A5 | P65T-E | Human | Esophagus | ESCC | 6.25e-10 | 3.78e-01 | 0.0978 |
92745 | SLC38A5 | P74T-E | Human | Esophagus | ESCC | 2.27e-20 | 7.59e-01 | 0.1479 |
92745 | SLC38A5 | P89T-E | Human | Esophagus | ESCC | 2.09e-07 | 7.17e-01 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032329 | Oral cavity | OSCC | serine transport | 9/7305 | 11/18723 | 4.85e-03 | 1.92e-02 | 9 |
GO:00323291 | Oral cavity | LP | serine transport | 7/4623 | 11/18723 | 7.01e-03 | 3.96e-02 | 7 |
GO:00323292 | Thyroid | ATC | serine transport | 8/6293 | 11/18723 | 9.31e-03 | 3.44e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC38A5 | SNV | Missense_Mutation | novel | c.574N>A | p.Gly192Ser | p.G192S | Q8WUX1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC38A5 | SNV | Missense_Mutation | novel | c.358N>A | p.Gly120Arg | p.G120R | Q8WUX1 | protein_coding | deleterious(0.05) | probably_damaging(0.944) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC38A5 | SNV | Missense_Mutation | novel | c.763N>T | p.Asp255Tyr | p.D255Y | Q8WUX1 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
SLC38A5 | SNV | Missense_Mutation | c.1249N>T | p.Pro417Ser | p.P417S | Q8WUX1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
SLC38A5 | SNV | Missense_Mutation | c.1094N>G | p.Leu365Arg | p.L365R | Q8WUX1 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
SLC38A5 | SNV | Missense_Mutation | c.740N>A | p.Cys247Tyr | p.C247Y | Q8WUX1 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-97-7547-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | vinorelbine | PD | |
SLC38A5 | SNV | Missense_Mutation | c.100N>A | p.Pro34Thr | p.P34T | Q8WUX1 | protein_coding | tolerated(0.3) | benign(0) | TCGA-97-A4M3-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLC38A5 | SNV | Missense_Mutation | c.1366G>T | p.Gly456Cys | p.G456C | Q8WUX1 | protein_coding | tolerated(0.09) | probably_damaging(0.95) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC38A5 | SNV | Missense_Mutation | novel | c.788N>T | p.Pro263Leu | p.P263L | Q8WUX1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-4587-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | etoposide | PD |
SLC38A5 | SNV | Missense_Mutation | novel | c.706G>T | p.Val236Leu | p.V236L | Q8WUX1 | protein_coding | tolerated(0.77) | benign(0.001) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
92745 | SLC38A5 | TRANSPORTER | 178101385 | |||
92745 | SLC38A5 | TRANSPORTER | 178101341 |
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