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Gene: SLC29A2 |
Gene summary for SLC29A2 |
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Gene information | Species | Human | Gene symbol | SLC29A2 | Gene ID | 3177 |
Gene name | solute carrier family 29 member 2 | |
Gene Alias | DER12 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001504 | UniProtAcc | Q14542 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3177 | SLC29A2 | LZE24T | Human | Esophagus | ESCC | 5.13e-07 | 1.10e-01 | 0.0596 |
3177 | SLC29A2 | P2T-E | Human | Esophagus | ESCC | 1.58e-06 | 1.74e-01 | 0.1177 |
3177 | SLC29A2 | P4T-E | Human | Esophagus | ESCC | 2.67e-17 | 4.10e-01 | 0.1323 |
3177 | SLC29A2 | P5T-E | Human | Esophagus | ESCC | 8.68e-30 | 5.63e-01 | 0.1327 |
3177 | SLC29A2 | P8T-E | Human | Esophagus | ESCC | 2.14e-06 | 1.31e-01 | 0.0889 |
3177 | SLC29A2 | P12T-E | Human | Esophagus | ESCC | 4.79e-04 | 1.28e-01 | 0.1122 |
3177 | SLC29A2 | P15T-E | Human | Esophagus | ESCC | 1.54e-16 | 3.80e-01 | 0.1149 |
3177 | SLC29A2 | P16T-E | Human | Esophagus | ESCC | 2.53e-03 | 1.53e-01 | 0.1153 |
3177 | SLC29A2 | P23T-E | Human | Esophagus | ESCC | 1.77e-09 | 2.32e-01 | 0.108 |
3177 | SLC29A2 | P24T-E | Human | Esophagus | ESCC | 9.56e-06 | 1.22e-01 | 0.1287 |
3177 | SLC29A2 | P26T-E | Human | Esophagus | ESCC | 1.76e-04 | 1.54e-01 | 0.1276 |
3177 | SLC29A2 | P28T-E | Human | Esophagus | ESCC | 3.40e-22 | 5.57e-01 | 0.1149 |
3177 | SLC29A2 | P30T-E | Human | Esophagus | ESCC | 9.53e-03 | 1.08e-01 | 0.137 |
3177 | SLC29A2 | P37T-E | Human | Esophagus | ESCC | 1.35e-07 | 2.17e-01 | 0.1371 |
3177 | SLC29A2 | P47T-E | Human | Esophagus | ESCC | 1.26e-02 | 7.88e-02 | 0.1067 |
3177 | SLC29A2 | P49T-E | Human | Esophagus | ESCC | 2.64e-05 | 4.80e-01 | 0.1768 |
3177 | SLC29A2 | P52T-E | Human | Esophagus | ESCC | 9.58e-05 | 1.74e-01 | 0.1555 |
3177 | SLC29A2 | P54T-E | Human | Esophagus | ESCC | 3.37e-06 | 2.00e-01 | 0.0975 |
3177 | SLC29A2 | P56T-E | Human | Esophagus | ESCC | 2.80e-04 | 6.27e-01 | 0.1613 |
3177 | SLC29A2 | P57T-E | Human | Esophagus | ESCC | 7.62e-06 | 1.75e-01 | 0.0926 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC29A2 | SNV | Missense_Mutation | rs774663200 | c.1294G>A | p.Ala432Thr | p.A432T | Q14542 | protein_coding | tolerated(0.19) | benign(0.03) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC29A2 | SNV | Missense_Mutation | c.1273N>T | p.His425Tyr | p.H425Y | Q14542 | protein_coding | deleterious(0.01) | benign(0.209) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SLC29A2 | SNV | Missense_Mutation | novel | c.1150T>C | p.Ser384Pro | p.S384P | Q14542 | protein_coding | tolerated(0.2) | benign(0.283) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SLC29A2 | SNV | Missense_Mutation | c.253C>A | p.Leu85Ile | p.L85I | Q14542 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC29A2 | SNV | Missense_Mutation | novel | c.1213N>A | p.Val405Ile | p.V405I | Q14542 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-HU-8244-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3177 | SLC29A2 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | gemcitabine | GEMCITABINE | 25162786 | |
3177 | SLC29A2 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | TECADENOSON | TECADENOSON | 23388705 | |
3177 | SLC29A2 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | 6-MERCAPTOPURINE | MERCAPTOPURINE | 17088032 |
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