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Gene: SLC25A21 |
Gene summary for SLC25A21 |
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Gene information | Species | Human | Gene symbol | SLC25A21 | Gene ID | 89874 |
Gene name | solute carrier family 25 member 21 | |
Gene Alias | MTDPS18 | |
Cytomap | 14q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9BQT8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89874 | SLC25A21 | RNA-P17T-P17T-2 | Human | Lung | IAC | 6.80e-05 | 6.76e-01 | 0.3371 |
89874 | SLC25A21 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.13e-06 | 7.77e-01 | 0.343 |
89874 | SLC25A21 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.13e-06 | 6.00e-01 | 0.3385 |
89874 | SLC25A21 | RNA-P17T-P17T-8 | Human | Lung | IAC | 5.44e-06 | 6.23e-01 | 0.3329 |
89874 | SLC25A21 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.15e-03 | 3.05e-01 | -0.2119 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19905426 | Lung | IAC | mitochondrial transmembrane transport | 21/2061 | 102/18723 | 3.34e-03 | 2.86e-02 | 21 |
GO:199054213 | Lung | AIS | mitochondrial transmembrane transport | 20/1849 | 102/18723 | 2.12e-03 | 2.30e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A21 | SNV | Missense_Mutation | novel | c.523N>G | p.Thr175Ala | p.T175A | Q9BQT8 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC25A21 | SNV | Missense_Mutation | novel | c.736A>G | p.Lys246Glu | p.K246E | Q9BQT8 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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