![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC12A9 |
Gene summary for SLC12A9 |
![]() |
Gene information | Species | Human | Gene symbol | SLC12A9 | Gene ID | 56996 |
Gene name | solute carrier family 12 member 9 | |
Gene Alias | CCC6 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9BXP2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56996 | SLC12A9 | LZE22T | Human | Esophagus | ESCC | 1.21e-03 | 3.61e-01 | 0.068 |
56996 | SLC12A9 | LZE24T | Human | Esophagus | ESCC | 4.20e-10 | 2.76e-01 | 0.0596 |
56996 | SLC12A9 | P1T-E | Human | Esophagus | ESCC | 7.27e-13 | 4.51e-01 | 0.0875 |
56996 | SLC12A9 | P2T-E | Human | Esophagus | ESCC | 4.05e-58 | 8.88e-01 | 0.1177 |
56996 | SLC12A9 | P4T-E | Human | Esophagus | ESCC | 3.25e-10 | 2.07e-01 | 0.1323 |
56996 | SLC12A9 | P5T-E | Human | Esophagus | ESCC | 1.25e-08 | 9.82e-02 | 0.1327 |
56996 | SLC12A9 | P8T-E | Human | Esophagus | ESCC | 1.22e-16 | 2.87e-01 | 0.0889 |
56996 | SLC12A9 | P9T-E | Human | Esophagus | ESCC | 1.45e-11 | 2.56e-01 | 0.1131 |
56996 | SLC12A9 | P10T-E | Human | Esophagus | ESCC | 2.79e-16 | 2.88e-01 | 0.116 |
56996 | SLC12A9 | P11T-E | Human | Esophagus | ESCC | 3.13e-06 | 2.66e-01 | 0.1426 |
56996 | SLC12A9 | P12T-E | Human | Esophagus | ESCC | 5.03e-22 | 4.52e-01 | 0.1122 |
56996 | SLC12A9 | P15T-E | Human | Esophagus | ESCC | 1.83e-28 | 5.67e-01 | 0.1149 |
56996 | SLC12A9 | P16T-E | Human | Esophagus | ESCC | 3.83e-27 | 4.59e-01 | 0.1153 |
56996 | SLC12A9 | P17T-E | Human | Esophagus | ESCC | 2.68e-02 | 1.78e-01 | 0.1278 |
56996 | SLC12A9 | P19T-E | Human | Esophagus | ESCC | 1.20e-05 | 3.47e-01 | 0.1662 |
56996 | SLC12A9 | P20T-E | Human | Esophagus | ESCC | 5.35e-36 | 6.02e-01 | 0.1124 |
56996 | SLC12A9 | P21T-E | Human | Esophagus | ESCC | 4.23e-28 | 4.65e-01 | 0.1617 |
56996 | SLC12A9 | P22T-E | Human | Esophagus | ESCC | 2.24e-06 | 1.37e-01 | 0.1236 |
56996 | SLC12A9 | P23T-E | Human | Esophagus | ESCC | 7.55e-36 | 7.92e-01 | 0.108 |
56996 | SLC12A9 | P24T-E | Human | Esophagus | ESCC | 5.97e-11 | 2.35e-01 | 0.1287 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:003253519 | Oral cavity | OSCC | regulation of cellular component size | 201/7305 | 383/18723 | 4.80e-08 | 8.88e-07 | 201 |
GO:00083618 | Oral cavity | OSCC | regulation of cell size | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:0032535110 | Oral cavity | LP | regulation of cellular component size | 128/4623 | 383/18723 | 6.56e-05 | 8.80e-04 | 128 |
GO:0032535111 | Skin | cSCC | regulation of cellular component size | 131/4864 | 383/18723 | 1.89e-04 | 1.59e-03 | 131 |
GO:0032535112 | Thyroid | PTC | regulation of cellular component size | 181/5968 | 383/18723 | 1.70e-10 | 5.64e-09 | 181 |
GO:000836115 | Thyroid | PTC | regulation of cell size | 83/5968 | 181/18723 | 5.45e-05 | 4.84e-04 | 83 |
GO:003253526 | Thyroid | ATC | regulation of cellular component size | 191/6293 | 383/18723 | 2.51e-11 | 8.69e-10 | 191 |
GO:000836122 | Thyroid | ATC | regulation of cell size | 89/6293 | 181/18723 | 1.01e-05 | 1.00e-04 | 89 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC12A9 | SNV | Missense_Mutation | novel | c.1490G>T | p.Gly497Val | p.G497V | Q9BXP2 | protein_coding | tolerated(0.14) | benign(0.105) | TCGA-AJ-A8CV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC12A9 | SNV | Missense_Mutation | rs200686276 | c.1429G>A | p.Ala477Thr | p.A477T | Q9BXP2 | protein_coding | deleterious(0.02) | benign(0.112) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC12A9 | SNV | Missense_Mutation | c.68N>T | p.Ala23Val | p.A23V | Q9BXP2 | protein_coding | tolerated(0.22) | benign(0.029) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC12A9 | SNV | Missense_Mutation | novel | c.1058N>T | p.Thr353Ile | p.T353I | Q9BXP2 | protein_coding | deleterious(0) | possibly_damaging(0.58) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC12A9 | SNV | Missense_Mutation | novel | c.1775N>A | p.Ala592Asp | p.A592D | Q9BXP2 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC12A9 | SNV | Missense_Mutation | novel | c.1852G>T | p.Gly618Cys | p.G618C | Q9BXP2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SLC12A9 | SNV | Missense_Mutation | c.934G>A | p.Val312Ile | p.V312I | Q9BXP2 | protein_coding | tolerated(0.85) | benign(0.007) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC12A9 | SNV | Missense_Mutation | rs542732755 | c.187G>A | p.Val63Met | p.V63M | Q9BXP2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC12A9 | SNV | Missense_Mutation | rs758697064 | c.1897N>A | p.Asp633Asn | p.D633N | Q9BXP2 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC12A9 | SNV | Missense_Mutation | c.2079N>T | p.Met693Ile | p.M693I | Q9BXP2 | protein_coding | deleterious(0.01) | benign(0.298) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |