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Gene: SLC12A7 |
Gene summary for SLC12A7 |
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Gene information | Species | Human | Gene symbol | SLC12A7 | Gene ID | 10723 |
Gene name | solute carrier family 12 member 7 | |
Gene Alias | KCC4 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y666 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10723 | SLC12A7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.63e-03 | 1.72e-01 | 0.0155 |
10723 | SLC12A7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.90e-07 | 4.07e-01 | -0.1808 |
10723 | SLC12A7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.42e-10 | 6.06e-01 | -0.0811 |
10723 | SLC12A7 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.57e-02 | 3.15e-01 | -0.1088 |
10723 | SLC12A7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.03e-14 | 4.37e-01 | -0.1954 |
10723 | SLC12A7 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.66e-03 | 5.84e-01 | -0.2602 |
10723 | SLC12A7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.23e-07 | 4.55e-01 | -0.1207 |
10723 | SLC12A7 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.12e-08 | 5.71e-01 | -0.1526 |
10723 | SLC12A7 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.11e-11 | 4.50e-01 | -0.1464 |
10723 | SLC12A7 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.46e-10 | 4.37e-01 | -0.1001 |
10723 | SLC12A7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.11e-22 | 8.08e-01 | -0.059 |
10723 | SLC12A7 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.46e-02 | 3.34e-01 | -0.0842 |
10723 | SLC12A7 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.20e-12 | 4.98e-01 | 0.096 |
10723 | SLC12A7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.42e-03 | 2.37e-01 | 0.0338 |
10723 | SLC12A7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.43e-05 | 2.77e-01 | 0.0674 |
10723 | SLC12A7 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.29e-02 | 3.08e-01 | 0.0112 |
10723 | SLC12A7 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.01e-08 | 4.60e-01 | 0.0588 |
10723 | SLC12A7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.51e-06 | 3.96e-01 | 0.294 |
10723 | SLC12A7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.67e-34 | 9.71e-01 | 0.3859 |
10723 | SLC12A7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.29e-03 | 4.73e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:0008361 | Colorectum | AD | regulation of cell size | 56/3918 | 181/18723 | 9.61e-04 | 9.07e-03 | 56 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:00325351 | Colorectum | SER | regulation of cellular component size | 115/2897 | 383/18723 | 3.04e-13 | 1.10e-10 | 115 |
GO:00550671 | Colorectum | SER | monovalent inorganic cation homeostasis | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:00325352 | Colorectum | MSS | regulation of cellular component size | 127/3467 | 383/18723 | 3.44e-12 | 5.79e-10 | 127 |
GO:00083611 | Colorectum | MSS | regulation of cell size | 50/3467 | 181/18723 | 1.65e-03 | 1.49e-02 | 50 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:00325357 | Lung | IAC | regulation of cellular component size | 65/2061 | 383/18723 | 2.56e-04 | 4.26e-03 | 65 |
GO:00083615 | Lung | IAC | regulation of cell size | 33/2061 | 181/18723 | 2.47e-03 | 2.33e-02 | 33 |
GO:003253519 | Oral cavity | OSCC | regulation of cellular component size | 201/7305 | 383/18723 | 4.80e-08 | 8.88e-07 | 201 |
GO:00083618 | Oral cavity | OSCC | regulation of cell size | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:003253523 | Oral cavity | EOLP | regulation of cellular component size | 83/2218 | 383/18723 | 2.73e-08 | 1.12e-06 | 83 |
GO:000836113 | Oral cavity | EOLP | regulation of cell size | 35/2218 | 181/18723 | 2.30e-03 | 1.42e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC12A7 | deletion | Frame_Shift_Del | rs767964038 | c.2056delN | p.His686ThrfsTer11 | p.H686Tfs*11 | Q9Y666 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SLC12A7 | deletion | Frame_Shift_Del | rs767964038 | c.2056delN | p.His686ThrfsTer11 | p.H686Tfs*11 | Q9Y666 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC12A7 | SNV | Missense_Mutation | novel | c.171N>T | p.Glu57Asp | p.E57D | Q9Y666 | protein_coding | tolerated(0.86) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC12A7 | SNV | Missense_Mutation | rs771447442 | c.2446N>T | p.Arg816Cys | p.R816C | Q9Y666 | protein_coding | deleterious(0) | benign(0.097) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC12A7 | SNV | Missense_Mutation | rs374815673 | c.938N>A | p.Arg313His | p.R313H | Q9Y666 | protein_coding | deleterious(0.01) | possibly_damaging(0.781) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC12A7 | SNV | Missense_Mutation | rs746991958 | c.1108G>A | p.Ala370Thr | p.A370T | Q9Y666 | protein_coding | tolerated(0.05) | benign(0.007) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC12A7 | SNV | Missense_Mutation | rs140769727 | c.350G>A | p.Arg117His | p.R117H | Q9Y666 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC12A7 | SNV | Missense_Mutation | rs150458053 | c.2623C>T | p.Arg875Trp | p.R875W | Q9Y666 | protein_coding | deleterious(0) | possibly_damaging(0.586) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC12A7 | SNV | Missense_Mutation | novel | c.1913N>T | p.Ala638Val | p.A638V | Q9Y666 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
SLC12A7 | SNV | Missense_Mutation | rs777593952 | c.2875N>A | p.Ala959Thr | p.A959T | Q9Y666 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10723 | SLC12A7 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 178101310 |
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