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Gene: SH3TC1 |
Gene summary for SH3TC1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SH3TC1 | Gene ID | 54436 |
| Gene name | SH3 domain and tetratricopeptide repeats 1 | |
| Gene Alias | SH3TC1 | |
| Cytomap | 4p16.1 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B3KWX8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54436 | SH3TC1 | HCC1_Meng | Human | Liver | HCC | 9.58e-28 | 1.05e-01 | 0.0246 |
| 54436 | SH3TC1 | HCC2_Meng | Human | Liver | HCC | 1.70e-02 | 4.55e-02 | 0.0107 |
| 54436 | SH3TC1 | HCC2 | Human | Liver | HCC | 3.06e-02 | 2.52e+00 | 0.5341 |
| 54436 | SH3TC1 | S014 | Human | Liver | HCC | 9.24e-04 | 2.46e-01 | 0.2254 |
| 54436 | SH3TC1 | S015 | Human | Liver | HCC | 8.85e-13 | 5.33e-01 | 0.2375 |
| 54436 | SH3TC1 | S016 | Human | Liver | HCC | 3.30e-11 | 3.83e-01 | 0.2243 |
| 54436 | SH3TC1 | S027 | Human | Liver | HCC | 2.09e-02 | 3.83e-01 | 0.2446 |
| 54436 | SH3TC1 | S028 | Human | Liver | HCC | 1.59e-11 | 4.64e-01 | 0.2503 |
| 54436 | SH3TC1 | S029 | Human | Liver | HCC | 5.16e-15 | 6.89e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SH3TC1 | SNV | Missense_Mutation | rs778847433 | c.2287N>A | p.Ala763Thr | p.A763T | Q8TE82 | protein_coding | tolerated(0.64) | benign(0.108) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SH3TC1 | SNV | Missense_Mutation | c.2329N>T | p.Thr777Ser | p.T777S | Q8TE82 | protein_coding | tolerated(0.77) | benign(0.072) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SH3TC1 | SNV | Missense_Mutation | c.220C>G | p.Pro74Ala | p.P74A | Q8TE82 | protein_coding | tolerated(0.4) | benign(0.115) | TCGA-DC-6682-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| SH3TC1 | SNV | Missense_Mutation | rs201427300 | c.3940C>T | p.Arg1314Cys | p.R1314C | Q8TE82 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| SH3TC1 | SNV | Missense_Mutation | rs777423178 | c.2972G>A | p.Arg991Gln | p.R991Q | Q8TE82 | protein_coding | tolerated(0.59) | benign(0.024) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SH3TC1 | SNV | Missense_Mutation | novel | c.1835N>A | p.Arg612Gln | p.R612Q | Q8TE82 | protein_coding | deleterious(0) | benign(0.403) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SH3TC1 | SNV | Missense_Mutation | rs150702535 | c.3956N>A | p.Pro1319His | p.P1319H | Q8TE82 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SH3TC1 | SNV | Missense_Mutation | rs756479726 | c.2411C>T | p.Pro804Leu | p.P804L | Q8TE82 | protein_coding | tolerated(0.06) | benign(0.094) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
| SH3TC1 | SNV | Missense_Mutation | c.3164N>A | p.Arg1055Gln | p.R1055Q | Q8TE82 | protein_coding | tolerated(0.09) | benign(0.03) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SH3TC1 | SNV | Missense_Mutation | rs370557515 | c.1646N>T | p.Ala549Val | p.A549V | Q8TE82 | protein_coding | tolerated(0.63) | benign(0.005) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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