![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SH3BP5L |
Gene summary for SH3BP5L |
![]() |
Gene information | Species | Human | Gene symbol | SH3BP5L | Gene ID | 80851 |
Gene name | SH3 binding domain protein 5 like | |
Gene Alias | SH3BP5L | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q7L8J4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80851 | SH3BP5L | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.17e-03 | 2.35e-01 | -0.1808 |
80851 | SH3BP5L | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.01e-03 | 2.30e-01 | -0.0811 |
80851 | SH3BP5L | HTA11_347_2000001011 | Human | Colorectum | AD | 1.90e-05 | 2.17e-01 | -0.1954 |
80851 | SH3BP5L | HTA11_411_2000001011 | Human | Colorectum | SER | 1.69e-03 | 5.74e-01 | -0.2602 |
80851 | SH3BP5L | HTA11_696_2000001011 | Human | Colorectum | AD | 4.74e-09 | 2.98e-01 | -0.1464 |
80851 | SH3BP5L | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.07e-08 | 3.69e-01 | -0.059 |
80851 | SH3BP5L | HTA11_866_3004761011 | Human | Colorectum | AD | 4.20e-08 | 2.94e-01 | 0.096 |
80851 | SH3BP5L | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.28e-03 | 1.67e-01 | 0.0674 |
80851 | SH3BP5L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.18e-08 | 2.79e-01 | 0.3859 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0001933 | Colorectum | AD | negative regulation of protein phosphorylation | 101/3918 | 342/18723 | 9.39e-05 | 1.42e-03 | 101 |
GO:0006469 | Colorectum | AD | negative regulation of protein kinase activity | 65/3918 | 212/18723 | 5.21e-04 | 5.62e-03 | 65 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0061099 | Colorectum | AD | negative regulation of protein tyrosine kinase activity | 13/3918 | 31/18723 | 6.53e-03 | 4.06e-02 | 13 |
GO:00513481 | Colorectum | SER | negative regulation of transferase activity | 70/2897 | 268/18723 | 4.27e-06 | 1.62e-04 | 70 |
GO:00105631 | Colorectum | SER | negative regulation of phosphorus metabolic process | 101/2897 | 442/18723 | 2.39e-05 | 6.70e-04 | 101 |
GO:00459361 | Colorectum | SER | negative regulation of phosphate metabolic process | 100/2897 | 441/18723 | 3.62e-05 | 9.39e-04 | 100 |
GO:00019331 | Colorectum | SER | negative regulation of protein phosphorylation | 79/2897 | 342/18723 | 1.21e-04 | 2.49e-03 | 79 |
GO:00423261 | Colorectum | SER | negative regulation of phosphorylation | 86/2897 | 385/18723 | 2.10e-04 | 3.78e-03 | 86 |
GO:00336731 | Colorectum | SER | negative regulation of kinase activity | 57/2897 | 237/18723 | 3.48e-04 | 5.46e-03 | 57 |
GO:00064691 | Colorectum | SER | negative regulation of protein kinase activity | 52/2897 | 212/18723 | 3.75e-04 | 5.74e-03 | 52 |
GO:00513482 | Colorectum | MSS | negative regulation of transferase activity | 80/3467 | 268/18723 | 4.06e-06 | 1.17e-04 | 80 |
GO:00105632 | Colorectum | MSS | negative regulation of phosphorus metabolic process | 118/3467 | 442/18723 | 1.18e-05 | 2.77e-04 | 118 |
GO:00459362 | Colorectum | MSS | negative regulation of phosphate metabolic process | 117/3467 | 441/18723 | 1.74e-05 | 3.84e-04 | 117 |
GO:00423262 | Colorectum | MSS | negative regulation of phosphorylation | 103/3467 | 385/18723 | 3.76e-05 | 7.17e-04 | 103 |
GO:00019332 | Colorectum | MSS | negative regulation of protein phosphorylation | 93/3467 | 342/18723 | 4.54e-05 | 8.35e-04 | 93 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3BP5L | SNV | Missense_Mutation | novel | c.659N>T | p.Gly220Val | p.G220V | Q7L8J4 | protein_coding | tolerated(0.9) | benign(0.003) | TCGA-55-8204-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SH3BP5L | SNV | Missense_Mutation | c.832N>T | p.Gly278Cys | p.G278C | Q7L8J4 | protein_coding | deleterious(0.03) | probably_damaging(0.954) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
SH3BP5L | SNV | Missense_Mutation | c.367N>C | p.Ala123Pro | p.A123P | Q7L8J4 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
SH3BP5L | SNV | Missense_Mutation | c.225N>G | p.Asn75Lys | p.N75K | Q7L8J4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SH3BP5L | SNV | Missense_Mutation | novel | c.1085G>T | p.Ser362Ile | p.S362I | Q7L8J4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
SH3BP5L | SNV | Missense_Mutation | novel | c.451G>T | p.Val151Leu | p.V151L | Q7L8J4 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SH3BP5L | SNV | Missense_Mutation | c.967G>T | p.Gly323Trp | p.G323W | Q7L8J4 | protein_coding | tolerated(0.07) | benign(0) | TCGA-39-5027-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SH3BP5L | SNV | Missense_Mutation | rs773137834 | c.121N>G | p.Ser41Gly | p.S41G | Q7L8J4 | protein_coding | tolerated_low_confidence(0.42) | benign(0.017) | TCGA-85-7698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
SH3BP5L | SNV | Missense_Mutation | novel | c.22N>T | p.Pro8Ser | p.P8S | Q7L8J4 | protein_coding | tolerated_low_confidence(0.24) | benign(0.007) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
SH3BP5L | SNV | Missense_Mutation | novel | c.361N>G | p.Arg121Gly | p.R121G | Q7L8J4 | protein_coding | tolerated(0.1) | possibly_damaging(0.9) | TCGA-94-7557-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |