GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:003134623 | Thyroid | ATC | positive regulation of cell projection organization | 186/6293 | 353/18723 | 7.99e-14 | 4.23e-12 | 186 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:003253526 | Thyroid | ATC | regulation of cellular component size | 191/6293 | 383/18723 | 2.51e-11 | 8.69e-10 | 191 |
GO:000166731 | Thyroid | ATC | ameboidal-type cell migration | 228/6293 | 475/18723 | 3.72e-11 | 1.22e-09 | 228 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
GO:001097523 | Thyroid | ATC | regulation of neuron projection development | 212/6293 | 445/18723 | 4.16e-10 | 1.14e-08 | 212 |
GO:000164932 | Thyroid | ATC | osteoblast differentiation | 122/6293 | 229/18723 | 6.04e-10 | 1.60e-08 | 122 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:001072022 | Thyroid | ATC | positive regulation of cell development | 146/6293 | 298/18723 | 2.36e-08 | 4.56e-07 | 146 |
GO:000722919 | Thyroid | ATC | integrin-mediated signaling pathway | 63/6293 | 107/18723 | 7.09e-08 | 1.24e-06 | 63 |
GO:004867522 | Thyroid | ATC | axon extension | 68/6293 | 120/18723 | 1.73e-07 | 2.75e-06 | 68 |
GO:005076922 | Thyroid | ATC | positive regulation of neurogenesis | 112/6293 | 225/18723 | 3.53e-07 | 5.21e-06 | 112 |
GO:005076723 | Thyroid | ATC | regulation of neurogenesis | 168/6293 | 364/18723 | 3.73e-07 | 5.48e-06 | 168 |
GO:004876221 | Thyroid | ATC | mesenchymal cell differentiation | 116/6293 | 236/18723 | 5.08e-07 | 7.30e-06 | 116 |
GO:004577314 | Thyroid | ATC | positive regulation of axon extension | 30/6293 | 42/18723 | 6.06e-07 | 8.44e-06 | 30 |
GO:199013824 | Thyroid | ATC | neuron projection extension | 89/6293 | 172/18723 | 6.63e-07 | 9.13e-06 | 89 |
GO:005077213 | Thyroid | ATC | positive regulation of axonogenesis | 48/6293 | 79/18723 | 6.89e-07 | 9.35e-06 | 48 |
GO:004858823 | Thyroid | ATC | developmental cell growth | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEMA7A | SNV | Missense_Mutation | rs760533520 | c.1082C>T | p.Pro361Leu | p.P361L | O75326 | protein_coding | tolerated(0.3) | possibly_damaging(0.853) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEMA7A | SNV | Missense_Mutation | novel | c.1901N>A | p.Gly634Asp | p.G634D | O75326 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA7A | SNV | Missense_Mutation | novel | c.575N>T | p.Arg192Leu | p.R192L | O75326 | protein_coding | tolerated(0.07) | possibly_damaging(0.751) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA7A | SNV | Missense_Mutation | rs200895370 | c.442N>T | p.Arg148Trp | p.R148W | O75326 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-EY-A72D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA7A | SNV | Missense_Mutation | novel | c.1235N>T | p.Ala412Val | p.A412V | O75326 | protein_coding | tolerated(0.28) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SEMA7A | deletion | Frame_Shift_Del | novel | c.405delN | p.Arg135SerfsTer22 | p.R135Sfs*22 | O75326 | protein_coding | | | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA7A | SNV | Missense_Mutation | rs753166445 | c.604N>T | p.Arg202Trp | p.R202W | O75326 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BC-A10Y-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SEMA7A | SNV | Missense_Mutation | rs140707085 | c.709N>A | p.Asp237Asn | p.D237N | O75326 | protein_coding | tolerated(1) | benign(0.006) | TCGA-DD-A39X-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SEMA7A | SNV | Missense_Mutation | novel | c.1709N>T | p.Ser570Phe | p.S570F | O75326 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-AAEB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEMA7A | SNV | Missense_Mutation | | c.1136A>T | p.Gln379Leu | p.Q379L | O75326 | protein_coding | deleterious(0.01) | possibly_damaging(0.619) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |