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Gene: SCP2 |
Gene summary for SCP2 |
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Gene information | Species | Human | Gene symbol | SCP2 | Gene ID | 6342 |
Gene name | sterol carrier protein 2 | |
Gene Alias | NLTP | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | P22307 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6342 | SCP2 | GSM4909281 | Human | Breast | IDC | 5.06e-12 | 4.13e-01 | 0.21 |
6342 | SCP2 | GSM4909282 | Human | Breast | IDC | 9.20e-06 | 3.16e-01 | -0.0288 |
6342 | SCP2 | GSM4909285 | Human | Breast | IDC | 4.32e-22 | 4.07e-01 | 0.21 |
6342 | SCP2 | GSM4909289 | Human | Breast | IDC | 2.25e-04 | 5.15e-01 | 0.1064 |
6342 | SCP2 | GSM4909290 | Human | Breast | IDC | 1.18e-19 | 5.91e-01 | 0.2096 |
6342 | SCP2 | GSM4909294 | Human | Breast | IDC | 2.44e-07 | 2.84e-01 | 0.2022 |
6342 | SCP2 | GSM4909296 | Human | Breast | IDC | 1.01e-06 | -2.15e-01 | 0.1524 |
6342 | SCP2 | GSM4909297 | Human | Breast | IDC | 3.67e-06 | 3.24e-02 | 0.1517 |
6342 | SCP2 | GSM4909298 | Human | Breast | IDC | 6.55e-16 | 3.94e-01 | 0.1551 |
6342 | SCP2 | GSM4909303 | Human | Breast | IDC | 1.20e-02 | 3.89e-01 | 0.0438 |
6342 | SCP2 | GSM4909304 | Human | Breast | IDC | 2.25e-08 | 3.13e-01 | 0.1636 |
6342 | SCP2 | GSM4909306 | Human | Breast | IDC | 7.49e-03 | 2.38e-01 | 0.1564 |
6342 | SCP2 | GSM4909308 | Human | Breast | IDC | 4.81e-05 | 2.63e-01 | 0.158 |
6342 | SCP2 | GSM4909311 | Human | Breast | IDC | 1.27e-20 | -2.17e-01 | 0.1534 |
6342 | SCP2 | GSM4909312 | Human | Breast | IDC | 5.54e-08 | 1.18e-01 | 0.1552 |
6342 | SCP2 | GSM4909316 | Human | Breast | IDC | 4.71e-07 | 4.69e-01 | 0.21 |
6342 | SCP2 | GSM4909319 | Human | Breast | IDC | 3.12e-23 | -2.82e-01 | 0.1563 |
6342 | SCP2 | GSM4909320 | Human | Breast | IDC | 1.36e-03 | -2.73e-01 | 0.1575 |
6342 | SCP2 | GSM4909321 | Human | Breast | IDC | 1.38e-06 | -9.89e-02 | 0.1559 |
6342 | SCP2 | brca2 | Human | Breast | Precancer | 5.94e-04 | 2.07e-01 | -0.024 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00463946 | Breast | Precancer | carboxylic acid biosynthetic process | 32/1080 | 314/18723 | 1.30e-03 | 1.38e-02 | 32 |
GO:00723304 | Breast | Precancer | monocarboxylic acid biosynthetic process | 24/1080 | 214/18723 | 1.41e-03 | 1.48e-02 | 24 |
GO:00160536 | Breast | Precancer | organic acid biosynthetic process | 32/1080 | 316/18723 | 1.44e-03 | 1.50e-02 | 32 |
GO:00066944 | Breast | IDC | steroid biosynthetic process | 25/1434 | 173/18723 | 1.56e-03 | 1.56e-02 | 25 |
GO:007233012 | Breast | IDC | monocarboxylic acid biosynthetic process | 29/1434 | 214/18723 | 1.91e-03 | 1.83e-02 | 29 |
GO:001605313 | Breast | IDC | organic acid biosynthetic process | 39/1434 | 316/18723 | 2.13e-03 | 1.99e-02 | 39 |
GO:004639413 | Breast | IDC | carboxylic acid biosynthetic process | 38/1434 | 314/18723 | 3.39e-03 | 2.83e-02 | 38 |
GO:00323888 | Breast | IDC | positive regulation of intracellular transport | 26/1434 | 202/18723 | 6.33e-03 | 4.47e-02 | 26 |
GO:001605322 | Breast | DCIS | organic acid biosynthetic process | 38/1390 | 316/18723 | 2.22e-03 | 2.04e-02 | 38 |
GO:007233022 | Breast | DCIS | monocarboxylic acid biosynthetic process | 28/1390 | 214/18723 | 2.43e-03 | 2.18e-02 | 28 |
GO:004639422 | Breast | DCIS | carboxylic acid biosynthetic process | 37/1390 | 314/18723 | 3.56e-03 | 2.92e-02 | 37 |
GO:003238813 | Breast | DCIS | positive regulation of intracellular transport | 26/1390 | 202/18723 | 4.24e-03 | 3.33e-02 | 26 |
GO:000669411 | Breast | DCIS | steroid biosynthetic process | 23/1390 | 173/18723 | 4.63e-03 | 3.52e-02 | 23 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01212 | Colorectum | CRC | Fatty acid metabolism | 14/1091 | 57/8465 | 1.17e-02 | 4.99e-02 | 3.38e-02 | 14 |
hsa012121 | Colorectum | CRC | Fatty acid metabolism | 14/1091 | 57/8465 | 1.17e-02 | 4.99e-02 | 3.38e-02 | 14 |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa033206 | Liver | NAFLD | PPAR signaling pathway | 25/1043 | 75/8465 | 1.61e-06 | 6.62e-05 | 5.33e-05 | 25 |
hsa00120 | Liver | NAFLD | Primary bile acid biosynthesis | 9/1043 | 17/8465 | 6.10e-05 | 1.33e-03 | 1.07e-03 | 9 |
hsa04146 | Liver | NAFLD | Peroxisome | 19/1043 | 82/8465 | 4.37e-03 | 4.10e-02 | 3.30e-02 | 19 |
hsa0332011 | Liver | NAFLD | PPAR signaling pathway | 25/1043 | 75/8465 | 1.61e-06 | 6.62e-05 | 5.33e-05 | 25 |
hsa001201 | Liver | NAFLD | Primary bile acid biosynthesis | 9/1043 | 17/8465 | 6.10e-05 | 1.33e-03 | 1.07e-03 | 9 |
hsa041461 | Liver | NAFLD | Peroxisome | 19/1043 | 82/8465 | 4.37e-03 | 4.10e-02 | 3.30e-02 | 19 |
hsa012122 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa041462 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa0332021 | Liver | Cirrhotic | PPAR signaling pathway | 32/2530 | 75/8465 | 1.24e-02 | 3.92e-02 | 2.42e-02 | 32 |
hsa01040 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012123 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa041463 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa0332031 | Liver | Cirrhotic | PPAR signaling pathway | 32/2530 | 75/8465 | 1.24e-02 | 3.92e-02 | 2.42e-02 | 32 |
hsa010401 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCP2 | SNV | Missense_Mutation | c.675N>G | p.Cys225Trp | p.C225W | P22307 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-G3-AAV5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Chemotherapy | hec.1 | SD | |
SCP2 | deletion | Frame_Shift_Del | novel | c.1377_1387delNNNNNNNNNNN | p.Ala460GlufsTer7 | p.A460Efs*7 | P22307 | protein_coding | TCGA-DD-AACG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SCP2 | deletion | Frame_Shift_Del | novel | c.683delN | p.Ser228Ter | p.S228* | P22307 | protein_coding | TCGA-WX-AA44-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Targeted Molecular therapy | sorafenib | PR | ||
SCP2 | SNV | Missense_Mutation | c.407G>A | p.Arg136Lys | p.R136K | P22307 | protein_coding | deleterious(0.04) | benign(0.247) | TCGA-44-7660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Vaccine | recprame+as15 | PD | |
SCP2 | SNV | Missense_Mutation | c.840N>A | p.Met280Ile | p.M280I | P22307 | protein_coding | deleterious(0.01) | possibly_damaging(0.718) | TCGA-49-4514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCP2 | SNV | Missense_Mutation | c.1159G>T | p.Ala387Ser | p.A387S | P22307 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SCP2 | SNV | Missense_Mutation | c.521N>G | p.Tyr174Cys | p.Y174C | P22307 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
SCP2 | SNV | Missense_Mutation | novel | c.794G>C | p.Ser265Thr | p.S265T | P22307 | protein_coding | deleterious(0.02) | benign(0.022) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SCP2 | SNV | Missense_Mutation | novel | c.932N>T | p.Asn311Ile | p.N311I | P22307 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCP2 | SNV | Missense_Mutation | novel | c.1532N>C | p.Lys511Thr | p.K511T | P22307 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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