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Gene: SCCPDH |
Gene summary for SCCPDH |
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Gene information | Species | Human | Gene symbol | SCCPDH | Gene ID | 51097 |
Gene name | saccharopine dehydrogenase (putative) | |
Gene Alias | CGI-49 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q8NBX0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51097 | SCCPDH | GSM4909282 | Human | Breast | IDC | 2.85e-30 | 6.44e-01 | -0.0288 |
51097 | SCCPDH | GSM4909293 | Human | Breast | IDC | 1.44e-11 | 3.12e-01 | 0.1581 |
51097 | SCCPDH | GSM4909296 | Human | Breast | IDC | 1.47e-04 | -1.97e-01 | 0.1524 |
51097 | SCCPDH | GSM4909298 | Human | Breast | IDC | 3.88e-03 | 1.44e-01 | 0.1551 |
51097 | SCCPDH | GSM4909308 | Human | Breast | IDC | 7.72e-10 | 4.31e-01 | 0.158 |
51097 | SCCPDH | GSM4909311 | Human | Breast | IDC | 5.07e-08 | -1.40e-01 | 0.1534 |
51097 | SCCPDH | GSM4909312 | Human | Breast | IDC | 1.15e-02 | 1.33e-01 | 0.1552 |
51097 | SCCPDH | GSM4909315 | Human | Breast | IDC | 6.74e-04 | -2.69e-01 | 0.21 |
51097 | SCCPDH | GSM4909319 | Human | Breast | IDC | 4.99e-13 | -2.14e-01 | 0.1563 |
51097 | SCCPDH | brca2 | Human | Breast | Precancer | 1.61e-13 | 5.17e-01 | -0.024 |
51097 | SCCPDH | brca3 | Human | Breast | Precancer | 1.42e-06 | 2.55e-01 | -0.0263 |
51097 | SCCPDH | M2 | Human | Breast | IDC | 3.38e-02 | 4.64e-01 | 0.21 |
51097 | SCCPDH | NCCBC14 | Human | Breast | DCIS | 1.24e-06 | 3.63e-01 | 0.2021 |
51097 | SCCPDH | NCCBC5 | Human | Breast | DCIS | 6.01e-05 | -1.92e-01 | 0.2046 |
51097 | SCCPDH | P1 | Human | Breast | IDC | 9.84e-05 | -2.79e-02 | 0.1527 |
51097 | SCCPDH | DCIS2 | Human | Breast | DCIS | 2.03e-16 | -1.89e-01 | 0.0085 |
51097 | SCCPDH | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.47e-05 | 3.97e-01 | -0.0811 |
51097 | SCCPDH | HTA11_78_2000001011 | Human | Colorectum | AD | 4.33e-04 | 4.21e-01 | -0.1088 |
51097 | SCCPDH | HTA11_347_2000001011 | Human | Colorectum | AD | 6.57e-08 | 3.93e-01 | -0.1954 |
51097 | SCCPDH | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.05e-02 | 3.01e-01 | -0.059 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00464673 | Esophagus | ESCC | membrane lipid biosynthetic process | 91/8552 | 142/18723 | 7.19e-06 | 7.19e-05 | 91 |
GO:00066642 | Esophagus | ESCC | glycolipid metabolic process | 63/8552 | 100/18723 | 3.55e-04 | 2.06e-03 | 63 |
GO:19035092 | Esophagus | ESCC | liposaccharide metabolic process | 63/8552 | 101/18723 | 5.25e-04 | 2.90e-03 | 63 |
GO:0009247 | Esophagus | ESCC | glycolipid biosynthetic process | 42/8552 | 68/18723 | 5.48e-03 | 2.05e-02 | 42 |
GO:0006643 | Liver | Cirrhotic | membrane lipid metabolic process | 69/4634 | 203/18723 | 1.89e-03 | 1.19e-02 | 69 |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:0046467 | Liver | HCC | membrane lipid biosynthetic process | 78/7958 | 142/18723 | 1.85e-03 | 9.46e-03 | 78 |
GO:0006664 | Liver | HCC | glycolipid metabolic process | 57/7958 | 100/18723 | 2.40e-03 | 1.17e-02 | 57 |
GO:1903509 | Liver | HCC | liposaccharide metabolic process | 57/7958 | 101/18723 | 3.25e-03 | 1.49e-02 | 57 |
GO:00066432 | Oral cavity | OSCC | membrane lipid metabolic process | 111/7305 | 203/18723 | 4.02e-06 | 4.69e-05 | 111 |
GO:00464672 | Oral cavity | OSCC | membrane lipid biosynthetic process | 77/7305 | 142/18723 | 1.63e-04 | 1.13e-03 | 77 |
GO:00066641 | Oral cavity | OSCC | glycolipid metabolic process | 53/7305 | 100/18723 | 3.09e-03 | 1.33e-02 | 53 |
GO:19035091 | Oral cavity | OSCC | liposaccharide metabolic process | 53/7305 | 101/18723 | 4.06e-03 | 1.66e-02 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCCPDH | SNV | Missense_Mutation | c.928N>T | p.Ile310Leu | p.I310L | Q8NBX0 | protein_coding | tolerated(1) | benign(0.011) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
SCCPDH | SNV | Missense_Mutation | novel | c.197C>A | p.Pro66Gln | p.P66Q | Q8NBX0 | protein_coding | tolerated(0.19) | benign(0.17) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCCPDH | SNV | Missense_Mutation | c.739C>G | p.Pro247Ala | p.P247A | Q8NBX0 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD | |
SCCPDH | SNV | Missense_Mutation | c.994G>A | p.Asp332Asn | p.D332N | Q8NBX0 | protein_coding | tolerated(0.12) | possibly_damaging(0.544) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
SCCPDH | SNV | Missense_Mutation | c.512A>G | p.Asn171Ser | p.N171S | Q8NBX0 | protein_coding | tolerated(0.41) | benign(0.005) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCCPDH | SNV | Missense_Mutation | c.869N>A | p.Met290Lys | p.M290K | Q8NBX0 | protein_coding | deleterious(0.03) | possibly_damaging(0.664) | TCGA-33-4547-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SCCPDH | SNV | Missense_Mutation | c.1142N>A | p.Ala381Glu | p.A381E | Q8NBX0 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SCCPDH | SNV | Missense_Mutation | novel | c.802N>C | p.Glu268Gln | p.E268Q | Q8NBX0 | protein_coding | tolerated(0.69) | benign(0.034) | TCGA-58-8393-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCCPDH | SNV | Missense_Mutation | novel | c.864N>C | p.Lys288Asn | p.K288N | Q8NBX0 | protein_coding | tolerated(0.31) | probably_damaging(0.984) | TCGA-85-8354-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SCCPDH | SNV | Missense_Mutation | novel | c.364G>T | p.Asp122Tyr | p.D122Y | Q8NBX0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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