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Gene: SARS2 |
Gene summary for SARS2 |
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Gene information | Species | Human | Gene symbol | SARS2 | Gene ID | 54938 |
Gene name | seryl-tRNA synthetase 2, mitochondrial | |
Gene Alias | SARS | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | Q9NP81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54938 | SARS2 | LZE7T | Human | Esophagus | ESCC | 1.35e-05 | 2.87e-01 | 0.0667 |
54938 | SARS2 | LZE8T | Human | Esophagus | ESCC | 2.38e-04 | 2.08e-01 | 0.067 |
54938 | SARS2 | LZE24T | Human | Esophagus | ESCC | 1.38e-02 | 1.21e-01 | 0.0596 |
54938 | SARS2 | LZE6T | Human | Esophagus | ESCC | 2.12e-04 | 1.74e-01 | 0.0845 |
54938 | SARS2 | P1T-E | Human | Esophagus | ESCC | 2.24e-10 | 4.49e-01 | 0.0875 |
54938 | SARS2 | P2T-E | Human | Esophagus | ESCC | 1.38e-12 | 2.83e-01 | 0.1177 |
54938 | SARS2 | P4T-E | Human | Esophagus | ESCC | 8.28e-20 | 4.12e-01 | 0.1323 |
54938 | SARS2 | P5T-E | Human | Esophagus | ESCC | 7.71e-11 | 2.44e-01 | 0.1327 |
54938 | SARS2 | P8T-E | Human | Esophagus | ESCC | 1.97e-20 | 3.66e-01 | 0.0889 |
54938 | SARS2 | P9T-E | Human | Esophagus | ESCC | 2.93e-02 | 1.01e-01 | 0.1131 |
54938 | SARS2 | P10T-E | Human | Esophagus | ESCC | 1.17e-24 | 4.91e-01 | 0.116 |
54938 | SARS2 | P11T-E | Human | Esophagus | ESCC | 1.55e-11 | 4.52e-01 | 0.1426 |
54938 | SARS2 | P12T-E | Human | Esophagus | ESCC | 8.41e-21 | 4.34e-01 | 0.1122 |
54938 | SARS2 | P15T-E | Human | Esophagus | ESCC | 5.99e-16 | 3.32e-01 | 0.1149 |
54938 | SARS2 | P16T-E | Human | Esophagus | ESCC | 5.45e-16 | 3.41e-01 | 0.1153 |
54938 | SARS2 | P17T-E | Human | Esophagus | ESCC | 1.38e-04 | 2.86e-01 | 0.1278 |
54938 | SARS2 | P19T-E | Human | Esophagus | ESCC | 3.24e-08 | 4.49e-01 | 0.1662 |
54938 | SARS2 | P20T-E | Human | Esophagus | ESCC | 2.08e-11 | 2.83e-01 | 0.1124 |
54938 | SARS2 | P21T-E | Human | Esophagus | ESCC | 6.89e-06 | 1.91e-01 | 0.1617 |
54938 | SARS2 | P22T-E | Human | Esophagus | ESCC | 7.94e-16 | 2.88e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0000959 | Liver | HCC | mitochondrial RNA metabolic process | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00009591 | Oral cavity | OSCC | mitochondrial RNA metabolic process | 29/7305 | 49/18723 | 3.33e-03 | 1.42e-02 | 29 |
GO:003466011 | Oral cavity | LP | ncRNA metabolic process | 205/4623 | 485/18723 | 6.46e-18 | 1.09e-15 | 205 |
GO:003254313 | Oral cavity | LP | mitochondrial translation | 43/4623 | 76/18723 | 2.85e-09 | 1.26e-07 | 43 |
GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SARS2 | SNV | Missense_Mutation | c.977N>T | p.Cys326Phe | p.C326F | Q9NP81 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-DD-A1EI-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SARS2 | SNV | Missense_Mutation | c.44G>A | p.Arg15His | p.R15H | Q9NP81 | protein_coding | tolerated_low_confidence(0.26) | benign(0) | TCGA-DD-A4NI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SARS2 | SNV | Missense_Mutation | c.1268N>C | p.Ser423Thr | p.S423T | Q9NP81 | protein_coding | deleterious(0.02) | benign(0.187) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SARS2 | SNV | Missense_Mutation | c.170N>C | p.Gln57Pro | p.Q57P | Q9NP81 | protein_coding | deleterious(0.05) | benign(0.039) | TCGA-62-A46S-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | tarceva | PD | |
SARS2 | SNV | Missense_Mutation | rs754330537 | c.1137N>T | p.Glu379Asp | p.E379D | Q9NP81 | protein_coding | tolerated(0.16) | benign(0.116) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SARS2 | SNV | Missense_Mutation | c.1111G>C | p.Glu371Gln | p.E371Q | Q9NP81 | protein_coding | tolerated(0.25) | benign(0.014) | TCGA-97-A4M5-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SARS2 | SNV | Missense_Mutation | rs780828600 | c.875N>A | p.Arg292His | p.R292H | Q9NP81 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-33-4532-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SARS2 | SNV | Missense_Mutation | novel | c.1153N>T | p.Gly385Cys | p.G385C | Q9NP81 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SARS2 | SNV | Missense_Mutation | novel | c.407N>T | p.Pro136Leu | p.P136L | Q9NP81 | protein_coding | tolerated(0.14) | possibly_damaging(0.729) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SARS2 | SNV | Missense_Mutation | novel | c.406N>T | p.Pro136Ser | p.P136S | Q9NP81 | protein_coding | tolerated(0.23) | benign(0.342) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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