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Gene: RSBN1L |
Gene summary for RSBN1L |
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Gene information | Species | Human | Gene symbol | RSBN1L | Gene ID | 222194 |
Gene name | round spermatid basic protein 1 like | |
Gene Alias | RSBN1L | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6PCB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222194 | RSBN1L | LZE2D | Human | Esophagus | HGIN | 1.28e-02 | 2.34e-01 | 0.0642 |
222194 | RSBN1L | LZE2T | Human | Esophagus | ESCC | 3.77e-05 | 6.56e-01 | 0.082 |
222194 | RSBN1L | LZE3D | Human | Esophagus | HGIN | 8.67e-04 | 8.71e-01 | 0.0668 |
222194 | RSBN1L | LZE4T | Human | Esophagus | ESCC | 2.29e-16 | 4.82e-01 | 0.0811 |
222194 | RSBN1L | LZE7T | Human | Esophagus | ESCC | 7.55e-17 | 9.59e-01 | 0.0667 |
222194 | RSBN1L | LZE8T | Human | Esophagus | ESCC | 9.21e-04 | 2.53e-01 | 0.067 |
222194 | RSBN1L | LZE20T | Human | Esophagus | ESCC | 1.53e-14 | 3.86e-01 | 0.0662 |
222194 | RSBN1L | LZE22D1 | Human | Esophagus | HGIN | 1.01e-10 | 4.21e-01 | 0.0595 |
222194 | RSBN1L | LZE22T | Human | Esophagus | ESCC | 2.45e-10 | 6.75e-01 | 0.068 |
222194 | RSBN1L | LZE24T | Human | Esophagus | ESCC | 5.64e-21 | 5.75e-01 | 0.0596 |
222194 | RSBN1L | LZE22D3 | Human | Esophagus | HGIN | 3.47e-04 | 5.17e-01 | 0.0653 |
222194 | RSBN1L | LZE21T | Human | Esophagus | ESCC | 2.86e-11 | 6.24e-01 | 0.0655 |
222194 | RSBN1L | LZE6T | Human | Esophagus | ESCC | 2.37e-08 | 2.52e-01 | 0.0845 |
222194 | RSBN1L | P1T-E | Human | Esophagus | ESCC | 1.15e-22 | 1.13e+00 | 0.0875 |
222194 | RSBN1L | P2T-E | Human | Esophagus | ESCC | 1.13e-51 | 9.26e-01 | 0.1177 |
222194 | RSBN1L | P4T-E | Human | Esophagus | ESCC | 1.96e-41 | 1.01e+00 | 0.1323 |
222194 | RSBN1L | P5T-E | Human | Esophagus | ESCC | 1.14e-33 | 5.66e-01 | 0.1327 |
222194 | RSBN1L | P8T-E | Human | Esophagus | ESCC | 1.25e-35 | 7.34e-01 | 0.0889 |
222194 | RSBN1L | P9T-E | Human | Esophagus | ESCC | 8.18e-39 | 9.43e-01 | 0.1131 |
222194 | RSBN1L | P10T-E | Human | Esophagus | ESCC | 6.77e-67 | 1.16e+00 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSBN1L | SNV | Missense_Mutation | rs199556120 | c.1529N>A | p.Arg510Gln | p.R510Q | Q6PCB5 | protein_coding | tolerated(0.11) | probably_damaging(0.987) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RSBN1L | SNV | Missense_Mutation | novel | c.1306G>T | p.Asp436Tyr | p.D436Y | Q6PCB5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RSBN1L | SNV | Missense_Mutation | novel | c.1518A>C | p.Lys506Asn | p.K506N | Q6PCB5 | protein_coding | tolerated(0.12) | benign(0.219) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RSBN1L | deletion | Frame_Shift_Del | c.1646delA | p.Asn549IlefsTer27 | p.N549Ifs*27 | Q6PCB5 | protein_coding | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RSBN1L | SNV | Missense_Mutation | rs202084915 | c.1294N>G | p.Leu432Val | p.L432V | Q6PCB5 | protein_coding | deleterious(0.02) | possibly_damaging(0.607) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
RSBN1L | SNV | Missense_Mutation | rs202084915 | c.1294N>G | p.Leu432Val | p.L432V | Q6PCB5 | protein_coding | deleterious(0.02) | possibly_damaging(0.607) | TCGA-A5-A0VO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSBN1L | SNV | Missense_Mutation | rs202084915 | c.1294N>G | p.Leu432Val | p.L432V | Q6PCB5 | protein_coding | deleterious(0.02) | possibly_damaging(0.607) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
RSBN1L | SNV | Missense_Mutation | novel | c.1063C>T | p.Pro355Ser | p.P355S | Q6PCB5 | protein_coding | tolerated(0.12) | possibly_damaging(0.674) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSBN1L | SNV | Missense_Mutation | novel | c.765A>C | p.Lys255Asn | p.K255N | Q6PCB5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RSBN1L | SNV | Missense_Mutation | rs199556120 | c.1529N>A | p.Arg510Gln | p.R510Q | Q6PCB5 | protein_coding | tolerated(0.11) | probably_damaging(0.987) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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