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Gene: RRP9 |
Gene summary for RRP9 |
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Gene information | Species | Human | Gene symbol | RRP9 | Gene ID | 9136 |
Gene name | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein | |
Gene Alias | RNU3IP2 | |
Cytomap | 3p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O43818 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9136 | RRP9 | LZE24T | Human | Esophagus | ESCC | 3.31e-08 | 2.06e-01 | 0.0596 |
9136 | RRP9 | LZE21T | Human | Esophagus | ESCC | 2.52e-03 | 1.38e-01 | 0.0655 |
9136 | RRP9 | P1T-E | Human | Esophagus | ESCC | 1.23e-02 | 1.30e-01 | 0.0875 |
9136 | RRP9 | P2T-E | Human | Esophagus | ESCC | 2.14e-10 | 1.50e-01 | 0.1177 |
9136 | RRP9 | P4T-E | Human | Esophagus | ESCC | 9.88e-13 | 3.78e-01 | 0.1323 |
9136 | RRP9 | P5T-E | Human | Esophagus | ESCC | 3.81e-07 | 2.27e-01 | 0.1327 |
9136 | RRP9 | P8T-E | Human | Esophagus | ESCC | 4.32e-15 | 8.67e-02 | 0.0889 |
9136 | RRP9 | P9T-E | Human | Esophagus | ESCC | 6.85e-11 | 2.22e-01 | 0.1131 |
9136 | RRP9 | P10T-E | Human | Esophagus | ESCC | 1.31e-20 | 3.97e-01 | 0.116 |
9136 | RRP9 | P11T-E | Human | Esophagus | ESCC | 3.23e-11 | 3.73e-01 | 0.1426 |
9136 | RRP9 | P12T-E | Human | Esophagus | ESCC | 1.00e-14 | 3.08e-01 | 0.1122 |
9136 | RRP9 | P15T-E | Human | Esophagus | ESCC | 4.22e-15 | 1.87e-01 | 0.1149 |
9136 | RRP9 | P16T-E | Human | Esophagus | ESCC | 6.17e-13 | 2.82e-01 | 0.1153 |
9136 | RRP9 | P17T-E | Human | Esophagus | ESCC | 6.08e-04 | 1.92e-01 | 0.1278 |
9136 | RRP9 | P19T-E | Human | Esophagus | ESCC | 6.88e-07 | 6.29e-01 | 0.1662 |
9136 | RRP9 | P20T-E | Human | Esophagus | ESCC | 2.07e-14 | 2.87e-01 | 0.1124 |
9136 | RRP9 | P21T-E | Human | Esophagus | ESCC | 6.89e-31 | 6.18e-01 | 0.1617 |
9136 | RRP9 | P22T-E | Human | Esophagus | ESCC | 2.87e-15 | 3.11e-01 | 0.1236 |
9136 | RRP9 | P23T-E | Human | Esophagus | ESCC | 3.92e-23 | 5.39e-01 | 0.108 |
9136 | RRP9 | P24T-E | Human | Esophagus | ESCC | 5.76e-12 | 3.19e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRP9 | SNV | Missense_Mutation | c.1106N>C | p.Gly369Ala | p.G369A | O43818 | protein_coding | tolerated(0.18) | benign(0.057) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | rs750834054 | c.499N>A | p.Asp167Asn | p.D167N | O43818 | protein_coding | deleterious(0.03) | probably_damaging(0.958) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD |
RRP9 | SNV | Missense_Mutation | c.239T>A | p.Leu80Gln | p.L80Q | O43818 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | novel | c.179N>T | p.Pro60Leu | p.P60L | O43818 | protein_coding | tolerated(0.37) | benign(0) | TCGA-37-A5EN-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
RRP9 | SNV | Missense_Mutation | c.721C>T | p.Arg241Trp | p.R241W | O43818 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | c.1229G>A | p.Arg410Gln | p.R410Q | O43818 | protein_coding | deleterious(0.04) | benign(0.08) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | c.604N>A | p.Val202Ile | p.V202I | O43818 | protein_coding | tolerated(0.78) | benign(0.017) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | novel | c.995N>C | p.Leu332Pro | p.L332P | O43818 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
RRP9 | SNV | Missense_Mutation | c.841N>A | p.Gly281Arg | p.G281R | O43818 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BJ-A18Y-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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