![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RNF39 |
Gene summary for RNF39 |
![]() |
Gene information | Species | Human | Gene symbol | RNF39 | Gene ID | 80352 |
Gene name | ring finger protein 39 | |
Gene Alias | FAP216 | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q96QB5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80352 | RNF39 | LZE4T | Human | Esophagus | ESCC | 4.17e-02 | 2.25e-02 | 0.0811 |
80352 | RNF39 | LZE8T | Human | Esophagus | ESCC | 2.42e-05 | 1.12e-01 | 0.067 |
80352 | RNF39 | LZE24T | Human | Esophagus | ESCC | 1.17e-21 | 9.49e-01 | 0.0596 |
80352 | RNF39 | P1T-E | Human | Esophagus | ESCC | 9.17e-22 | 1.63e+00 | 0.0875 |
80352 | RNF39 | P2T-E | Human | Esophagus | ESCC | 4.65e-10 | 9.46e-02 | 0.1177 |
80352 | RNF39 | P4T-E | Human | Esophagus | ESCC | 2.17e-05 | 2.07e-01 | 0.1323 |
80352 | RNF39 | P8T-E | Human | Esophagus | ESCC | 6.28e-22 | 8.22e-01 | 0.0889 |
80352 | RNF39 | P10T-E | Human | Esophagus | ESCC | 1.70e-06 | 9.95e-02 | 0.116 |
80352 | RNF39 | P16T-E | Human | Esophagus | ESCC | 3.87e-03 | 8.50e-02 | 0.1153 |
80352 | RNF39 | P22T-E | Human | Esophagus | ESCC | 1.20e-02 | 1.40e-01 | 0.1236 |
80352 | RNF39 | P23T-E | Human | Esophagus | ESCC | 3.82e-15 | 9.86e-01 | 0.108 |
80352 | RNF39 | P26T-E | Human | Esophagus | ESCC | 2.39e-09 | 3.65e-01 | 0.1276 |
80352 | RNF39 | P27T-E | Human | Esophagus | ESCC | 2.78e-12 | 5.87e-01 | 0.1055 |
80352 | RNF39 | P30T-E | Human | Esophagus | ESCC | 4.49e-08 | 3.95e-01 | 0.137 |
80352 | RNF39 | P39T-E | Human | Esophagus | ESCC | 2.78e-07 | 6.01e-01 | 0.0894 |
80352 | RNF39 | P42T-E | Human | Esophagus | ESCC | 6.48e-07 | 3.63e-01 | 0.1175 |
80352 | RNF39 | P47T-E | Human | Esophagus | ESCC | 9.72e-08 | 4.91e-01 | 0.1067 |
80352 | RNF39 | P48T-E | Human | Esophagus | ESCC | 1.34e-08 | 3.54e-01 | 0.0959 |
80352 | RNF39 | P52T-E | Human | Esophagus | ESCC | 2.85e-03 | 1.47e-03 | 0.1555 |
80352 | RNF39 | P54T-E | Human | Esophagus | ESCC | 1.69e-13 | 7.09e-01 | 0.0975 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF39 | SNV | Missense_Mutation | c.17T>C | p.Leu6Ser | p.L6S | Q9H2S5 | protein_coding | tolerated_low_confidence(0.26) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF39 | SNV | Missense_Mutation | novel | c.1087N>T | p.Arg363Trp | p.R363W | Q9H2S5 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
RNF39 | deletion | Frame_Shift_Del | c.664delA | p.Met222CysfsTer5 | p.M222Cfs*5 | Q9H2S5 | protein_coding | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |||
RNF39 | deletion | Frame_Shift_Del | c.664delN | p.Met222CysfsTer5 | p.M222Cfs*5 | Q9H2S5 | protein_coding | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD | |||
RNF39 | SNV | Missense_Mutation | c.46N>A | p.Glu16Lys | p.E16K | Q9H2S5 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-EM-A3AQ-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |