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Gene: RNF26 |
Gene summary for RNF26 |
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Gene information | Species | Human | Gene symbol | RNF26 | Gene ID | 79102 |
Gene name | ring finger protein 26 | |
Gene Alias | RNF26 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9BY78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79102 | RNF26 | LZE4T | Human | Esophagus | ESCC | 4.10e-05 | 9.86e-02 | 0.0811 |
79102 | RNF26 | LZE8T | Human | Esophagus | ESCC | 1.35e-07 | 1.46e-01 | 0.067 |
79102 | RNF26 | LZE20T | Human | Esophagus | ESCC | 1.94e-02 | 1.86e-01 | 0.0662 |
79102 | RNF26 | LZE22D1 | Human | Esophagus | HGIN | 8.19e-03 | 1.68e-01 | 0.0595 |
79102 | RNF26 | LZE22T | Human | Esophagus | ESCC | 4.56e-13 | 1.23e+00 | 0.068 |
79102 | RNF26 | LZE24T | Human | Esophagus | ESCC | 9.63e-19 | 5.12e-01 | 0.0596 |
79102 | RNF26 | P1T-E | Human | Esophagus | ESCC | 1.43e-04 | 1.52e-01 | 0.0875 |
79102 | RNF26 | P2T-E | Human | Esophagus | ESCC | 4.77e-13 | 2.94e-01 | 0.1177 |
79102 | RNF26 | P4T-E | Human | Esophagus | ESCC | 2.40e-22 | 6.49e-01 | 0.1323 |
79102 | RNF26 | P5T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.55e-01 | 0.1327 |
79102 | RNF26 | P9T-E | Human | Esophagus | ESCC | 7.20e-10 | 2.20e-01 | 0.1131 |
79102 | RNF26 | P10T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.16e-01 | 0.116 |
79102 | RNF26 | P11T-E | Human | Esophagus | ESCC | 3.93e-15 | 4.94e-01 | 0.1426 |
79102 | RNF26 | P12T-E | Human | Esophagus | ESCC | 2.13e-27 | 4.47e-01 | 0.1122 |
79102 | RNF26 | P15T-E | Human | Esophagus | ESCC | 3.50e-08 | 2.62e-01 | 0.1149 |
79102 | RNF26 | P16T-E | Human | Esophagus | ESCC | 6.48e-20 | 3.18e-01 | 0.1153 |
79102 | RNF26 | P17T-E | Human | Esophagus | ESCC | 3.52e-05 | 3.11e-01 | 0.1278 |
79102 | RNF26 | P19T-E | Human | Esophagus | ESCC | 7.97e-05 | 4.30e-01 | 0.1662 |
79102 | RNF26 | P20T-E | Human | Esophagus | ESCC | 1.07e-18 | 1.51e-01 | 0.1124 |
79102 | RNF26 | P21T-E | Human | Esophagus | ESCC | 3.41e-36 | 6.76e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000020916 | Esophagus | HGIN | protein polyubiquitination | 58/2587 | 236/18723 | 6.29e-06 | 1.97e-04 | 58 |
GO:00070328 | Esophagus | HGIN | endosome organization | 25/2587 | 82/18723 | 7.45e-05 | 1.69e-03 | 25 |
GO:00160509 | Esophagus | HGIN | vesicle organization | 65/2587 | 300/18723 | 1.24e-04 | 2.54e-03 | 65 |
GO:00709794 | Esophagus | HGIN | protein K11-linked ubiquitination | 11/2587 | 29/18723 | 1.08e-03 | 1.32e-02 | 11 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:00324794 | Esophagus | HGIN | regulation of type I interferon production | 23/2587 | 95/18723 | 4.51e-03 | 3.93e-02 | 23 |
GO:00326064 | Esophagus | HGIN | type I interferon production | 23/2587 | 95/18723 | 4.51e-03 | 3.93e-02 | 23 |
GO:00028325 | Esophagus | HGIN | negative regulation of response to biotic stimulus | 25/2587 | 108/18723 | 5.87e-03 | 4.77e-02 | 25 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:007097912 | Esophagus | ESCC | protein K11-linked ubiquitination | 27/8552 | 29/18723 | 8.09e-08 | 1.39e-06 | 27 |
GO:000703214 | Esophagus | ESCC | endosome organization | 61/8552 | 82/18723 | 1.13e-07 | 1.85e-06 | 61 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
GO:003247912 | Esophagus | ESCC | regulation of type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:003260612 | Esophagus | ESCC | type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF26 | SNV | Missense_Mutation | c.322N>C | p.Ala108Pro | p.A108P | Q9BY78 | protein_coding | tolerated(0.06) | benign(0.005) | TCGA-66-2782-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unspecific | PD | ||
RNF26 | SNV | Missense_Mutation | c.1168G>T | p.Val390Leu | p.V390L | Q9BY78 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CH-5771-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
RNF26 | SNV | Missense_Mutation | rs773328736 | c.127N>A | p.Val43Ile | p.V43I | Q9BY78 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF26 | SNV | Missense_Mutation | c.208N>A | p.Glu70Lys | p.E70K | Q9BY78 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RNF26 | SNV | Missense_Mutation | rs144743618 | c.908N>A | p.Arg303Gln | p.R303Q | Q9BY78 | protein_coding | tolerated(0.21) | benign(0.007) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RNF26 | SNV | Missense_Mutation | rs150700766 | c.1045N>T | p.Pro349Ser | p.P349S | Q9BY78 | protein_coding | tolerated(0.32) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RNF26 | SNV | Missense_Mutation | rs779473222 | c.1256C>T | p.Pro419Leu | p.P419L | Q9BY78 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RNF26 | SNV | Missense_Mutation | rs150176910 | c.835N>T | p.Arg279Cys | p.R279C | Q9BY78 | protein_coding | tolerated(0.08) | benign(0.306) | TCGA-HF-7136-01 | Stomach | stomach adenocarcinoma | Male | Unknown | III/IV | Unspecific | Cepecitabine | SD |
RNF26 | SNV | Missense_Mutation | rs777702624 | c.1237G>A | p.Val413Ile | p.V413I | Q9BY78 | protein_coding | tolerated(1) | benign(0) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
RNF26 | SNV | Missense_Mutation | novel | c.1281G>T | p.Gln427His | p.Q427H | Q9BY78 | protein_coding | deleterious(0.03) | benign(0.171) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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