GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
GO:0042176113 | Thyroid | PTC | regulation of protein catabolic process | 231/5968 | 391/18723 | 4.76e-29 | 2.14e-26 | 231 |
GO:1903362113 | Thyroid | PTC | regulation of cellular protein catabolic process | 162/5968 | 255/18723 | 1.62e-25 | 5.12e-23 | 162 |
GO:1903050113 | Thyroid | PTC | regulation of proteolysis involved in cellular protein catabolic process | 140/5968 | 221/18723 | 4.63e-22 | 1.01e-19 | 140 |
GO:0045732113 | Thyroid | PTC | positive regulation of protein catabolic process | 142/5968 | 231/18723 | 1.43e-20 | 2.38e-18 | 142 |
GO:2000058113 | Thyroid | PTC | regulation of ubiquitin-dependent protein catabolic process | 110/5968 | 164/18723 | 1.83e-20 | 2.97e-18 | 110 |
GO:0061136113 | Thyroid | PTC | regulation of proteasomal protein catabolic process | 121/5968 | 187/18723 | 2.25e-20 | 3.37e-18 | 121 |
GO:0032434113 | Thyroid | PTC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 94/5968 | 134/18723 | 9.17e-20 | 1.23e-17 | 94 |
GO:1903364113 | Thyroid | PTC | positive regulation of cellular protein catabolic process | 104/5968 | 155/18723 | 1.93e-19 | 2.39e-17 | 104 |
GO:0045862113 | Thyroid | PTC | positive regulation of proteolysis | 198/5968 | 372/18723 | 6.68e-18 | 6.91e-16 | 198 |
GO:1901800112 | Thyroid | PTC | positive regulation of proteasomal protein catabolic process | 80/5968 | 114/18723 | 4.80e-17 | 4.27e-15 | 80 |
GO:1903052112 | Thyroid | PTC | positive regulation of proteolysis involved in cellular protein catabolic process | 88/5968 | 133/18723 | 4.30e-16 | 3.39e-14 | 88 |
GO:0032436113 | Thyroid | PTC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 66/5968 | 90/18723 | 7.51e-16 | 5.64e-14 | 66 |
GO:2000060113 | Thyroid | PTC | positive regulation of ubiquitin-dependent protein catabolic process | 73/5968 | 107/18723 | 1.19e-14 | 7.75e-13 | 73 |
GO:000020920 | Thyroid | PTC | protein polyubiquitination | 128/5968 | 236/18723 | 7.81e-13 | 3.65e-11 | 128 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF144A | SNV | Missense_Mutation | | c.47N>T | p.Pro16Leu | p.P16L | P50876 | protein_coding | deleterious(0.03) | probably_damaging(0.988) | TCGA-34-5236-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RNF144A | SNV | Missense_Mutation | | c.112T>C | p.Cys38Arg | p.C38R | P50876 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-43-3394-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | PD |
RNF144A | SNV | Missense_Mutation | novel | c.20G>T | p.Arg7Leu | p.R7L | P50876 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.953) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RNF144A | SNV | Missense_Mutation | | c.666C>G | p.Phe222Leu | p.F222L | P50876 | protein_coding | tolerated(0.06) | probably_damaging(0.95) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RNF144A | SNV | Missense_Mutation | novel | c.532N>C | p.Asp178His | p.D178H | P50876 | protein_coding | deleterious(0.05) | benign(0.287) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
RNF144A | SNV | Missense_Mutation | | c.179N>T | p.Glu60Val | p.E60V | P50876 | protein_coding | tolerated(0.63) | benign(0.261) | TCGA-66-2786-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF144A | SNV | Missense_Mutation | novel | c.457N>A | p.Gly153Ser | p.G153S | P50876 | protein_coding | tolerated(0.24) | benign(0.259) | TCGA-85-7698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
RNF144A | SNV | Missense_Mutation | novel | c.458N>T | p.Gly153Val | p.G153V | P50876 | protein_coding | tolerated(0.07) | benign(0.053) | TCGA-85-7698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
RNF144A | SNV | Missense_Mutation | novel | c.532N>T | p.Asp178Tyr | p.D178Y | P50876 | protein_coding | deleterious(0) | benign(0.358) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
RNF144A | SNV | Missense_Mutation | novel | c.134N>G | p.Leu45Arg | p.L45R | P50876 | protein_coding | tolerated(0.5) | possibly_damaging(0.526) | TCGA-ZG-A9M4-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |