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Gene: RMND5A |
Gene summary for RMND5A |
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Gene information | Species | Human | Gene symbol | RMND5A | Gene ID | 64795 |
Gene name | required for meiotic nuclear division 5 homolog A | |
Gene Alias | CTLH | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9H871 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64795 | RMND5A | LZE4T | Human | Esophagus | ESCC | 1.38e-02 | -2.94e-02 | 0.0811 |
64795 | RMND5A | LZE22T | Human | Esophagus | ESCC | 2.09e-02 | 2.28e-01 | 0.068 |
64795 | RMND5A | LZE24T | Human | Esophagus | ESCC | 5.06e-07 | 1.88e-01 | 0.0596 |
64795 | RMND5A | P1T-E | Human | Esophagus | ESCC | 8.08e-04 | 2.71e-01 | 0.0875 |
64795 | RMND5A | P2T-E | Human | Esophagus | ESCC | 4.10e-36 | 7.35e-01 | 0.1177 |
64795 | RMND5A | P4T-E | Human | Esophagus | ESCC | 1.31e-28 | 6.81e-01 | 0.1323 |
64795 | RMND5A | P5T-E | Human | Esophagus | ESCC | 7.71e-18 | 3.29e-01 | 0.1327 |
64795 | RMND5A | P8T-E | Human | Esophagus | ESCC | 1.98e-14 | 9.22e-02 | 0.0889 |
64795 | RMND5A | P9T-E | Human | Esophagus | ESCC | 9.25e-07 | 1.05e-01 | 0.1131 |
64795 | RMND5A | P10T-E | Human | Esophagus | ESCC | 2.12e-26 | 5.98e-01 | 0.116 |
64795 | RMND5A | P11T-E | Human | Esophagus | ESCC | 6.29e-04 | 3.20e-02 | 0.1426 |
64795 | RMND5A | P12T-E | Human | Esophagus | ESCC | 1.82e-11 | 2.66e-01 | 0.1122 |
64795 | RMND5A | P15T-E | Human | Esophagus | ESCC | 1.67e-15 | 3.56e-01 | 0.1149 |
64795 | RMND5A | P16T-E | Human | Esophagus | ESCC | 1.10e-14 | 2.16e-01 | 0.1153 |
64795 | RMND5A | P20T-E | Human | Esophagus | ESCC | 4.24e-10 | 2.08e-01 | 0.1124 |
64795 | RMND5A | P21T-E | Human | Esophagus | ESCC | 1.21e-08 | 3.44e-02 | 0.1617 |
64795 | RMND5A | P22T-E | Human | Esophagus | ESCC | 6.95e-19 | 1.49e-01 | 0.1236 |
64795 | RMND5A | P23T-E | Human | Esophagus | ESCC | 8.31e-13 | 4.11e-01 | 0.108 |
64795 | RMND5A | P24T-E | Human | Esophagus | ESCC | 1.38e-10 | 1.82e-02 | 0.1287 |
64795 | RMND5A | P26T-E | Human | Esophagus | ESCC | 2.72e-22 | 4.33e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:000020911 | Liver | Cirrhotic | protein polyubiquitination | 89/4634 | 236/18723 | 6.09e-06 | 9.80e-05 | 89 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:001049820 | Oral cavity | OSCC | proteasomal protein catabolic process | 336/7305 | 490/18723 | 5.45e-41 | 8.63e-38 | 336 |
GO:004316120 | Oral cavity | OSCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 285/7305 | 412/18723 | 5.68e-36 | 5.99e-33 | 285 |
GO:000020910 | Oral cavity | OSCC | protein polyubiquitination | 150/7305 | 236/18723 | 1.59e-14 | 9.27e-13 | 150 |
GO:0010498110 | Oral cavity | LP | proteasomal protein catabolic process | 224/4623 | 490/18723 | 9.57e-25 | 4.00e-22 | 224 |
GO:0043161110 | Oral cavity | LP | proteasome-mediated ubiquitin-dependent protein catabolic process | 190/4623 | 412/18723 | 1.08e-21 | 2.93e-19 | 190 |
GO:000020915 | Oral cavity | LP | protein polyubiquitination | 82/4623 | 236/18723 | 3.23e-04 | 3.26e-03 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RMND5A | SNV | Missense_Mutation | novel | c.214N>C | p.Val72Leu | p.V72L | Q9H871 | protein_coding | tolerated(0.24) | benign(0.047) | TCGA-L9-A443-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RMND5A | SNV | Missense_Mutation | rs199760511 | c.232N>A | p.Asp78Asn | p.D78N | Q9H871 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
RMND5A | SNV | Missense_Mutation | novel | c.973N>T | p.Gly325Cys | p.G325C | Q9H871 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-O1-A52J-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RMND5A | SNV | Missense_Mutation | c.25N>T | p.Arg9Cys | p.R9C | Q9H871 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
RMND5A | SNV | Missense_Mutation | novel | c.194N>C | p.Cys65Ser | p.C65S | Q9H871 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-60-2696-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RMND5A | SNV | Missense_Mutation | novel | c.50N>T | p.Lys17Met | p.K17M | Q9H871 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-CV-5443-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
RMND5A | SNV | Missense_Mutation | c.1126T>C | p.Tyr376His | p.Y376H | Q9H871 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RMND5A | SNV | Missense_Mutation | c.586N>G | p.Arg196Gly | p.R196G | Q9H871 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RMND5A | SNV | Missense_Mutation | novel | c.695N>C | p.Gln232Pro | p.Q232P | Q9H871 | protein_coding | tolerated(0.06) | benign(0.171) | TCGA-IN-A7NU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | taxol | PD |
RMND5A | insertion | Frame_Shift_Ins | novel | c.496_497insTAAT | p.Arg167IlefsTer28 | p.R167Ifs*28 | Q9H871 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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