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Gene: RIN1 |
Gene summary for RIN1 |
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Gene information | Species | Human | Gene symbol | RIN1 | Gene ID | 9610 |
Gene name | Ras and Rab interactor 1 | |
Gene Alias | RIN1 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A0S2Z4U0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9610 | RIN1 | P2T-E | Human | Esophagus | ESCC | 5.72e-05 | 6.96e-02 | 0.1177 |
9610 | RIN1 | P4T-E | Human | Esophagus | ESCC | 1.34e-05 | 2.19e-01 | 0.1323 |
9610 | RIN1 | P5T-E | Human | Esophagus | ESCC | 9.64e-13 | 2.60e-01 | 0.1327 |
9610 | RIN1 | P8T-E | Human | Esophagus | ESCC | 1.34e-04 | 7.71e-02 | 0.0889 |
9610 | RIN1 | P11T-E | Human | Esophagus | ESCC | 3.46e-07 | 5.08e-01 | 0.1426 |
9610 | RIN1 | P15T-E | Human | Esophagus | ESCC | 6.52e-06 | 2.51e-01 | 0.1149 |
9610 | RIN1 | P16T-E | Human | Esophagus | ESCC | 2.01e-12 | 1.62e-01 | 0.1153 |
9610 | RIN1 | P17T-E | Human | Esophagus | ESCC | 5.49e-10 | 5.31e-01 | 0.1278 |
9610 | RIN1 | P20T-E | Human | Esophagus | ESCC | 4.34e-12 | 3.10e-01 | 0.1124 |
9610 | RIN1 | P21T-E | Human | Esophagus | ESCC | 1.52e-25 | 5.19e-01 | 0.1617 |
9610 | RIN1 | P22T-E | Human | Esophagus | ESCC | 1.59e-11 | 1.28e-01 | 0.1236 |
9610 | RIN1 | P23T-E | Human | Esophagus | ESCC | 6.60e-08 | 2.23e-01 | 0.108 |
9610 | RIN1 | P24T-E | Human | Esophagus | ESCC | 3.05e-12 | 2.07e-01 | 0.1287 |
9610 | RIN1 | P26T-E | Human | Esophagus | ESCC | 1.80e-10 | 2.27e-01 | 0.1276 |
9610 | RIN1 | P27T-E | Human | Esophagus | ESCC | 9.03e-14 | 1.74e-01 | 0.1055 |
9610 | RIN1 | P28T-E | Human | Esophagus | ESCC | 1.09e-05 | 1.59e-01 | 0.1149 |
9610 | RIN1 | P31T-E | Human | Esophagus | ESCC | 2.22e-08 | 1.56e-01 | 0.1251 |
9610 | RIN1 | P32T-E | Human | Esophagus | ESCC | 2.88e-14 | 2.84e-01 | 0.1666 |
9610 | RIN1 | P36T-E | Human | Esophagus | ESCC | 1.82e-08 | 2.11e-01 | 0.1187 |
9610 | RIN1 | P37T-E | Human | Esophagus | ESCC | 1.84e-21 | 5.52e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:2000116 | Colorectum | AD | regulation of cysteine-type endopeptidase activity | 79/3918 | 235/18723 | 3.74e-06 | 1.03e-04 | 79 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0052548 | Colorectum | AD | regulation of endopeptidase activity | 124/3918 | 432/18723 | 6.58e-05 | 1.07e-03 | 124 |
GO:0010950 | Colorectum | AD | positive regulation of endopeptidase activity | 59/3918 | 179/18723 | 1.11e-04 | 1.65e-03 | 59 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:2000379 | Colorectum | AD | positive regulation of reactive oxygen species metabolic process | 29/3918 | 76/18723 | 4.31e-04 | 4.82e-03 | 29 |
GO:2001056 | Colorectum | AD | positive regulation of cysteine-type endopeptidase activity | 47/3918 | 148/18723 | 1.30e-03 | 1.14e-02 | 47 |
GO:2000377 | Colorectum | AD | regulation of reactive oxygen species metabolic process | 48/3918 | 157/18723 | 2.77e-03 | 2.09e-02 | 48 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:01060272 | Colorectum | MSS | neuron projection organization | 34/3467 | 93/18723 | 3.04e-05 | 6.14e-04 | 34 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00107692 | Colorectum | MSS | regulation of cell morphogenesis involved in differentiation | 34/3467 | 96/18723 | 6.43e-05 | 1.12e-03 | 34 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00107702 | Colorectum | MSS | positive regulation of cell morphogenesis involved in differentiation | 29/3467 | 79/18723 | 1.04e-04 | 1.63e-03 | 29 |
GO:00107202 | Colorectum | MSS | positive regulation of cell development | 81/3467 | 298/18723 | 1.38e-04 | 2.06e-03 | 81 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIN1 | SNV | Missense_Mutation | rs748150722 | c.745N>A | p.Val249Met | p.V249M | Q13671 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-38-4632-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | gemcitabine | PD |
RIN1 | SNV | Missense_Mutation | rs3181770 | c.2255C>T | p.Ser752Phe | p.S752F | Q13671 | protein_coding | tolerated_low_confidence(0.05) | benign(0.205) | TCGA-44-6776-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIN1 | SNV | Missense_Mutation | c.397N>T | p.Gly133Cys | p.G133C | Q13671 | protein_coding | deleterious(0) | possibly_damaging(0.831) | TCGA-97-7553-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RIN1 | SNV | Missense_Mutation | novel | c.1345N>T | p.Ala449Ser | p.A449S | Q13671 | protein_coding | tolerated(0.72) | benign(0.005) | TCGA-97-8179-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RIN1 | SNV | Missense_Mutation | c.830N>T | p.Gln277Leu | p.Q277L | Q13671 | protein_coding | tolerated(0.12) | benign(0.014) | TCGA-MP-A4TC-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
RIN1 | SNV | Missense_Mutation | novel | c.796N>G | p.Pro266Ala | p.P266A | Q13671 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-77-7338-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RIN1 | SNV | Missense_Mutation | novel | c.694N>A | p.Asp232Asn | p.D232N | Q13671 | protein_coding | tolerated(0.25) | probably_damaging(0.992) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RIN1 | SNV | Missense_Mutation | novel | c.656N>C | p.Gly219Ala | p.G219A | Q13671 | protein_coding | tolerated(0.06) | benign(0.121) | TCGA-LA-A7SW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
RIN1 | SNV | Missense_Mutation | novel | c.555N>C | p.Trp185Cys | p.W185C | Q13671 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-LA-A7SW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
RIN1 | SNV | Missense_Mutation | novel | c.428N>T | p.Gln143Leu | p.Q143L | Q13671 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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