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Gene: RIC8B |
Gene summary for RIC8B |
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Gene information | Species | Human | Gene symbol | RIC8B | Gene ID | 55188 |
Gene name | RIC8 guanine nucleotide exchange factor B | |
Gene Alias | RIC8 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | B7WPL0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55188 | RIC8B | NAFLD1 | Human | Liver | NAFLD | 8.72e-03 | 3.25e-01 | -0.04 |
55188 | RIC8B | S43 | Human | Liver | Cirrhotic | 5.64e-05 | -1.68e-01 | -0.0187 |
55188 | RIC8B | HCC1_Meng | Human | Liver | HCC | 1.41e-37 | -8.79e-02 | 0.0246 |
55188 | RIC8B | HCC2_Meng | Human | Liver | HCC | 1.24e-06 | -1.35e-01 | 0.0107 |
55188 | RIC8B | cirrhotic2 | Human | Liver | Cirrhotic | 1.88e-04 | 2.38e-01 | 0.0201 |
55188 | RIC8B | HCC1 | Human | Liver | HCC | 8.86e-04 | 5.84e-01 | 0.5336 |
55188 | RIC8B | S027 | Human | Liver | HCC | 4.00e-03 | 5.42e-01 | 0.2446 |
55188 | RIC8B | S028 | Human | Liver | HCC | 9.32e-03 | 1.99e-01 | 0.2503 |
55188 | RIC8B | S029 | Human | Liver | HCC | 5.00e-05 | 3.46e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIC8B | SNV | Missense_Mutation | novel | c.1085N>T | p.Gly362Val | p.G362V | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-G3-A25S-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sunitinib | PD | |
RIC8B | SNV | Missense_Mutation | c.461N>T | p.Arg154Leu | p.R154L | protein_coding | tolerated(0.3) | benign(0.143) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | ||
RIC8B | SNV | Missense_Mutation | c.1027C>T | p.His343Tyr | p.H343Y | protein_coding | deleterious(0.03) | benign(0.097) | TCGA-62-A471-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
RIC8B | SNV | Missense_Mutation | c.1420N>C | p.Asp474His | p.D474H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | ||
RIC8B | SNV | Missense_Mutation | c.1660N>C | p.Glu554Gln | p.E554Q | protein_coding | tolerated(1) | benign(0.001) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD | ||
RIC8B | SNV | Missense_Mutation | novel | c.214N>T | p.Ile72Phe | p.I72F | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
RIC8B | SNV | Missense_Mutation | c.1060G>C | p.Asp354His | p.D354H | protein_coding | tolerated(0.19) | probably_damaging(1) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
RIC8B | SNV | Missense_Mutation | novel | c.907N>C | p.Glu303Gln | p.E303Q | protein_coding | tolerated(0.26) | benign(0.224) | TCGA-CQ-5334-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RIC8B | SNV | Missense_Mutation | novel | c.1349G>T | p.Gly450Val | p.G450V | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RIC8B | SNV | Missense_Mutation | c.1420G>T | p.Asp474Tyr | p.D474Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D6-6517-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | methotrexate | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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