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Gene: REG1A |
Gene summary for REG1A |
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Gene information | Species | Human | Gene symbol | REG1A | Gene ID | 5967 |
Gene name | regenerating family member 1 alpha | |
Gene Alias | ICRF | |
Cytomap | 2p12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A8K7G6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5967 | REG1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.65e-40 | 2.86e+00 | 0.0155 |
5967 | REG1A | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.19e-26 | 2.79e+00 | 0.0216 |
5967 | REG1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.47e-09 | 1.59e+00 | -0.1207 |
5967 | REG1A | HTA11_696_2000001011 | Human | Colorectum | AD | 2.00e-49 | 3.13e+00 | -0.1464 |
5967 | REG1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.31e-58 | 4.67e+00 | -0.059 |
5967 | REG1A | HTA11_546_2000001011 | Human | Colorectum | AD | 6.13e-20 | 2.21e+00 | -0.0842 |
5967 | REG1A | HTA11_866_3004761011 | Human | Colorectum | AD | 5.47e-53 | 3.67e+00 | 0.096 |
5967 | REG1A | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.10e-09 | 1.51e+00 | 0.0131 |
5967 | REG1A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.40e-35 | 2.37e+00 | 0.0338 |
5967 | REG1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.15e-36 | 1.48e+00 | 0.0674 |
5967 | REG1A | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.16e-02 | 2.25e+00 | 0.0397 |
5967 | REG1A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.53e-38 | 9.14e-01 | 0.294 |
5967 | REG1A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.23e-08 | 1.58e+00 | 0.3487 |
5967 | REG1A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.22e-10 | 1.63e+00 | 0.281 |
5967 | REG1A | A002-C-010 | Human | Colorectum | FAP | 1.40e-04 | 3.22e-01 | 0.242 |
5967 | REG1A | S014 | Human | Liver | HCC | 1.29e-52 | 4.16e+00 | 0.2254 |
5967 | REG1A | S015 | Human | Liver | HCC | 1.17e-21 | 3.11e+00 | 0.2375 |
5967 | REG1A | S016 | Human | Liver | HCC | 8.26e-35 | 1.99e+00 | 0.2243 |
5967 | REG1A | HTA12-15-2 | Human | Pancreas | PDAC | 2.63e-53 | -2.83e+00 | 0.2315 |
5967 | REG1A | HTA12-16-2 | Human | Pancreas | PDAC | 1.98e-12 | -5.92e-01 | 0.0535 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0097421 | Colorectum | AD | liver regeneration | 18/3918 | 35/18723 | 6.33e-05 | 1.05e-03 | 18 |
GO:0030307 | Colorectum | AD | positive regulation of cell growth | 54/3918 | 166/18723 | 3.08e-04 | 3.69e-03 | 54 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0048588 | Colorectum | AD | developmental cell growth | 67/3918 | 234/18723 | 3.03e-03 | 2.25e-02 | 67 |
GO:0048639 | Colorectum | AD | positive regulation of developmental growth | 52/3918 | 174/18723 | 3.24e-03 | 2.38e-02 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REG1A | SNV | Missense_Mutation | rs142176788 | c.88C>T | p.Pro30Ser | p.P30S | P05451 | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-DD-AAVS-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
REG1A | SNV | Missense_Mutation | c.241G>T | p.Gly81Cys | p.G81C | P05451 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-44-6777-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | c.193N>A | p.Gln65Lys | p.Q65K | P05451 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-49-AAR0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | c.272N>T | p.Ser91Ile | p.S91I | P05451 | protein_coding | tolerated(0.16) | possibly_damaging(0.58) | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | c.410N>T | p.Cys137Phe | p.C137F | P05451 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | c.198N>A | p.Asn66Lys | p.N66K | P05451 | protein_coding | tolerated(1) | possibly_damaging(0.491) | TCGA-78-7156-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | c.392N>T | p.Ser131Ile | p.S131I | P05451 | protein_coding | tolerated(0.64) | benign(0.112) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | c.93N>T | p.Gln31His | p.Q31H | P05451 | protein_coding | deleterious(0) | benign(0.027) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
REG1A | SNV | Missense_Mutation | novel | c.451N>T | p.Asp151Tyr | p.D151Y | P05451 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REG1A | SNV | Missense_Mutation | c.116G>A | p.Gly39Asp | p.G39D | P05451 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-97-7554-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5967 | REG1A | DRUGGABLE GENOME, GROWTH FACTOR | LINOMIDE | ROQUINIMEX | 9564847 | |
5967 | REG1A | DRUGGABLE GENOME, GROWTH FACTOR | INSULIN | INSULIN | 9930932 |
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