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Gene: RCBTB1 |
Gene summary for RCBTB1 |
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Gene information | Species | Human | Gene symbol | RCBTB1 | Gene ID | 55213 |
Gene name | RCC1 and BTB domain containing protein 1 | |
Gene Alias | CLLD7 | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | B3KR20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55213 | RCBTB1 | HCC1_Meng | Human | Liver | HCC | 1.37e-20 | 9.72e-03 | 0.0246 |
55213 | RCBTB1 | HCC1 | Human | Liver | HCC | 3.76e-02 | 2.31e+00 | 0.5336 |
55213 | RCBTB1 | HCC2 | Human | Liver | HCC | 5.12e-09 | 2.52e+00 | 0.5341 |
55213 | RCBTB1 | S028 | Human | Liver | HCC | 2.94e-02 | 2.07e-01 | 0.2503 |
55213 | RCBTB1 | S029 | Human | Liver | HCC | 7.00e-04 | 3.13e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCBTB1 | SNV | Missense_Mutation | c.930N>C | p.Trp310Cys | p.W310C | Q8NDN9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-4486-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RCBTB1 | SNV | Missense_Mutation | novel | c.1564N>C | p.Lys522Gln | p.K522Q | Q8NDN9 | protein_coding | deleterious(0.03) | possibly_damaging(0.662) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
RCBTB1 | SNV | Missense_Mutation | c.1349N>T | p.Tyr450Phe | p.Y450F | Q8NDN9 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RCBTB1 | SNV | Missense_Mutation | c.863N>T | p.Glu288Val | p.E288V | Q8NDN9 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RCBTB1 | SNV | Missense_Mutation | novel | c.610N>A | p.Gly204Ser | p.G204S | Q8NDN9 | protein_coding | tolerated(0.52) | possibly_damaging(0.491) | TCGA-37-A5EM-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RCBTB1 | SNV | Missense_Mutation | novel | c.1342A>G | p.Thr448Ala | p.T448A | Q8NDN9 | protein_coding | deleterious(0.05) | benign(0.159) | TCGA-63-A5MW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RCBTB1 | SNV | Missense_Mutation | c.1443N>C | p.Arg481Ser | p.R481S | Q8NDN9 | protein_coding | deleterious(0) | benign(0.146) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
RCBTB1 | SNV | Missense_Mutation | rs754407540 | c.1025N>T | p.Ser342Leu | p.S342L | Q8NDN9 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCBTB1 | SNV | Missense_Mutation | c.74N>A | p.Cys25Tyr | p.C25Y | Q8NDN9 | protein_coding | deleterious(0.04) | benign(0.043) | TCGA-BR-7958-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RCBTB1 | SNV | Missense_Mutation | c.244G>A | p.Gly82Arg | p.G82R | Q8NDN9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8380-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | polyplatillen | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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