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Gene: RASL11A |
Gene summary for RASL11A |
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Gene information | Species | Human | Gene symbol | RASL11A | Gene ID | 387496 |
Gene name | RAS like family 11 member A | |
Gene Alias | RASL11A | |
Cytomap | 13q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6T310 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387496 | RASL11A | LZE8T | Human | Esophagus | ESCC | 4.02e-05 | 1.66e-01 | 0.067 |
387496 | RASL11A | P1T-E | Human | Esophagus | ESCC | 1.64e-05 | 4.55e-01 | 0.0875 |
387496 | RASL11A | P2T-E | Human | Esophagus | ESCC | 3.06e-02 | 9.46e-02 | 0.1177 |
387496 | RASL11A | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.85e-01 | 0.1323 |
387496 | RASL11A | P8T-E | Human | Esophagus | ESCC | 3.29e-20 | 4.42e-01 | 0.0889 |
387496 | RASL11A | P9T-E | Human | Esophagus | ESCC | 5.41e-23 | 7.80e-01 | 0.1131 |
387496 | RASL11A | P10T-E | Human | Esophagus | ESCC | 2.40e-07 | 1.20e-01 | 0.116 |
387496 | RASL11A | P11T-E | Human | Esophagus | ESCC | 1.72e-04 | 2.28e-01 | 0.1426 |
387496 | RASL11A | P12T-E | Human | Esophagus | ESCC | 1.21e-08 | 2.79e-01 | 0.1122 |
387496 | RASL11A | P15T-E | Human | Esophagus | ESCC | 8.38e-13 | 3.02e-01 | 0.1149 |
387496 | RASL11A | P16T-E | Human | Esophagus | ESCC | 1.08e-03 | 7.23e-02 | 0.1153 |
387496 | RASL11A | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.30e-01 | 0.1278 |
387496 | RASL11A | P20T-E | Human | Esophagus | ESCC | 1.51e-02 | 1.29e-01 | 0.1124 |
387496 | RASL11A | P21T-E | Human | Esophagus | ESCC | 1.04e-08 | 7.69e-02 | 0.1617 |
387496 | RASL11A | P23T-E | Human | Esophagus | ESCC | 5.52e-07 | 2.32e-01 | 0.108 |
387496 | RASL11A | P26T-E | Human | Esophagus | ESCC | 9.86e-22 | 6.79e-01 | 0.1276 |
387496 | RASL11A | P27T-E | Human | Esophagus | ESCC | 2.30e-12 | 4.08e-01 | 0.1055 |
387496 | RASL11A | P28T-E | Human | Esophagus | ESCC | 1.38e-19 | 5.44e-01 | 0.1149 |
387496 | RASL11A | P30T-E | Human | Esophagus | ESCC | 5.30e-14 | 4.92e-01 | 0.137 |
387496 | RASL11A | P32T-E | Human | Esophagus | ESCC | 3.37e-02 | 5.92e-02 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00063564 | Esophagus | ESCC | regulation of transcription by RNA polymerase I | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:00459432 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase I | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00063563 | Oral cavity | OSCC | regulation of transcription by RNA polymerase I | 25/7305 | 34/18723 | 4.63e-05 | 3.90e-04 | 25 |
GO:00063601 | Oral cavity | OSCC | transcription by RNA polymerase I | 36/7305 | 55/18723 | 6.42e-05 | 5.22e-04 | 36 |
GO:00459431 | Oral cavity | OSCC | positive regulation of transcription by RNA polymerase I | 18/7305 | 23/18723 | 1.47e-04 | 1.04e-03 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASL11A | SNV | Missense_Mutation | rs767537468 | c.463N>T | p.Arg155Trp | p.R155W | Q6T310 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4191-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | SD |
RASL11A | SNV | Missense_Mutation | c.538N>A | p.Glu180Lys | p.E180K | Q6T310 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BR-8588-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RASL11A | SNV | Missense_Mutation | c.256N>A | p.Val86Ile | p.V86I | Q6T310 | protein_coding | tolerated(0.73) | benign(0.006) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RASL11A | SNV | Missense_Mutation | rs747958383 | c.374N>A | p.Arg125Gln | p.R125Q | Q6T310 | protein_coding | tolerated(0.53) | benign(0.065) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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