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Gene: RASGEF1A |
Gene summary for RASGEF1A |
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Gene information | Species | Human | Gene symbol | RASGEF1A | Gene ID | 221002 |
Gene name | RasGEF domain family member 1A | |
Gene Alias | CG4853 | |
Cytomap | 10q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q8N9B8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221002 | RASGEF1A | P2T-E | Human | Esophagus | ESCC | 1.70e-02 | 1.18e-01 | 0.1177 |
221002 | RASGEF1A | P5T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.31e-01 | 0.1327 |
221002 | RASGEF1A | P11T-E | Human | Esophagus | ESCC | 1.22e-13 | 4.94e-01 | 0.1426 |
221002 | RASGEF1A | P17T-E | Human | Esophagus | ESCC | 3.92e-04 | 2.29e-01 | 0.1278 |
221002 | RASGEF1A | P19T-E | Human | Esophagus | ESCC | 2.17e-08 | 6.40e-01 | 0.1662 |
221002 | RASGEF1A | P24T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.55e-01 | 0.1287 |
221002 | RASGEF1A | P27T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.99e-02 | 0.1055 |
221002 | RASGEF1A | P28T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.31e-01 | 0.1149 |
221002 | RASGEF1A | P36T-E | Human | Esophagus | ESCC | 3.07e-02 | 1.70e-01 | 0.1187 |
221002 | RASGEF1A | P37T-E | Human | Esophagus | ESCC | 4.28e-10 | 1.70e-01 | 0.1371 |
221002 | RASGEF1A | P38T-E | Human | Esophagus | ESCC | 1.85e-04 | 2.26e-01 | 0.127 |
221002 | RASGEF1A | P80T-E | Human | Esophagus | ESCC | 1.51e-08 | 2.31e-01 | 0.155 |
221002 | RASGEF1A | P89T-E | Human | Esophagus | ESCC | 1.07e-13 | 7.81e-01 | 0.1752 |
221002 | RASGEF1A | P107T-E | Human | Esophagus | ESCC | 1.56e-06 | 1.61e-01 | 0.171 |
221002 | RASGEF1A | P128T-E | Human | Esophagus | ESCC | 3.32e-03 | 1.49e-01 | 0.1241 |
221002 | RASGEF1A | P130T-E | Human | Esophagus | ESCC | 6.36e-33 | 6.22e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASGEF1A | SNV | Missense_Mutation | c.1036N>T | p.Ala346Ser | p.A346S | Q8N9B8 | protein_coding | deleterious(0.04) | possibly_damaging(0.525) | TCGA-DD-A73E-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RASGEF1A | SNV | Missense_Mutation | novel | c.1403G>A | p.Gly468Asp | p.G468D | Q8N9B8 | protein_coding | deleterious(0.04) | possibly_damaging(0.563) | TCGA-DD-AAW3-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RASGEF1A | SNV | Missense_Mutation | novel | c.557N>C | p.Gln186Pro | p.Q186P | Q8N9B8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-44-2665-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Targeted Molecular therapy | bevacizumab | SD |
RASGEF1A | SNV | Missense_Mutation | novel | c.1173N>G | p.Asn391Lys | p.N391K | Q8N9B8 | protein_coding | deleterious(0) | benign(0.063) | TCGA-53-A4EZ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
RASGEF1A | SNV | Missense_Mutation | c.106N>A | p.Gly36Arg | p.G36R | Q8N9B8 | protein_coding | tolerated(0.5) | benign(0.007) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RASGEF1A | SNV | Missense_Mutation | c.1381N>A | p.Val461Ile | p.V461I | Q8N9B8 | protein_coding | tolerated(0.2) | benign(0) | TCGA-91-7771-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
RASGEF1A | SNV | Missense_Mutation | c.928N>T | p.Arg310Trp | p.R310W | Q8N9B8 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
RASGEF1A | SNV | Missense_Mutation | c.1381G>A | p.Val461Ile | p.V461I | Q8N9B8 | protein_coding | tolerated(0.2) | benign(0) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RASGEF1A | SNV | Missense_Mutation | novel | c.1453N>G | p.Leu485Val | p.L485V | Q8N9B8 | protein_coding | tolerated(0.18) | benign(0.327) | TCGA-56-7579-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
RASGEF1A | SNV | Missense_Mutation | novel | c.593N>A | p.Ala198Asp | p.A198D | Q8N9B8 | protein_coding | deleterious(0.01) | benign(0.323) | TCGA-58-8386-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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