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Gene: RASAL2 |
Gene summary for RASAL2 |
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Gene information | Species | Human | Gene symbol | RASAL2 | Gene ID | 9462 |
Gene name | RAS protein activator like 2 | |
Gene Alias | NGAP | |
Cytomap | 1q25.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A8K2P3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9462 | RASAL2 | CCI_1 | Human | Cervix | CC | 5.65e-11 | 1.99e+00 | 0.528 |
9462 | RASAL2 | CCI_2 | Human | Cervix | CC | 7.83e-15 | 1.18e+00 | 0.5249 |
9462 | RASAL2 | CCI_3 | Human | Cervix | CC | 1.77e-13 | 1.07e+00 | 0.516 |
9462 | RASAL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.10e-05 | -2.87e-01 | 0.0155 |
9462 | RASAL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.24e-02 | 4.65e-01 | -0.059 |
9462 | RASAL2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.21e-03 | 9.00e-01 | 0.3487 |
9462 | RASAL2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.04e-05 | 6.76e-01 | 0.281 |
9462 | RASAL2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.32e-09 | -4.47e-01 | 0.3005 |
9462 | RASAL2 | A002-C-010 | Human | Colorectum | FAP | 5.17e-03 | 3.11e-01 | 0.242 |
9462 | RASAL2 | A015-C-203 | Human | Colorectum | FAP | 2.92e-21 | -4.04e-01 | -0.1294 |
9462 | RASAL2 | A015-C-204 | Human | Colorectum | FAP | 4.58e-05 | -3.42e-01 | -0.0228 |
9462 | RASAL2 | A014-C-040 | Human | Colorectum | FAP | 1.10e-02 | -3.83e-01 | -0.1184 |
9462 | RASAL2 | A002-C-201 | Human | Colorectum | FAP | 7.54e-09 | -5.88e-02 | 0.0324 |
9462 | RASAL2 | A002-C-203 | Human | Colorectum | FAP | 4.56e-03 | 2.17e-01 | 0.2786 |
9462 | RASAL2 | A001-C-119 | Human | Colorectum | FAP | 4.35e-05 | -3.67e-01 | -0.1557 |
9462 | RASAL2 | A001-C-108 | Human | Colorectum | FAP | 2.66e-10 | -2.56e-01 | -0.0272 |
9462 | RASAL2 | A002-C-205 | Human | Colorectum | FAP | 2.44e-18 | -3.52e-01 | -0.1236 |
9462 | RASAL2 | A001-C-104 | Human | Colorectum | FAP | 3.74e-02 | -1.74e-01 | 0.0184 |
9462 | RASAL2 | A015-C-006 | Human | Colorectum | FAP | 3.82e-14 | -5.32e-01 | -0.0994 |
9462 | RASAL2 | A015-C-106 | Human | Colorectum | FAP | 1.93e-14 | -4.21e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430876 | Lung | IAC | regulation of GTPase activity | 67/2061 | 348/18723 | 3.43e-06 | 1.44e-04 | 67 |
GO:004308711 | Lung | AIS | regulation of GTPase activity | 65/1849 | 348/18723 | 3.35e-07 | 2.83e-05 | 65 |
GO:004308721 | Lung | MIAC | regulation of GTPase activity | 41/967 | 348/18723 | 7.39e-07 | 1.08e-04 | 41 |
GO:00430879 | Prostate | BPH | regulation of GTPase activity | 88/3107 | 348/18723 | 2.04e-05 | 2.49e-04 | 88 |
GO:004308713 | Prostate | Tumor | regulation of GTPase activity | 88/3246 | 348/18723 | 1.04e-04 | 1.00e-03 | 88 |
GO:004308716 | Skin | AK | regulation of GTPase activity | 54/1910 | 348/18723 | 1.17e-03 | 8.98e-03 | 54 |
GO:004308717 | Skin | SCCIS | regulation of GTPase activity | 39/919 | 348/18723 | 1.38e-06 | 8.71e-05 | 39 |
GO:004308718 | Thyroid | PTC | regulation of GTPase activity | 148/5968 | 348/18723 | 1.63e-05 | 1.71e-04 | 148 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa04014 | Colorectum | CRC | Ras signaling pathway | 49/1091 | 236/8465 | 4.04e-04 | 4.50e-03 | 3.05e-03 | 49 |
hsa040141 | Colorectum | CRC | Ras signaling pathway | 49/1091 | 236/8465 | 4.04e-04 | 4.50e-03 | 3.05e-03 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASAL2 | SNV | Missense_Mutation | rs750926173 | c.190N>A | p.Val64Ile | p.V64I | Q9UJF2 | protein_coding | tolerated_low_confidence(0.24) | benign(0.031) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RASAL2 | SNV | Missense_Mutation | c.277N>C | p.Lys93Gln | p.K93Q | Q9UJF2 | protein_coding | tolerated(0.06) | possibly_damaging(0.548) | TCGA-NH-A6GC-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD | |
RASAL2 | SNV | Missense_Mutation | c.2615N>A | p.Ile872Lys | p.I872K | Q9UJF2 | protein_coding | tolerated(0.92) | benign(0.006) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RASAL2 | SNV | Missense_Mutation | c.760G>C | p.Gly254Arg | p.G254R | Q9UJF2 | protein_coding | tolerated(0.1) | benign(0.118) | TCGA-EI-6509-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
RASAL2 | SNV | Missense_Mutation | novel | c.284N>A | p.Cys95Tyr | p.C95Y | Q9UJF2 | protein_coding | deleterious(0) | benign(0.264) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RASAL2 | SNV | Missense_Mutation | rs772116589 | c.1519C>T | p.Arg507Cys | p.R507C | Q9UJF2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RASAL2 | deletion | Frame_Shift_Del | rs775329137 | c.1159delN | p.Lys389ArgfsTer7 | p.K389Rfs*7 | Q9UJF2 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RASAL2 | deletion | Frame_Shift_Del | rs775329137 | c.1159delN | p.Lys389ArgfsTer7 | p.K389Rfs*7 | Q9UJF2 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
RASAL2 | insertion | In_Frame_Ins | novel | c.1011_1012insTTT | p.Cys337_Glu338insPhe | p.C337_E338insF | Q9UJF2 | protein_coding | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | ||
RASAL2 | insertion | Frame_Shift_Ins | novel | c.1012_1013insGTCTTGCTGGTTGTACGAGCAAAGAGGGTATCATC | p.Glu338GlyfsTer70 | p.E338Gfs*70 | Q9UJF2 | protein_coding | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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