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Gene: RANBP3 |
Gene summary for RANBP3 |
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Gene information | Species | Human | Gene symbol | RANBP3 | Gene ID | 8498 |
Gene name | RAN binding protein 3 | |
Gene Alias | RANBP3 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006611 | UniProtAcc | B7Z7F3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8498 | RANBP3 | LZE4T | Human | Esophagus | ESCC | 1.05e-11 | 2.36e-01 | 0.0811 |
8498 | RANBP3 | LZE7T | Human | Esophagus | ESCC | 9.20e-15 | 5.83e-01 | 0.0667 |
8498 | RANBP3 | LZE8T | Human | Esophagus | ESCC | 2.41e-12 | 2.64e-01 | 0.067 |
8498 | RANBP3 | LZE20T | Human | Esophagus | ESCC | 1.87e-02 | 4.45e-02 | 0.0662 |
8498 | RANBP3 | LZE21D1 | Human | Esophagus | HGIN | 1.45e-03 | 2.00e-01 | 0.0632 |
8498 | RANBP3 | LZE22T | Human | Esophagus | ESCC | 2.41e-05 | 2.17e-01 | 0.068 |
8498 | RANBP3 | LZE24T | Human | Esophagus | ESCC | 6.60e-16 | 3.64e-01 | 0.0596 |
8498 | RANBP3 | LZE21T | Human | Esophagus | ESCC | 5.54e-08 | 2.36e-01 | 0.0655 |
8498 | RANBP3 | LZE6T | Human | Esophagus | ESCC | 5.48e-05 | 2.03e-01 | 0.0845 |
8498 | RANBP3 | P1T-E | Human | Esophagus | ESCC | 1.10e-06 | 3.52e-01 | 0.0875 |
8498 | RANBP3 | P2T-E | Human | Esophagus | ESCC | 1.70e-14 | 2.80e-01 | 0.1177 |
8498 | RANBP3 | P4T-E | Human | Esophagus | ESCC | 3.97e-17 | 3.57e-01 | 0.1323 |
8498 | RANBP3 | P5T-E | Human | Esophagus | ESCC | 7.16e-16 | 2.71e-01 | 0.1327 |
8498 | RANBP3 | P8T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.27e-01 | 0.0889 |
8498 | RANBP3 | P9T-E | Human | Esophagus | ESCC | 5.53e-21 | 4.16e-01 | 0.1131 |
8498 | RANBP3 | P10T-E | Human | Esophagus | ESCC | 9.04e-21 | 4.36e-01 | 0.116 |
8498 | RANBP3 | P11T-E | Human | Esophagus | ESCC | 1.18e-18 | 4.63e-01 | 0.1426 |
8498 | RANBP3 | P12T-E | Human | Esophagus | ESCC | 2.71e-21 | 4.26e-01 | 0.1122 |
8498 | RANBP3 | P15T-E | Human | Esophagus | ESCC | 1.11e-12 | 2.88e-01 | 0.1149 |
8498 | RANBP3 | P16T-E | Human | Esophagus | ESCC | 5.07e-25 | 2.94e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000691319 | Esophagus | HGIN | nucleocytoplasmic transport | 83/2587 | 301/18723 | 2.14e-10 | 1.97e-08 | 83 |
GO:005116919 | Esophagus | HGIN | nuclear transport | 83/2587 | 301/18723 | 2.14e-10 | 1.97e-08 | 83 |
GO:005116819 | Esophagus | HGIN | nuclear export | 48/2587 | 154/18723 | 2.21e-08 | 1.34e-06 | 48 |
GO:000661110 | Esophagus | HGIN | protein export from nucleus | 22/2587 | 57/18723 | 2.96e-06 | 1.02e-04 | 22 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:000661117 | Esophagus | ESCC | protein export from nucleus | 48/8552 | 57/18723 | 1.92e-09 | 4.39e-08 | 48 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116817 | Oral cavity | OSCC | nuclear export | 112/7305 | 154/18723 | 1.70e-17 | 1.56e-15 | 112 |
GO:00066119 | Oral cavity | OSCC | protein export from nucleus | 42/7305 | 57/18723 | 1.10e-07 | 1.87e-06 | 42 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:0051168111 | Skin | cSCC | nuclear export | 91/4864 | 154/18723 | 3.33e-18 | 4.18e-16 | 91 |
GO:000661119 | Skin | cSCC | protein export from nucleus | 34/4864 | 57/18723 | 8.07e-08 | 1.96e-06 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516639 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa05166114 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa05166113 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RANBP3 | SNV | Missense_Mutation | rs766342300 | c.1541N>A | p.Arg514His | p.R514H | Q9H6Z4 | protein_coding | tolerated(0.23) | benign(0.034) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RANBP3 | SNV | Missense_Mutation | novel | c.194N>A | p.Pro65His | p.P65H | Q9H6Z4 | protein_coding | tolerated_low_confidence(0.73) | benign(0.241) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RANBP3 | SNV | Missense_Mutation | c.35N>C | p.Ile12Thr | p.I12T | Q9H6Z4 | protein_coding | deleterious_low_confidence(0) | benign(0.051) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RANBP3 | SNV | Missense_Mutation | c.521N>T | p.Pro174Leu | p.P174L | Q9H6Z4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RANBP3 | SNV | Missense_Mutation | novel | c.927N>A | p.Asn309Lys | p.N309K | Q9H6Z4 | protein_coding | tolerated(0.11) | benign(0.222) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RANBP3 | SNV | Missense_Mutation | rs750636234 | c.518N>A | p.Arg173His | p.R173H | Q9H6Z4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RANBP3 | insertion | Frame_Shift_Ins | rs767283381 | c.130_131insG | p.Glu44GlyfsTer3 | p.E44Gfs*3 | Q9H6Z4 | protein_coding | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | ||
RANBP3 | deletion | Frame_Shift_Del | rs865971344 | c.145delN | p.His49ThrfsTer15 | p.H49Tfs*15 | Q9H6Z4 | protein_coding | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RANBP3 | SNV | Missense_Mutation | novel | c.821N>T | p.Asn274Ile | p.N274I | Q9H6Z4 | protein_coding | deleterious(0) | benign(0.08) | TCGA-DD-AADG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
RANBP3 | SNV | Missense_Mutation | c.1369N>T | p.Thr457Ser | p.T457S | Q9H6Z4 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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