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Gene: QPCT |
Gene summary for QPCT |
Gene summary. |
Gene information | Species | Human | Gene symbol | QPCT | Gene ID | 25797 |
Gene name | glutaminyl-peptide cyclotransferase | |
Gene Alias | GCT | |
Cytomap | 2p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q16769 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25797 | QPCT | LZE7T | Human | Esophagus | ESCC | 4.66e-03 | 4.21e-01 | 0.0667 |
25797 | QPCT | P2T-E | Human | Esophagus | ESCC | 7.66e-13 | 4.26e-01 | 0.1177 |
25797 | QPCT | P8T-E | Human | Esophagus | ESCC | 6.11e-04 | 2.91e-02 | 0.0889 |
25797 | QPCT | P11T-E | Human | Esophagus | ESCC | 3.02e-07 | 3.32e-01 | 0.1426 |
25797 | QPCT | P16T-E | Human | Esophagus | ESCC | 3.43e-18 | 6.01e-01 | 0.1153 |
25797 | QPCT | P24T-E | Human | Esophagus | ESCC | 7.71e-07 | 2.09e-01 | 0.1287 |
25797 | QPCT | P26T-E | Human | Esophagus | ESCC | 2.01e-08 | 2.29e-01 | 0.1276 |
25797 | QPCT | P37T-E | Human | Esophagus | ESCC | 1.33e-02 | 9.91e-02 | 0.1371 |
25797 | QPCT | P44T-E | Human | Esophagus | ESCC | 7.89e-03 | 2.11e-01 | 0.1096 |
25797 | QPCT | P56T-E | Human | Esophagus | ESCC | 5.12e-06 | 1.42e+00 | 0.1613 |
25797 | QPCT | P61T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.41e-01 | 0.099 |
25797 | QPCT | P74T-E | Human | Esophagus | ESCC | 1.62e-10 | 4.30e-01 | 0.1479 |
25797 | QPCT | P76T-E | Human | Esophagus | ESCC | 2.52e-16 | 4.46e-01 | 0.1207 |
25797 | QPCT | P79T-E | Human | Esophagus | ESCC | 3.53e-04 | 3.63e-02 | 0.1154 |
25797 | QPCT | P82T-E | Human | Esophagus | ESCC | 5.38e-04 | 6.35e-01 | 0.1072 |
25797 | QPCT | P89T-E | Human | Esophagus | ESCC | 2.33e-04 | 8.04e-01 | 0.1752 |
25797 | QPCT | P126T-E | Human | Esophagus | ESCC | 1.87e-02 | 3.26e-01 | 0.1125 |
25797 | QPCT | P130T-E | Human | Esophagus | ESCC | 1.49e-40 | 1.15e+00 | 0.1676 |
25797 | QPCT | male-WTA | Human | Thyroid | PTC | 1.63e-35 | 4.36e-01 | 0.1037 |
25797 | QPCT | PTC01 | Human | Thyroid | PTC | 7.38e-47 | 1.11e+00 | 0.1899 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
QPCT | SNV | Missense_Mutation | c.895N>A | p.Tyr299Asn | p.Y299N | Q16769 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
QPCT | SNV | Missense_Mutation | c.260C>T | p.Ala87Val | p.A87V | Q16769 | protein_coding | tolerated(1) | benign(0.003) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
QPCT | SNV | Missense_Mutation | rs151306583 | c.548N>G | p.Thr183Ser | p.T183S | Q16769 | protein_coding | tolerated(0.66) | benign(0.058) | TCGA-93-7348-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
QPCT | SNV | Missense_Mutation | novel | c.599N>T | p.Gly200Val | p.G200V | Q16769 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-8624-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
QPCT | SNV | Missense_Mutation | novel | c.205N>A | p.Asp69Asn | p.D69N | Q16769 | protein_coding | tolerated(0.27) | probably_damaging(0.977) | TCGA-63-7022-01 | Lung | lung squamous cell carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
QPCT | SNV | Missense_Mutation | novel | c.293N>A | p.Leu98His | p.L98H | Q16769 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-77-A5G7-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
QPCT | SNV | Missense_Mutation | rs753696536 | c.484N>A | p.Val162Met | p.V162M | Q16769 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-6491-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
QPCT | SNV | Missense_Mutation | novel | c.1018N>A | p.Asp340Asn | p.D340N | Q16769 | protein_coding | tolerated(0.26) | possibly_damaging(0.838) | TCGA-CV-7247-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
QPCT | SNV | Missense_Mutation | c.197N>T | p.Trp66Leu | p.W66L | Q16769 | protein_coding | deleterious(0.01) | benign(0.173) | TCGA-CD-5813-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
QPCT | SNV | Missense_Mutation | c.569N>T | p.Asp190Val | p.D190V | Q16769 | protein_coding | deleterious(0.04) | possibly_damaging(0.75) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
25797 | QPCT | ENZYME, PROTEASE, DRUGGABLE GENOME | PQ-912 | 24403873 | ||
25797 | QPCT | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | 252166568 |
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