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Gene: PYGO2 |
Gene summary for PYGO2 |
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Gene information | Species | Human | Gene symbol | PYGO2 | Gene ID | 90780 |
Gene name | pygopus family PHD finger 2 | |
Gene Alias | 1190004M21Rik | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q5T170 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90780 | PYGO2 | LZE4T | Human | Esophagus | ESCC | 4.36e-07 | 1.38e-01 | 0.0811 |
90780 | PYGO2 | LZE7T | Human | Esophagus | ESCC | 2.67e-13 | 3.16e-01 | 0.0667 |
90780 | PYGO2 | LZE20T | Human | Esophagus | ESCC | 8.72e-07 | 1.19e-01 | 0.0662 |
90780 | PYGO2 | LZE22T | Human | Esophagus | ESCC | 3.10e-05 | 4.06e-01 | 0.068 |
90780 | PYGO2 | LZE24T | Human | Esophagus | ESCC | 1.49e-13 | 3.44e-01 | 0.0596 |
90780 | PYGO2 | LZE21T | Human | Esophagus | ESCC | 1.50e-02 | 1.96e-01 | 0.0655 |
90780 | PYGO2 | P1T-E | Human | Esophagus | ESCC | 6.94e-05 | 2.06e-01 | 0.0875 |
90780 | PYGO2 | P2T-E | Human | Esophagus | ESCC | 9.74e-21 | 3.51e-01 | 0.1177 |
90780 | PYGO2 | P4T-E | Human | Esophagus | ESCC | 3.92e-14 | 2.93e-01 | 0.1323 |
90780 | PYGO2 | P5T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.72e-01 | 0.1327 |
90780 | PYGO2 | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 1.76e-01 | 0.0889 |
90780 | PYGO2 | P9T-E | Human | Esophagus | ESCC | 7.16e-13 | 1.99e-01 | 0.1131 |
90780 | PYGO2 | P10T-E | Human | Esophagus | ESCC | 9.67e-18 | 2.84e-01 | 0.116 |
90780 | PYGO2 | P11T-E | Human | Esophagus | ESCC | 2.47e-14 | 4.06e-01 | 0.1426 |
90780 | PYGO2 | P12T-E | Human | Esophagus | ESCC | 1.11e-16 | 2.33e-01 | 0.1122 |
90780 | PYGO2 | P15T-E | Human | Esophagus | ESCC | 9.76e-24 | 4.41e-01 | 0.1149 |
90780 | PYGO2 | P16T-E | Human | Esophagus | ESCC | 4.24e-18 | 3.01e-01 | 0.1153 |
90780 | PYGO2 | P17T-E | Human | Esophagus | ESCC | 7.84e-11 | 2.80e-01 | 0.1278 |
90780 | PYGO2 | P19T-E | Human | Esophagus | ESCC | 1.33e-03 | 4.00e-01 | 0.1662 |
90780 | PYGO2 | P20T-E | Human | Esophagus | ESCC | 7.37e-15 | 2.56e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:0051099111 | Esophagus | ESCC | positive regulation of binding | 122/8552 | 173/18723 | 2.79e-11 | 9.45e-10 | 122 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PYGO2 | SNV | Missense_Mutation | novel | c.1183N>A | p.Glu395Lys | p.E395K | Q9BRQ0 | protein_coding | tolerated(0.08) | benign(0.055) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PYGO2 | SNV | Missense_Mutation | novel | c.949G>T | p.Gly317Cys | p.G317C | Q9BRQ0 | protein_coding | tolerated(0.13) | benign(0.161) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PYGO2 | SNV | Missense_Mutation | novel | c.815N>T | p.Pro272Leu | p.P272L | Q9BRQ0 | protein_coding | tolerated(0.28) | benign(0.431) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PYGO2 | SNV | Missense_Mutation | c.1126N>A | p.Val376Ile | p.V376I | Q9BRQ0 | protein_coding | tolerated(0.09) | possibly_damaging(0.712) | TCGA-B7-A5TJ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PYGO2 | SNV | Missense_Mutation | c.530N>A | p.Pro177His | p.P177H | Q9BRQ0 | protein_coding | tolerated(0.51) | probably_damaging(0.996) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PYGO2 | SNV | Missense_Mutation | c.971N>T | p.Pro324Leu | p.P324L | Q9BRQ0 | protein_coding | deleterious(0) | benign(0.081) | TCGA-HU-A4G3-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | SD | |
PYGO2 | insertion | Frame_Shift_Ins | rs748504064 | c.448_449insC | p.Gln150ProfsTer27 | p.Q150Pfs*27 | Q9BRQ0 | protein_coding | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
PYGO2 | insertion | Frame_Shift_Ins | rs748504064 | c.448dupC | p.Gln150ProfsTer27 | p.Q150Pfs*27 | Q9BRQ0 | protein_coding | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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