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Gene: PXK |
Gene summary for PXK |
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Gene information | Species | Human | Gene symbol | PXK | Gene ID | 54899 |
Gene name | PX domain containing serine/threonine kinase like | |
Gene Alias | MONAKA | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A0C4DG95 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54899 | PXK | HCC1_Meng | Human | Liver | HCC | 2.34e-11 | -1.36e-03 | 0.0246 |
54899 | PXK | S014 | Human | Liver | HCC | 1.79e-25 | 9.89e-01 | 0.2254 |
54899 | PXK | S015 | Human | Liver | HCC | 9.10e-25 | 1.38e+00 | 0.2375 |
54899 | PXK | S016 | Human | Liver | HCC | 3.05e-38 | 1.16e+00 | 0.2243 |
54899 | PXK | S027 | Human | Liver | HCC | 7.13e-08 | 5.68e-01 | 0.2446 |
54899 | PXK | S028 | Human | Liver | HCC | 6.26e-16 | 6.05e-01 | 0.2503 |
54899 | PXK | S029 | Human | Liver | HCC | 2.04e-14 | 7.67e-01 | 0.2581 |
54899 | PXK | male-WTA | Human | Thyroid | PTC | 7.43e-26 | 9.91e-02 | 0.1037 |
54899 | PXK | PTC01 | Human | Thyroid | PTC | 8.46e-14 | -2.07e-02 | 0.1899 |
54899 | PXK | PTC04 | Human | Thyroid | PTC | 2.21e-11 | 3.36e-02 | 0.1927 |
54899 | PXK | PTC05 | Human | Thyroid | PTC | 2.46e-18 | 7.38e-01 | 0.2065 |
54899 | PXK | PTC06 | Human | Thyroid | PTC | 1.09e-22 | 3.75e-01 | 0.2057 |
54899 | PXK | PTC07 | Human | Thyroid | PTC | 3.24e-18 | 3.11e-01 | 0.2044 |
54899 | PXK | ATC12 | Human | Thyroid | ATC | 2.36e-10 | -1.12e-01 | 0.34 |
54899 | PXK | ATC13 | Human | Thyroid | ATC | 7.09e-17 | 1.97e-01 | 0.34 |
54899 | PXK | ATC2 | Human | Thyroid | ATC | 3.84e-02 | 5.93e-01 | 0.34 |
54899 | PXK | ATC3 | Human | Thyroid | ATC | 2.07e-02 | -7.30e-02 | 0.338 |
54899 | PXK | ATC4 | Human | Thyroid | ATC | 1.10e-08 | -7.85e-02 | 0.34 |
54899 | PXK | ATC5 | Human | Thyroid | ATC | 1.59e-19 | 2.48e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005134622 | Liver | HCC | negative regulation of hydrolase activity | 195/7958 | 379/18723 | 2.44e-04 | 1.82e-03 | 195 |
GO:004346211 | Liver | HCC | regulation of ATPase activity | 29/7958 | 46/18723 | 3.95e-03 | 1.74e-02 | 29 |
GO:0051346112 | Thyroid | PTC | negative regulation of hydrolase activity | 146/5968 | 379/18723 | 3.33e-03 | 1.62e-02 | 146 |
GO:00510518 | Thyroid | PTC | negative regulation of transport | 176/5968 | 470/18723 | 5.44e-03 | 2.49e-02 | 176 |
GO:00434629 | Thyroid | PTC | regulation of ATPase activity | 23/5968 | 46/18723 | 7.89e-03 | 3.33e-02 | 23 |
GO:005134629 | Thyroid | ATC | negative regulation of hydrolase activity | 155/6293 | 379/18723 | 1.64e-03 | 8.23e-03 | 155 |
GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PXK | SNV | Missense_Mutation | novel | c.492N>A | p.Phe164Leu | p.F164L | Q7Z7A4 | protein_coding | tolerated(0.05) | possibly_damaging(0.651) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
PXK | SNV | Missense_Mutation | rs777405751 | c.1058N>T | p.Ser353Leu | p.S353L | Q7Z7A4 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
PXK | SNV | Missense_Mutation | novel | c.239N>G | p.Leu80Trp | p.L80W | Q7Z7A4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PXK | SNV | Missense_Mutation | novel | c.892G>A | p.Gly298Arg | p.G298R | Q7Z7A4 | protein_coding | tolerated(0.07) | possibly_damaging(0.873) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PXK | SNV | Missense_Mutation | novel | c.1004T>C | p.Val335Ala | p.V335A | Q7Z7A4 | protein_coding | deleterious(0.02) | possibly_damaging(0.625) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PXK | deletion | Frame_Shift_Del | rs766364681 | c.1368delN | p.Arg459GlufsTer4 | p.R459Efs*4 | Q7Z7A4 | protein_coding | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PXK | insertion | Frame_Shift_Ins | novel | c.1539_1540insT | p.Leu514PhefsTer58 | p.L514Ffs*58 | Q7Z7A4 | protein_coding | TCGA-AP-A0LH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | PD | ||
PXK | insertion | Frame_Shift_Ins | rs751548577 | c.1375dupA | p.Arg459LysfsTer15 | p.R459Kfs*15 | Q7Z7A4 | protein_coding | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
PXK | deletion | Frame_Shift_Del | rs766364681 | c.1368delN | p.Arg459GlufsTer4 | p.R459Efs*4 | Q7Z7A4 | protein_coding | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PXK | deletion | Frame_Shift_Del | rs766364681 | c.1368delN | p.Arg459GlufsTer4 | p.R459Efs*4 | Q7Z7A4 | protein_coding | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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