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Gene: PTGR1 |
Gene summary for PTGR1 |
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Gene information | Species | Human | Gene symbol | PTGR1 | Gene ID | 22949 |
Gene name | prostaglandin reductase 1 | |
Gene Alias | DIG-1 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q14914 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22949 | PTGR1 | AEH-subject1 | Human | Endometrium | AEH | 1.49e-04 | -1.20e-01 | -0.3059 |
22949 | PTGR1 | AEH-subject2 | Human | Endometrium | AEH | 1.47e-07 | 8.62e-02 | -0.2525 |
22949 | PTGR1 | AEH-subject3 | Human | Endometrium | AEH | 4.65e-14 | 2.82e-01 | -0.2576 |
22949 | PTGR1 | AEH-subject4 | Human | Endometrium | AEH | 1.67e-04 | 1.51e-02 | -0.2657 |
22949 | PTGR1 | EEC-subject1 | Human | Endometrium | EEC | 1.38e-07 | -7.63e-02 | -0.2682 |
22949 | PTGR1 | EEC-subject2 | Human | Endometrium | EEC | 5.65e-05 | -1.09e-01 | -0.2607 |
22949 | PTGR1 | EEC-subject3 | Human | Endometrium | EEC | 1.82e-29 | -2.58e-01 | -0.2525 |
22949 | PTGR1 | EEC-subject4 | Human | Endometrium | EEC | 3.28e-05 | -6.54e-02 | -0.2571 |
22949 | PTGR1 | EEC-subject5 | Human | Endometrium | EEC | 6.45e-07 | -1.31e-02 | -0.249 |
22949 | PTGR1 | GSM5276934 | Human | Endometrium | EEC | 1.51e-09 | -2.64e-01 | -0.0913 |
22949 | PTGR1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.19e-21 | -2.30e-01 | -0.1869 |
22949 | PTGR1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 5.65e-18 | -1.45e-01 | -0.1875 |
22949 | PTGR1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.91e-25 | -2.16e-01 | -0.1883 |
22949 | PTGR1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.85e-33 | -3.90e-01 | -0.1934 |
22949 | PTGR1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 9.28e-42 | -1.29e-01 | -0.1917 |
22949 | PTGR1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.41e-34 | -4.08e-02 | -0.1916 |
22949 | PTGR1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 6.71e-06 | 6.78e-02 | -0.1269 |
22949 | PTGR1 | LZE2T | Human | Esophagus | ESCC | 1.24e-11 | 2.40e+00 | 0.082 |
22949 | PTGR1 | LZE4T | Human | Esophagus | ESCC | 1.01e-54 | 2.91e+00 | 0.0811 |
22949 | PTGR1 | LZE7T | Human | Esophagus | ESCC | 6.59e-16 | 2.05e+00 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:000669211 | Esophagus | ESCC | prostanoid metabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
GO:000669311 | Esophagus | ESCC | prostaglandin metabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
GO:00066316 | Liver | NAFLD | fatty acid metabolic process | 92/1882 | 390/18723 | 3.38e-15 | 3.29e-12 | 92 |
GO:00335596 | Liver | NAFLD | unsaturated fatty acid metabolic process | 24/1882 | 116/18723 | 4.64e-04 | 6.74e-03 | 24 |
GO:00066906 | Liver | NAFLD | icosanoid metabolic process | 22/1882 | 123/18723 | 5.33e-03 | 4.11e-02 | 22 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:00066926 | Liver | Cirrhotic | prostanoid metabolic process | 22/4634 | 49/18723 | 1.64e-03 | 1.05e-02 | 22 |
GO:00066936 | Liver | Cirrhotic | prostaglandin metabolic process | 22/4634 | 49/18723 | 1.64e-03 | 1.05e-02 | 22 |
GO:003355911 | Liver | Cirrhotic | unsaturated fatty acid metabolic process | 43/4634 | 116/18723 | 2.09e-03 | 1.29e-02 | 43 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:1901568 | Liver | HCC | fatty acid derivative metabolic process | 43/7958 | 74/18723 | 4.85e-03 | 2.04e-02 | 43 |
GO:00066317 | Oral cavity | OSCC | fatty acid metabolic process | 186/7305 | 390/18723 | 2.65e-04 | 1.69e-03 | 186 |
GO:00066928 | Oral cavity | OSCC | prostanoid metabolic process | 29/7305 | 49/18723 | 3.33e-03 | 1.42e-02 | 29 |
GO:00066938 | Oral cavity | OSCC | prostaglandin metabolic process | 29/7305 | 49/18723 | 3.33e-03 | 1.42e-02 | 29 |
GO:00066315 | Stomach | GC | fatty acid metabolic process | 55/1159 | 390/18723 | 8.63e-09 | 8.38e-07 | 55 |
GO:0033559 | Stomach | GC | unsaturated fatty acid metabolic process | 24/1159 | 116/18723 | 1.43e-07 | 8.35e-06 | 24 |
GO:0006690 | Stomach | GC | icosanoid metabolic process | 24/1159 | 123/18723 | 4.49e-07 | 2.32e-05 | 24 |
GO:0006692 | Stomach | GC | prostanoid metabolic process | 13/1159 | 49/18723 | 5.93e-06 | 2.30e-04 | 13 |
GO:0006693 | Stomach | GC | prostaglandin metabolic process | 13/1159 | 49/18723 | 5.93e-06 | 2.30e-04 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGR1 | SNV | Missense_Mutation | rs376212074 | c.796N>T | p.Arg266Cys | p.R266C | Q14914 | protein_coding | deleterious(0.05) | benign(0.019) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
PTGR1 | SNV | Missense_Mutation | novel | c.19N>C | p.Trp7Arg | p.W7R | Q14914 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
PTGR1 | deletion | Frame_Shift_Del | novel | c.101delA | p.Asn34MetfsTer17 | p.N34Mfs*17 | Q14914 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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