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Gene: PTGDR |
Gene summary for PTGDR |
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Gene information | Species | Human | Gene symbol | PTGDR | Gene ID | 5729 |
Gene name | prostaglandin D2 receptor | |
Gene Alias | AS1 | |
Cytomap | 14q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q13258 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5729 | PTGDR | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.06e-11 | -5.44e-01 | 0.0155 |
5729 | PTGDR | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.15e-07 | -6.51e-01 | -0.1808 |
5729 | PTGDR | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.41e-06 | -6.57e-01 | -0.0811 |
5729 | PTGDR | HTA11_78_2000001011 | Human | Colorectum | AD | 8.31e-08 | -6.20e-01 | -0.1088 |
5729 | PTGDR | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.62e-07 | -6.85e-01 | -0.1207 |
5729 | PTGDR | HTA11_83_2000001011 | Human | Colorectum | SER | 1.05e-02 | -5.64e-01 | -0.1526 |
5729 | PTGDR | HTA11_696_2000001011 | Human | Colorectum | AD | 1.14e-24 | -6.81e-01 | -0.1464 |
5729 | PTGDR | HTA11_866_2000001011 | Human | Colorectum | AD | 7.12e-10 | -4.87e-01 | -0.1001 |
5729 | PTGDR | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.19e-19 | -7.60e-01 | -0.059 |
5729 | PTGDR | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.64e-04 | -7.70e-01 | -0.2061 |
5729 | PTGDR | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-04 | -5.07e-01 | 0.096 |
5729 | PTGDR | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.05e-12 | -5.34e-01 | 0.0674 |
5729 | PTGDR | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.41e-07 | -2.86e-01 | 0.294 |
5729 | PTGDR | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.30e-41 | -7.95e-01 | 0.3859 |
5729 | PTGDR | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.79e-11 | -7.95e-01 | 0.2585 |
5729 | PTGDR | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.12e-43 | -7.95e-01 | 0.3005 |
5729 | PTGDR | F007 | Human | Colorectum | FAP | 9.11e-09 | -6.22e-01 | 0.1176 |
5729 | PTGDR | A001-C-207 | Human | Colorectum | FAP | 1.12e-09 | -5.40e-01 | 0.1278 |
5729 | PTGDR | A015-C-203 | Human | Colorectum | FAP | 3.54e-24 | -5.09e-01 | -0.1294 |
5729 | PTGDR | A015-C-204 | Human | Colorectum | FAP | 1.24e-04 | -3.99e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:00516564 | Colorectum | CRC | establishment of organelle localization | 76/2078 | 390/18723 | 6.53e-07 | 4.50e-05 | 76 |
GO:00068872 | Colorectum | CRC | exocytosis | 55/2078 | 352/18723 | 5.62e-03 | 4.24e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGDR | SNV | Missense_Mutation | c.494N>T | p.Ala165Val | p.A165V | Q13258 | protein_coding | tolerated(0.12) | benign(0.15) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTGDR | SNV | Missense_Mutation | rs749447321 | c.167C>T | p.Pro56Leu | p.P56L | Q13258 | protein_coding | tolerated(0.11) | benign(0.176) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTGDR | SNV | Missense_Mutation | novel | c.691N>T | p.Arg231Trp | p.R231W | Q13258 | protein_coding | deleterious(0) | possibly_damaging(0.763) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTGDR | SNV | Missense_Mutation | novel | c.546N>T | p.Trp182Cys | p.W182C | Q13258 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGDR | SNV | Missense_Mutation | novel | c.955G>T | p.Asp319Tyr | p.D319Y | Q13258 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGDR | SNV | Missense_Mutation | novel | c.662C>T | p.Ala221Val | p.A221V | Q13258 | protein_coding | tolerated(1) | benign(0.02) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTGDR | SNV | Missense_Mutation | c.330N>A | p.Phe110Leu | p.F110L | Q13258 | protein_coding | deleterious(0.03) | probably_damaging(0.968) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
PTGDR | SNV | Missense_Mutation | novel | c.865N>T | p.Ala289Ser | p.A289S | Q13258 | protein_coding | tolerated(0.34) | benign(0.141) | TCGA-2Y-A9H0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
PTGDR | SNV | Missense_Mutation | c.873N>T | p.Lys291Asn | p.K291N | Q13258 | protein_coding | tolerated(0.39) | benign(0.026) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PTGDR | SNV | Missense_Mutation | c.737C>A | p.Pro246Gln | p.P246Q | Q13258 | protein_coding | tolerated(0.05) | possibly_damaging(0.897) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | PGF2alpha | |||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135649910 | ||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | TS-022 | |||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650477 | ||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | AMG 853 | |||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | MK-1029 | MK-1029 | ||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651542 | ||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | ONO-4053 | |||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | S-555739 | ASAPIPRANT | ||
5729 | PTGDR | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | AM-461 | AM-461 |
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